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Occurrence of comorbidity following osteoarthritis diagnosis : a cohort study in the Netherlands

Objective: To determine the risk of comorbidity following diagnosis of knee or hip osteoarthritis (OA). Design: A cohort study was conducted using the Integrated Primary Care Information database, containing electronic health records of 2.5 million patients from the Netherlands. Adults at risk for OA were included. Diagnosis of knee or hip OA (=exposure) and 58 long-term comorbidities (=outcome) w

Placement of Fast-Charging Infrastructure for Long-Haul Road Freight Based on Spatio-Temporal Evaluation of En-Route Energy Needs

The rapid progression of the electrification of road transport in many countries urges the need to make informed decisions on the location and size of the required charging infrastructure. This paper’s main contribution is a novel method to position fast-charging stations based on the transportation energy demand and to evaluate the performance of such charging infrastructure. Depending on their r

Mvschema2016-07-31 3

VÄLKOMMEN TILL Preliminärt Schema 2016-07-31 Välkommen till Miljövetenskap grundkurs MVEA01 - HT 2016 (29/8-28/10) Länk till webbschema Kursansvarig: Katarina Hedlund 046/2223798, e-mail: Katarina.Hedlund@biol.lu.se Kurshemsida: http://www.cec.lu.se/sv/utbildning/miljovetenskap-grund-och- avancerad-utbildning/kurser/miljovetenskap-grundkurs-15hp och intern kurskommunikation - http://luvit.ced.lu.s

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mvschema2016-07-31_3.pdf - 2026-06-02

Prevention and Management of Bleeding Episodes in Children with Hemophilia

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions.

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals. EndoS hydrolysis of the IgG glyca

Induction of platelet thrombi by bacteria and antibodies.

We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai

Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Countercurrent distribution of lymphocytes from human peripheral blood in an aqueous two-phase system. : II. Separation into subsets of lymphocytes with distinctive functions

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

231221 Avgifter 2024 SLUTLIG

Brevmall Avgifter fr.o.m. 1 januari 2024 Personer födda 1937 eller tidigare Personer födda 1938 – 1954 Personer födda 1955 – 1957 1) 2) Personer födda 1958 – 1965 2) Personer födda 1966 – 1987 2) Personer födda 1988-- Arbetsgivaravgift 31,42 % 31,42 % 31,42 % (240101 slopas nedsättningen av arb giv avg för de som vid årets ingång fyllt 15 men inte 18 år, vilket innebär att arb giv avg för unga är

https://www.hr-webben.lu.se/sites/hr-webben.lu.se/files/2025-12/231221%20Avgifter%202024%20SLUTLIG.pdf - 2026-06-02

Lakatos's challenge? : Auxiliary hypotheses and non-monotonous inference

Gerhard Schurz [2001, Journal for General Philosophy of Science, 32, 65-107] has proposed to reconstruct auxiliary hypothesis addition, e.g., postulation of Neptune to immunize Newtonian mechanics, with concepts from non-monotonous inference to avoid the retention of false predictions that are among the consequence-set of the deductive model. However, the non-monotonous reconstruction retains the

Solitary living in Alzheimer's disease over 3 years: association between cognitive and functional impairment and community-based services.

Introduction: Many individuals with Alzheimer’s disease (AD) live alone, and this figure is expected to increase. This study aimed to describe the cognitive and functional abilities of solitary-living AD patients, and the potential predictors of their usage of community-based services. Methods: This 3-year, prospective, multicenter study included 1,021 participants with mild-to-moderate AD (Mini-M

“Heading for the Abyss” Interstate friendship, anxiety and state biographical narrative change in Austria

The purpose of this thesis is to examine how state biographical narratives can change and how this process might affect a state’s ontological security. Moreover, it looks at whether interstate friendship could alleviate any feelings of anxiety caused by such changes. Using the case of Austria after World War II, the analysis focuses on political elites’ articulations of Austrian state identity alo

Osynlighetens mellanförskap: autistiska kvinnors upplevelser och tankar om normalitet och moderskap.

This thesis is about autistic women. It is about how we, as a society, construct and perceive normality and motherhood as a normative ideal for women. It is also about a dis/ability that often goes unnoticed since autism is not defined by any visible markers. Rather, autism is categorized by behaviour considered atypical through the medical gaze. How to make visible the invisible, the in-between