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Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized p
Utilizing passive floodwater harvesting for artificial recharge and spate irrigation in arid and semiarid areas is an opportunity to use marginal water to improve the livelihood of rural community. In the present study, ground- water modeling to estimate recharge, and field experiments for spate irrigation of barley, were carried out to investigate the performance and potential of water harvesting
Objective Longitudinal clinical registry-infrastructures such as Anti-Rheumatic Therapies in Sweden (ARTIS) allow simultaneous comparison of the safety of individual immunomodulatory drugs used in clinical practice, with consistent definitions of treatment cohorts, follow-up and outcomes. Our objective was to assess and compare incidence rates of key safety outcomes for individual targeted synthet
The present thesis consists of four articles that address cognitive-emotional interactions as measured through eye movements and pupil dilation.Social facilitation-inhibition is an effect that describes changes in performance (enhancement or impairment) when individuals complete tasks in social presence compared to when they perform the same tasks in solitary conditions. Along this line, Paper I a
From the horizons of media and communication studies, this article begins with the premise that the media, and the in particular theWeb, as central features of a turbulent late modernity. The Web has become ubiquitous and central to our sense of who we are, how we live, think, relate to others and experience the world. This process of mediatization is complex and historically without parallel; it
TRIM28 is an epigenetic co-repressor protein that mediates transcriptional silencing. TRIM28 participates, together with the large family of Kruppel-associated box domain zinc finger proteins (KRAB-ZFP) transcription factors, in the repression of transposable elements (TE). Recent advances indicate that TRIM28-based repression of TEs occurs in the mammalian brain and may provide beneficial effects
The production of Z0 bosons at large rapidities in Pb–Pb collisions at sNN=5.02TeV is reported. Z0 candidates are reconstructed in the dimuon decay channel (Z0→μ+μ−), based on muons selected with pseudo-rapidity −4.0<η<−2.5 and pT>20GeV/c. The invariant yield and the nuclear modification factor, RAA, are presented as a function of rapidity and collision centrality. The value of RAA for the 0–20% c
Importance: Prostate cancer, a leading cause of cancer death among men, urgently requires new prevention strategies, which may involve targeting men with an underlying genetic susceptibility. Objective: To explore differences in risk of early prostate cancer death among men with higher vs lower genetic risk to inform prevention efforts. Design, Setting, and Participants: This cohort study used a c
The US-Japan alliance established over seventy years ago is typically described by leaders on both sides as the ‘cornerstone of peace and security in East Asia.’ While China and North Korea may not share this positive view of the impact of the alliance on the region, the fact is that few alliances in modern international relations rival the US-Japan one in terms of durability, integration and infl
We systematically fabricate devices and analyse data for vertical InAs/(In)GaAsSb nanowire Tunnel Field-Effect Transistors, to study the influence of source dopant position and level on their device performance. The results show that delaying the introduction of dopants further in the GaAsSb source segments improved the transistor metrics (subthreshold swing and the ON-current performance), due to
Sveriges skogar påverkas av de hastiga globala klimatförändringarna. Inverkan av klimatförändringana syns redan med både ökad frekvens och kraftigare extremväder som stormar, värmeböljor, torka och skyfall. Ett tydligt exempel är den extrema torka som drabbade hela landet år 2018. Till följd av torkan har det bland annat skett en explosionsartad ökning av antalet granbarkborrar som angriper och döA changing climate is expected to lead to more extreme weather events, such as an increased frequency of droughts and forest fires. Changing forest conditions can offer benefits to species such as insects, including bark borers that thrive in warm conditions. Warmer temperatures also favor the acceleration of ozone (O3) production, which can cause stress on vegetation. Vegetation stress can have n
Importance: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown. Objective: To investigate all-cause and cause-specific mortality among a large cohort of individuals wit
Of concern is the fractional Kadomtsev–Petviashvili (fKP) equation and its lump solution. As in the classical Kadomtsev–Petviashvili equation, the fKP equation comes in two versions: fKP-I (strong surface tension case) and fKP-II (weak surface tension case). We prove the existence of nontrivial lump solutions for the fKP-I equation in the energy subcritical case α>45 by means of variational method
