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BACKGROUND: Alterations of the charge-selective properties of the glomerular capillary wall are important constituents of the pathogenesis of many glomerular diseases. Thus, differences in the degree of such changes could be of help in understanding the mechanisms governing the transport of macromolecules across the glomerular capillary wall.METHODS: The ratio between urine concentrations of neutr
Electrostatic interactions play crucial roles in protein function. Measuring pKa value perturbations upon complex formation or self-assembly of e.g. amyloid fibrils gives valuable information about the effect of electrostatic interactions in those processes. Site-specific pKa value determination by solution NMR spectroscopy is challenged by the high molecular weight of amyloid fibrils. Here we rep
Group Decision and Negotiation Support Systems need to provide support for different types of communication activities. The purpose of this study is to identify and test cross-linguistic measures for recognition of communication activities in order to provide support for various forms of group decision and negotiation support systems, including e-negotiation support systems. The study uses quantit
The contribution contains a comprehensive presentation of the legal regulations for the indemnification of National Socialist injustice—notably the restitution of property of Jewish victims of the Holocaust—, using the example of the law of the Federal Republic of Germany. It is also devoted to the contextualization of indemnification and reparation policy in terms of international law, public law
Although it is vital for organizations to learn in order to be competitive, efficient, and innovative, it is one of the profound organizational dilemmas: organizations understand and have learnt that it is important to learn and yet it is difficult to ensure organizational learning. This is a personal and reflexive note about what I have learnt from research and practice about various attempts to
PURPOSE: Obesity is associated with a wide range of chronic illnesses and disabilities familiar to rehabilitation researchers and practitioners. Obesity discourse in the area of rehabilitation science and practice is limited.METHOD: A meeting of rehabilitation researchers, practitioners, industry and decision makers was held for the purpose of identifying research and practice priorities in the ar
Biomanufacturing increasingly relies on computational modeling to strengthen process understanding, speed up process development, scale-up and scale-down, improve experimental design, and reduce reliance on costly and laborious wet lab activities. Here we present CADET-Hub, a modular web-based platform for biomanufacturing and stability modeling, developed within the Inno4Vac project. CADET-Hub un
Polycyclic aromatic hydrocarbons (PAHs) of molecular mass (MM) 302 Da comprise numerous structural isomers that are of high concern for human health. Because of their multiplicity, low abundance in the environment, and limited availability of authentic standards, their occurrence, composition, and environmental health risk remain not well characterized. Here we extend the characterization of MM 30
Mesosiderites are rare, differentiated meteorites, so-called stony-iron meteorites—they are impact breccias composed of an unusual mix of crustal basalt and pyroxenite, core-derived metal, but no mantle materials. This odd mixture makes their origin enigmatic and has inspired many different formation theories over the last several decades. Some of the outstanding questions have regarded the origin
Mango production plays a vital role in rural livelihoods in Mozambique, yet post-harvest losses remain high, ranging from 25% to over 50%, due to inadequate preservation methods. Improved solar drying technologies offer a sustainable solution by extending shelf life and enhancing product quality. However, their adoption among smallholder mango farmers remains limited. This study investigates the k
Railways are vital for climate mitigation as a low-carbon mode of transport but must also be resilient to climate change impacts. This study explores dynamic adaptation strategies for coastal railway infrastructure in Sweden, focusing on Trelleborg. Stakeholder workshops informed adaptation pathways using a Dynamic Adaptive Pathways Planning Light (DAPP)-light approach, which enhances stakeholder
In this thesis we study functionals of the type \( \mathcal{K}_{f,A,\b}(\x)= \mathcal{Q}(f)(\x) + \|A\x - \b \| ^2 \), where \(A\) is a linear map, \(\b\) a measurements vector and \( \mathcal{Q} \) is a functional transform called \emph{quadratic envelope}; this object is a very close relative of the \emph{Lasry-Lions envelope} and its use is meant to regularize the functionals \(f\). Carlsson a
Background: The desire to be a mother is much more than a reproductive instinct in pro-baby (pro-natal) society. Motherhood is a complex phenomenon that encompasses psychological, social, and cultural aspects of a woman's holisticwell-being. A woman's socio-cultural visibility is enhanced through motherhood, which also strengthens her psychological status, enriches her spiritual experience, and en
Background: Substance use among older persons occurs with medical and psychiatric comorbidities. This study examined the associations of substance use disorder (SUD), psychiatric, and dual diagnoses with 12-month cumulative hospitalized days, hospital admission rate and number of days to first hospitalization.Methods: The cohort of 3,624 individuals (28.2% women) aged 50 years or older was assesse
