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The development of generic pharmaceuticals includes extensive data on equivalence with the reference listed drug is required by the European medicinal agency (EMA) and the North American equivalent. Equivalence must be proven for rheology, microstructure, and performance. This is a costly and time-consuming process. To reduce the costs, it is of interest to investigate if the release profile (perf
BACKGROUND. Early and accurate detection of infectious respiratory diseases like COVID-19 and tuberculosis (TB) plays a crucial role in effective management and the reduction of preventable mortality. However, molecular diagnostic tests for these infections are expensive and not easily implementable in resource-limited settings, which suffer the majority of the burden. Lung Ultrasound (LUS) presen
Meningsfull förändring har diskuterats i flera studier, med den återkommande frågan om hur den skulle kunna konceptualiseras och bedömas för att identifiera vad som utgör meningsfull förändring och var den uppstår. Tidigare studier har genomfört statistiska analyser baserade på traditionella betygsskalor (d.v.s. PHQ-9) för att bedöma meningsfull förändring. Det finns inga bevis för att tidigare stMeaningful change has been discussed in multiple studies, with the recurring question of how it could be conceptualized and assessed to identify what determines meaningful change and where it occurs. Previous studies have conducted statistical analyses based on traditional rating scales (i.e., the PHQ-9) to assess meaningful change. There is no evidence to be found of previous studies attempting t
IMPORTANCE: Breast cancer (BC) is the second leading cause of cancer death in women, and there is a substantial disparity in BC mortality by race, especially for early-onset BC in Black women. Many guidelines recommend starting BC screening from age 50 years; however, the current one-size-fits-all policy to start screening all women from a certain age may not be fair, equitable, or optimal.OBJECTI
Background and Purpose: Target delineation in glioblastoma is still a matter of extensive research and debate. This guideline aims to update the existing joint European consensus on delineation of the clinical target volume (CTV) in adult glioblastoma patients. Material and Methods: The ESTRO Guidelines Committee identified 14 European experts in close interaction with the ESTRO clinical committee
The European spruce bark beetle (Ips typographus L.) is a major disturbance agent in Norway spruce (Picea abies (L.) Karst) forests in Europe and it is estimated that a changing climate will result in more severe outbreaks in the future. To reduce the risk of large outbreaks it is important to have methods that enable early detection of bark beetle attacks to help forest managers to prevent popula
Many problems in science and engineering involve estimating a dynamic signal from indirect measurements subject to noise, where points can either evolve in continuous time or in discrete time. These problems are often formalised as inference in probabilistic state-space models, which are also frequently assumed to be Markovian. For inferring the value of the signal at a particular point in time, m
The CryoGrid community model is a flexible toolbox for simulating the ground thermal regime and the ice-water balance for permafrost and glaciers, extending a well-established suite of permafrost models (CryoGrid 1, 2, and 3). The CryoGrid community model can accommodate a wide variety of application scenarios, which is achieved by fully modular structures through object-oriented programming. Diff
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau) in plasma exhibit high diagnostic accuracy in distinguishing AD from all other neurodegenerative dise
The goal of person text-image matching is to retrieve images of specific pedestrians using natural language. Although a lot of research results have been achieved in persona text-image matching, existing methods still face two challenges. First,due to the ambiguous semantic information in the features, aligning the textual features with their corresponding image features is always tricky. Second,
The hippocampus is one of the most studied neuroanatomical structures due to its involvement in attention, learning, and memory as well as its atrophy in ageing, neurological, and psychiatric diseases. Hippocampal shape changes, however, are complex and cannot be fully characterized by a single summary metric such as hippocampal volume as determined from MR images. In this work, we propose an auto
We discuss how multinational enterprises (MNEs) can play a leading role and take more responsibility towards reducing inequalities by developing a global sustainability regime. We especially focus on how this may contribute towards the United Nations’ Sustainable Development Goals (UN SDGs). Our purpose is to identify and discuss the components and activities that are needed to develop such a stra
We use a unique source from the Swedish royal demesnes to examine the work and relative wages of women in sixteenth century Sweden, an economic laggard in the Early Modern period. The source pertains to workers hired on yearly contracts, a type more representative for historical labour markets than day-labour on large construction sites, and allows us to observe directly the food consumed by wor
BACKGROUND: Limited evidence exists to guide the management of patients with liver metastases from squamous cell carcinoma (SCC). The aim of this retrospective multicentre cohort study was to describe patterns of disease recurrence after liver resection/ablation for SCC liver metastases and factors associated with recurrence-free survival (RFS) and overall survival (OS). METHOD: Members of the Eur
As organizations continue to adapt and evolve to meet the challenges related to globalization and working with new collaboration technologies to bridge time and space, demands on employees’ time and attention continue to increase. Recognizing this problem and its implications, such as increased employee turnover, many companies are seeking ways to help their employees maintain a healthy balance be
The present invention relates to novel enantiomerically pure intermediary compounds containing specifically substituted tetrahydrofuran structures as well as a method for preparing such intermediary compounds of formula (I), in which the carbon atom in the 2-position has (R)- or (S)-configuration; the substituents in the 2- and 3-positions are trans-related; the substituents in the 3- and 4-positi
By employing a critical perspective toward a broad range of organizational subjects, Mats Alvesson has managed to challenge much of the conventional understanding of modern organizations and, subsequently, produce a series of alternative insights that has substantially developed organizational research and potentially enabled both organizational and societal change. While this has included the est
