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Neutrophils are essential for host defense at the oral mucosa and neutropenia or functional neutrophil defects lead to disordered oral homeostasis. We found that neutrophils from the oral mucosa harvested from morning saliva had undergone NETosis in vivo. The NETosis was mediated through intracellular signals elicited by binding of sialyl lewis(X) present on salival mucins to L-selectin on neutrop
BackgroundIntracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view of recent randomized controlled trials (RCTs) of the management of ICH, the European Stroke Organisation (ESO) has updated its evidence-based guidelines for the management of ICH. MethodA multidisciplinary writing committee
We identified the first set of microsatellites for use in the rock firefinch (Lagonosticta sanguinodorsalis). First, we tested existing passerine microsatellite loci for cross-species amplification success in a small sample of rock firefinches and identified 10 loci that were seemingly polymorphic and easy to score. Secondly, we developed and characterized three microsatellite loci de novo from th
To evaluate whether the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant might be effective for migraine prevention.
A search for squarks and gluinos in final states containing jets, missing transverse momentum and no high-p(T) electrons or muons is presented. The data represent the complete sample recorded in 2011 by the ATLAS experiment in 7 TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 4.7 fb(-1). No excess above the Standard Model background expectation is o
Abstract is not available
As an introduction to the volume, this chapter discusses some of the methodological problems involved in assessing the questions of the historical Jesus’ engagement with the Scriptures of Israel. It is claimed that any method for studying the historical Jesus must take into account the two major tasks of Jesus research, viz. ‘authentication’ and ‘interpretation’. The article then discusses how ext
The last ten years have seen a sharp increase in externally supported capacity development initiatives for disaster risk management. However, not all of them have generated sustainable results. The purpose of this paper is to scrutinize the current focus on training as the main tool for capacity development in the context of disaster risk management, and to argue for the necessity to address capac
The use of prosthetic hands are limited partly due to the fact that they lack the provision of sensory feedback to the user. A first step to providing sensory feedback is having adequate sensors in the prosthesis. The WiseSkin project targets the use of artificial skin embedding ultra-low power wireless sensor nodes. This paper provides an overview of the WiseSkin artificial skin for tactile prost
a) The use of a solid phase reaction (silver silicate) for avoiding ortho ester formation in some difficult glycosyl donor/acceptor systems. Thus seven monodeoxygenated analogues of 2-(Trimethylsilyl)ethyl betha-lactoside were synthesiszed. Silver silcate was successfully used in betha 1-4 coupling of 2- and 3-deoxy glucosides to to acetobromogalactose. By similar means, the monodeoxylactosyl brom
In this research, two objectives were pursued. Firstly, to develop an experience-focused approach to design, based on a framework for perceptual product experience, and, secondly, to test and verify the proposed methodology through an interior design study of the Hulme.F1 supercar. In the process, experience design criteria were developed, which served creative and evaluative purposes. The final d
We report on an all-sky search for periodic gravitational waves in the frequency band 50-800 Hz and with the frequency time derivative in the range of 0 through -6 x 10(-9) Hz/s. Such a signal could be produced by a nearby spinning and slightly nonaxisymmetric isolated neutron star in our Galaxy. After recent improvements in the search program that yielded a 10x increase in computational efficienc
Protein kinase B (PKB)/Akt has been strongly implicated in the insulin-dependent stimulation of GLUT4 translocation and glucose transport in skeletal muscle and fat cells. Recently an allosteric inhibitor of PKB (Akti) that selectively targets PKB alpha and -beta was reported, but as yet its precise mechanism of action or ability to suppress key insulin-regulated events such as glucose and amino a
A recent report by Zhao et al. [Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, R. M., Johansson, C. B., Brismar, H., Shupliakov, O., Frisen, J. & Janson, A. M. (2003) Proc. Natl. Acad. Sci. USA 100, 7925–7930] suggests that dopaminergic neurons, the cell type lost in Parkinson's disease, are continuously generated in the adult substantia nigra pars compacta. Using similar methodologica
Adenovirus-based (Ad) vectors are used widely for experimental gene transfer to the CNS. Ad transduce many cell types including postmitotic neurons. However, their use for, CNS gene transfer is limited due to the host immune response elicited. Furthermore, the extensive distribution of the primary cellular receptor for Ad, the coxsackievirus and adenovirus receptor (CAR), allows adenoviral vectors
HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict c
We report new occurrences of ca. 1460 Ma magmatism in western Lithuania, where large volumes of granitoid melts were intruded into host supracrustal and charnockitoid rocks, and formed the Zemaiciu Naumiestis pluton. Numerous granitoids of that age have previously been described from southern Sweden and from the Danish island of Bornholm, but none have been reported from the eastern side of the Ba
