Filtyp
Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical PARP inhibitors and commonly used research tools for their inhibition of multiple PARP enzymes. We also determined crystal structures of these compounds bound to PARP1 or PARP2. Veliparib and niraparib are selective i
Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a
Background Starting in the 1960s, a broad-based patients’ rights movement began to question doctors’ paternalism and to demand disclosure of medical information, informed consent, and active participation by the individual in personal health care. According to scholars, these changes contributed to downplay the biomedical approach in favor of a more patient-oriented perspective. The Swedish non-p
Popular Abstract in Swedish Luftföroreningar har i många studier visat sig skada vår hälsa. Även om risken för den enskilda individen kan vara relativt liten så kan omfattningen av hälsoeffekterna bli stora eftersom det är så många som exponeras. Tidigare har man huvudsakligen sett effekter på andningsorganen men under de senare åren har man även börjat se effekter som sträcker sig bortom våra andWe had in the present thesis the unique possibility to use, in a socio-economically relatively homogenous population, high quality registry information on a population-based birth cohort (84 039 births during the period 1999-2005) in Scania (Skåne), the most Southern county of Sweden. The aim of the thesis was to investigate whether exposure to air pollution, in an area of low-levels exposures, du
Popular Abstract in Swedish I avhandlingen presenteras nya teoretiska och experimentella metoder för att analysera spridning av elektromagnetiska vågor, framförallt med fokus på antenner och trådlös kommunikation. Oavsett det handlar om radio- och TV-sändningar, mobiltelefoni, trådlösa datornätverk, eller radar, så är antenner oumbärliga; de är nämligen länken mellan de elektromagnetiska vågorna oSum rules and physical limitations within electromagnetic theory and antenna theory have received significant attention in the last few years. However, the derivations are often relying on application specific and sometimes unsupported assumptions, and therefore a mathematically rigorous and generally applicable approach seems timely. Such an approach is presented in this thesis, along with exampl
The aim of this study was to determine effects on methane potential and overall sludge quality from two different sludge pre-treatment technologies (ozonation high/low dosage and thermal treatment 55/70 degrees C). In general both treatments produced increased methane potential. Thermal treatment resulted in higher chemical oxygen demand (COD)-solubilisation, while the highest volatile fatty acids
To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease.
To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 mutation carriers.
Drinking water disinfection byproducts have been associated with an increased risk for congenital defects including cardiac defects. Using Swedish health registers linked to information on municipal drinking water composition, individual data on drinking water characteristics were obtained for 58,669 women. Among the infants born, 753 had a cardiac defect. The risk for a cardiac defect was determi
The expected annual cost (in the year 2000 prices) for a 30-year-old patient with average individual and treatment characteristics for on-demand EUR 51 832 (95% CI: 44 324-59 341) and for prophylaxis EUR 146 118 (95% CI: 129 965-162 271), was obtained from panel-data analysis of an 11-year retrospective panel of 156 patients with severe haemophilia in Norway and Sweden. Costs included haemophilia-
This review is based on recent molecular studies of Dactylorhiza (Orchidaceae). Most of the studies have focused on the allotetraploid members of the genus in general and on D. majalis ssp. lapponica in particular. It was concluded that most of the allotetraploid taxa have derived from hybridizations between the parental lineages D. maculata s.l. and D. incarnata s.l., with D. maculata s.l. servin
Popular Abstract in Swedish Betændelses reaktionen er kroppens svar på en skade eller en infektion. Betændelses reaktionen gør at immunforsvarets celler kaldes til det skadede område (kan ses som den røde varme hævelse omkring et sår) og at eventuelle sygdomsfremkaldende emner identificeres og bekæmpes. På lidt længere sigt, fjernes ødelagt væv og helingen af såret påbegyndes. Når det skadede områThe pro-inflammatory mediators leukotrienes have shown to be important players in the pathogenesis of diseases like asthma and inflammatory bowel disease (IBD). Patients suffering from IBD have been found to have an increased risk of developing colon cancer. Since leukotrienes have been shown in increased concentrations in stools of IBD patients we hypothesise that LTD4 can play a role in the deve
Popular Abstract in Swedish Lysande plast, finns det? Tanken är att att tunn plast-film skall kunna användas som ihoprullbara tunna TV- och datorskärmar, som lysdioder, som mottagare i solceller och som transistorer. Till vardags är förmodligen den vanligaste uppfattningen att plast är ett isolerande material som inte leder ström och som därför heller inte lyser. Faktum är att bara en del av plasTransient absorption laser spectroscopy and resonance Raman spectrscopy have been used to study conjugated polymers and oligomers. To extract more information the measurements have been compared to computer simulations and calculations. In order to obtain a better understanding of the role of conformational disorder in the photophysics of light-emitting, conjugated polymers the ultrafast transient
Whilst concurring with the new streams of literature in geography that highlight the importance of face-to-face and ‘buzz’ in the globalizing learning economy, we argue that this literature is misleading on three interrelated counts. Firstly, it conflates face-to-face and buzz; secondly, it fails to distinguish between the importance of face-to-face and buzz for industries drawing on different kno
