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Background: Since the publication of the EULAR recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in 2016, several randomised clinical trials have been published that have the potential to change clinical care and support the need for an update. Methods: Using EULAR standardised operating procedures, the EULAR task force undertook a systema
Information relating to errors in evapotranspiration (ET) products, including satellite-derived ET products, is critical to their application but often challenging to obtain, with a limited number of flux towers available for the sufficient validation of measurements. Triple collocation (TC) methods can assess the inherent uncertainties of the above ET products using just three independent variabl
Circularity in manufacturing is critical to reducing raw material usage and waste. Ecological embeddedness examines circular relationships intended to benefit both economic actors and the natural environment. By understanding circular relationships in the value chain, manufacturers can formulate strategies that are eco-effective. This work develops and validates an original circularity tool to mea
The use of biofilms to improve the removal of organic micropollutants in waste¬water treatment plants (WWTPs) has been investigated. The work is divided into two parts. In the first part, the use of biofilms for the biological degradation of micro¬pollutants was investigated. In the second part, micropollutant removal was investigated with biofilm processes in combination with ozonation or activat
Removal of carbon dioxide from the atmosphere will be required over the next decades to achieve the Paris Agreement goal of limiting global warming to well below 2°C aiming at not exceeding 1.5°C. Technological and ecosystem-based options are considered for generating negative emissions through carbon dioxide removal (CDR) and several nations have already included these in their Long-Term Low Gree
The Memorial Sloan Kettering Cancer Center (MSKCC) recommendations on prostate cancer screening were developed in response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. The objective of the recommendations is to provide a schema for prostate cancer screening that maximizes the benefits,
Objective. This study proposes a novel technique for atrial fibrillatory waves (f-waves) extraction and investigates the performance of the proposed method comparing with different f-wave extraction methods. Approach. We propose a novel technique combining a periodic component analysis (PiCA) and echo state network (ESN) for f-waves extraction, denoted PiCA-ESN. PiCA-ESN benefits from the advantag
This paper introduces the Lang-Track-App, a smartphone application and backend system to aid second language acquisition researchers in implementing the experience sampling method (ESM). Surveying research participants with the Lang-Track-App multiple times per day can yield exceptionally rich data that can be analyzed in multiple ways. This article explains the different Lang-Track-App components
Several types of Galactic sources, like magnetars, microquasars, novae or pulsar wind nebulae flares, display transient emission in the X-ray band. Some of these sources have also shown emission at MeV-GeV energies. However, none of these Galactic transients have ever been detected in the very-high-energy (VHE; E>100 GeV) regime by any Imaging Air Cherenkov Telescope (IACT). The Galactic Transient
The binding of uropathogenic Escherichia coli to the globo series of glycolipids via P pili is a critical step in the infectious process that is mediated by a human‐specific PapG adhesin. Three classes of PapG adhesins exist with different binding specificities to Galα4Gal‐containing glycolipids. The structural basis for PapG recognition of the human glycolipid receptor globoside was investigated
Objectives To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for the management of axial spondyloarthritis (axSpA). Methods Following the EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment of axSpA. In a task force meeting, the evidence was presented, discussed
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To evaluate the benefits and harms of stem cell-based interventions for the treatment of stroke in newborn infants compared to control (placebo or no treatment) or stem-cell based interventions of a different type or source.
Eukaryotic genomes, particularly animal genomes, have a complex, nonuniform, and nonrandom internal compositional organization. The compositional organization of animal genomes can be described as a mosaic of discrete genomic regions, called "compositional domains," each with a distinct GC content that significantly differs from those of its upstream and downstream neighboring domains. A typical a
The formation of cold gas giants similar to Jupiter and Saturn in orbit and mass is a great challenge for planetesimal-driven core accretion models because the core growth rates far from the star are low. Here we model the growth and migration of single protoplanets that accrete planetesimals and gas. We integrated the core growth rate using fits in the literature to N-body simulations, which prov
