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Basic fibroblast growth factor (FGF-2) is involved in the development and maintenance of the nervous system. Exogenous administration of FGF-2 increased dopaminergic (DA) graft survival in different animal models of Parkinson's disease. To study the physiological function of the endogenous FGF-2 system, we analyzed the nigrostriatal system of mice lacking FGF-2, mice overexpressing FGF-2, and FGF-
We present an approach proving the integrability of the Camassa-Holm equation for initial data of small amplitude.
Complement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this study we demonstrate that N. g
To reach its large computing needs, the ALICE experiment at CERN has developed its own middleware called AliEn, centralised and relying on pilot jobs. One of its strength is the automatic installation of the required packages. The Nordic countries have offered a distributed Tier-1 centre for the CERN experiments, where the job management should be done with the NorduGrid middleware ARC. We have de
This paper presents a new and practical simulation interface to design and analyze lower-limb prosthetic devices. The proposed tool simulates the gait of a lower limb amputee using a desired prosthetic device. It allows the analysis of simple passive devices or the testing of control algorithms for active prostheses. The results presented in this paper correspond to the use of this tool to test a
The monotone rearrrangement algorithm was introduced by Hardy, Littlewood and Po ́lya as a sorting device for functions. As- suming that x is a monotone function and that an estimate xn of x is given, consider the monotone rearrangement xˆn of xn. This new estimator is shown to be uniformly consistent. Under suitable as- sumptions, pointwise limit distribution results for xˆn are obtained. The fra
With today’s rapid changes in socio-economy and technology, knowledge and learning are critical issues for private and civil service organizations. The needs for competence development range from short informal courses (without ECTS credits) to formal courses at university level (with ECTS credits). This article describes objectives and results of a Leonardo project, eGIS+ that developed and imple
It is often suggested that the emittance coupling of a storage ring should be adjusted to the so-called diffraction limit corresponding to the shortest wavelength of interest. For 1 Å radiation this leads to a typical requirement of 8 pm rad vertical emittance. In ultralow-emittance storage rings like the MAX IV 3 GeV storage ring this corresponds to a comparably large setting of the emittance cou
Current cardiovascular risk scores do not include obesity or fat distribution as independent factors, and may underestimate risk in obese individuals. Assessment of early vascular ageing (EVA) biomarkers including arterial stiffness, central blood pressure, carotid intima-media thickness and flow-mediated vasodilation may help to refine risk assessment in obese individuals in whom traditional card
Microdialysis was used for sampling enzyme hydrolysis products of starch hydrolysed with beta -amylase, pullulanase, and/or isoamylase, to obtain information about the molecular structure of starch. Starches from waxy, normal, and high amylose maize, and from normal and genetically modified potato (amylose deficient) were used, and also commercial potato amyloses. The hydrolysis products were anal
The lymphatic system, composed of lymphatic vessels, lymph, lymph nodes, and lymphocytes, is a distinctive vasculature (discontinuous basement membrane, open endothelial junctions, anchoring filaments, valves, and intrinsic contractility), different yet similar to the blood vasculature; an integral component of the plasma-tissue fluid-lymph circulation (the "blood-lymph loop"); and the center of t
The CCSD(T) method has been used to compute a highly accurate quartic force field and fundamental frequencies for all 16O and 18O isotopomers of the ozonide anion. The CCSD and CASPT2 methods have also been used to verify the reliability of the CCSD(T) fundamental frequencies. The computed fundamental frequencies are in agreement with gas-phase experiments, but disagree with matrix isolation exper
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation(1-4), the age of an association between these bacteria with humans remains highly controversial(5,6). Here we show, using sequences from a large data set of bacterial strains that, as in humans, gen
The number and diversity of chemicals produced and used in society today are growing in conjunction with the both evident and uncertain environmental impacts associated with the life cycles of these chemicals. Chemical management services (CMS) is a business strategy based on a strategic, long-term contract, according to which the supplier of chemical management services accepts the responsibility
Disturbances in swallowing are common in neurologic disease but difficult to evaluate in the clinical setting. Fundamental variables such as bolus volume, swallow capacity (volume ingested over time), and the relation between ingestion and time for important events in oral and pharyngeal swallowing have not been sufficiently studied. We therefore employed a composite method for monitoring oral and
Appearance of dyskinesia is a common problem of long-term l-DOPA treatment in Parkinson's disease patients and represents a major limitation for the pharmacological management of the motor symptoms in advanced disease stages. We have recently demonstrated that dopamine released from serotonin neurons is responsible for l-DOPA-induced dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, raising
The Ebf (O/E) family of helix-loop-helix transcription factors plays a significant role in B lymphocyte and neuronal development. The three primary members of this family, Ebf1, 2, and 3, are all expressed in adipocytes, and Ebf1 promotes adipogenesis when overexpressed in NIH 3T3 fibroblasts. Here we report that these three proteins have adipogenic potential in multiple cellular models and that p
