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Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter data collection times owing to higher hit rates. Here, a new method of on-chip crystallization is reported which allows the efficient and reproducible

Portugal is located in the southwest of Europe. From economic, cultural, social and environmental point of views, Portuguese coastal areas face multiple challenges related to the coastal management policy, the functionality of the governmental services and the responses to the society, in particular, to the affected citizens. Qualitative and quantitative understanding of the coastal morphological

Nests play a critical role for offspring development across the animal kingdom. Nest quality may contribute to the builder's extended phenotype and serve as an ornament during mate choice. We examined male and female nest choice in the common goby (Pomatoschistus microps), a benthic fish with male-only parental care where females deposit eggs in male-built nests. Using prebuilt nest models, we ind

The aim of this thesis was to contribute to the understanding of aspects related to home, health and participation for community living people with disability and identify different groups with different needs for interventions. Study I used focus groups to explore aspects of importance for participation. Twenty-nine people with Parkinson’s Disease participated in nine focus groups. Studies II-III

Background: Sleep deprivation among adolescents is a major public health issue. Although previous studies have described their sleep habits and the consequences thereof, the voices of adolescents themselves are rarely heard. The aim of this study was to investigate adolescents’ experiences regarding what they perceived as facilitators and barriers for a good night’s sleep. Methods: A qualitative f

The Myc oncoprotein is tightly regulated at multiple levels including ubiquitin-mediated protein turnover. We recently demonstrated that inhibition of Cdk2-mediated phosphorylation of Myc at Ser-62 pharmacologically or through interferon (IFN)-γ-induced expression of p27Kip1 (p27) repressed Myc's activity to suppress cellular senescence and differentiation. In this study we identified an additiona

One reason for the relatively small number of real-world applications of simulation in software engineering is the existing lack of guidance in creating and formulating the related models and in the isolated usage of associated techniques. In order to support both strategic and project management in software organizations, a methodology for integrated measurement, modelling and simulation (IMMoS)

We prove an operator identity for the shift operator in the scale of standard weighted Bergman spaces in the unit disc. This operator identity is then applied in the context of functional calculus for the shift operator and a characterization of harmonic symbol Bergman space Toeplitz operators is obtained generalizing an earlier result by Louhichi and Olofsson. Duality arguments lead to operator i

Video available at: http://www.youtube.com/watch?v=2P8JTEygNcU What are the differences and similarities between the playing techniques of the siku and the quena in Peru and Bolivia, and in addition, the ways these techniques are taught? This is an investigation into the differences and similarities concerning playing techniques of the quena (Andes end-blown flute) and the siku (Andes panpipes) b

After the Cold War the nature and character of international conflict has changed dramatically, from traditional inter-state conflicts to protracted social conflicts. This constitutes a major challenge to contemporary peacebuilders, foremost the UN, but the expanding size and number of peacekeeping missions are threatening to erode UN resources. Peacebuilding scholars have different views on what

The aim of this collaboration, between the division of Thermal Power Engineering and Lunds Energi AB, is to investigate the possibilities of training artificial neural networks (ANNs) with power plant operational data. For this purpose operational data from Lunds Energi's gas turbine GT10B with heat recovery unit (HRU) will be used. Furthermore a model with user interface is created to dem

The purpose of this thesis was to examine the EC Commission's role and policy in the EC control of state aid to companies that risk going out of business. The thesis explores the Commission's role in relation to the Member States as well as to the Community courts. It also examines the Commission's policy towards such aid in order to establish whether the Commission is coherent in its

This thesis has been written as a part of the degree project course in the Master’s program “Sustainable Business Leadership” at the School of Economics and Management, Lund University. The course was based on the methodology of action learning and self-managed learning. The students were all assigned to an in-company project, having a role as consultants. This project constituted the main part of

All over the world there is a shortage of adequate, affordable housing that enables social integration and sustainability. Many individuals and households have access to housing but live in different kinds of involuntary isolation with respect to age, gender, income, culture and ethnic background. There is a lack of housing forms that can contribute to solving these societal challenges through dif

An analytical method is developed for ultrasensitive detection of citrinin using double isothermal amplification and CRISPR-Cas12a. Gold nanoparticles (AuNPs) modified with antigen and thiol-terminated, single-strand DNA (ssDNA) are used as a probe. The antigen-modified AuNPs compete with citrinin to bind to magnetic beads coated with an anticitrinin antibody. After a simple magnetic separation, t

Understanding the inherited nature of how biological processes dynamically change over time and exhibit intra- and inter-individual variability, due to the different responses to environmental stimuli and when interacting with other processes, has been a major focus of systems biology. The rise of single-cell fluorescent microscopy has enabled the study of those phenomena. The analysis of single-c