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A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the risk of VTE recurrence and (b) validate a previously described genetic risk score (GRS) and compare its performance with the model developed in this study. Twenty-two SNPs, including establis
Lynch syndrome confers an increased risk for urothelial carcinoma (UC). Molecular subtypes may be relevant to prognosis and therapeutic possibilities, but have to date not been defined in Lynch syndrome-associated urothelial cancer. We aimed to provide a molecular description of Lynch syndrome-associated UC. Thus, Lynch syndrome-associated UCs of the upper urinary tract and the urinary bladder wer
Background The increasing prevalence of atrial fibrillation and novel therapeutic tools to prevent cardioembolic stroke has increased the need for risk markers. Objectives This study explored the relationship between the midregional sequence of pro-atrial natriuretic peptide (MR-proANP) levels with the risk of atrial fibrillation and stroke, and whether measurement of MR-proANP improves the predic
Human pluripotent stem cells (PSCs) are widely used for studying embryonic development, disease modelling, drug discovery and cell therapy development. Using human PSCs as a model has significantly contributed to our understanding of embryonic development and elucidating novel pathological mechanisms as well as developing new drugs. However, there are significant genetic and epigenetic variations
Purpose -The purpose of this paper is to investigate the added value of using temperature-dependent electric and magnetic properties in high-Temperature electromagnetic simulations. Design/methodology/approach - In this work, the electromagnetic properties of Domex 420, SSAB, have been characterized as a function of the temperature, from room temperature to 900°C. The measurement of the electric a
Production of red blood cells relies on proper mitochondrial function, both for their increased energy demands during differentiation and for proper heme and iron homeostasis. Mutations in genes regulating mitochondrial function have been reported in patients with anemia, yet their pathophysiological role often remains unclear. PGC1β is a critical coactivator of mitochondrial biogenesis, with incr
Abstract: Pagan revivalism is a growing trend in the contemporary religious landscape. Is it possible to be a neopagan without disregarding the demands of reason? While outright belief in the old gods seems out of the question, I argue that polytheism represents a live epistemic possibility, and that non-doxastic paganism is therefore a viable option. However, the rational, non-doxastic neopagan s
Lunds universitet har på uppdrag av Naturvårdsverket under 2021 utvärderat metodik för nationell pollinatörsövervakning. Metodiken bygger på rapporten ”Proposal for an EU pollinator monitoring scheme” som tagits fram av en expertgrupp inom EU (Potts m. fl. 2020) och ska kunna ge underlag för uppföljning av pollinatörer på nationell nivå med ett främsta fokus på landskapet utanför områden som omfat
Light microscopy has been a favorite tool of biological studies for almost a century, recently producing detailed images with exquisite molecular specificity achieving spatial resolution at nanoscale. However, light microscopy is insufficient to provide chemical information as a standalone technique. An increasing amount of evidence demonstrates that optical photothermal infrared microspectroscopy
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies and potentially curable only with radical surgical resection at early stages. The tumor microenvironment has been shown to be central to the development and progression of PDAC.A better understanding of how early human PDAC metabolically communicates with its environment and differs from healthy pancreas could help improve
A key policy question is whether continued expansion of university education is beneficial for the marginally eligible student. In this paper we exploit an arbitrary university eligibility rule combined with regression discontinuity design to estimate the causal effect of university attendance on healthcare utilization amongst young adults in Sweden. We find that the eligibility rule leads to a cl
Artikeln behandlar fundamentala prestandabegränsningar för strikt kausala tillståndsskattningar hos linjära system som beskrivs av ett ändligt antal modeller. Systemet antas beskrivas korrekt av en av modellerna, men det är okänt vilken av kandidaterna som är korrekt. Vi ger metoder för att beräkna övre- och undre begränsningar på minimax prestanda, defininerad som förstärkningen från störningar tThis article concerns the performance limits of strictly causal state estimation for linear systems with fixed, but uncertain, parameters belonging to a finite set. In particular, we provide upper and lower bounds on the smallest achievable gain from disturbances to the point-wise estimation error. The bounds rely on forward and backward Riccati recursions-one forward recursion for each feasible m
The role of consumers in a circular economy (CE) is crucial but not well understood in the literature. For consumers to become catalysts in a CE, people need to understand how and under what conditions circular consumption is made possible. This chapter conceptualises the sociomaterial assembling of circular consumption, which refers to the process in which heterogeneous elements – meanings, mater
BACKGROUND: Obesity is an established risk factor for several cancers. Adult weight gain has been associated with increased cancer risk, but studies on timing and duration of adult weight gain are relatively scarce. We examined the impact of BMI (body mass index) and weight changes over time, as well as the timing and duration of excess weight, on obesity- and non-obesity-related cancers. METHODS:
Studies on cultural evolution from archaeology, neuroscience and cognitive semiotics have shown the role of tool making for development of novel cognitive capabilities in early humans. Therefore, it is reasonable to assume that tool making was a cognitive threshold from nonhuman primates to hominins. Tool making begun with rudimentary skills for tool production based on motor patterns, learned soc
Malafouris (2013) proposes that agency is an emergent product of the relational ontology of our material engagement. However, I suggest a distinction between meaning and agency for a better understanding of our relational ontology with things. Meaning is the payoff of the relational ontology, meaning emerges when an agent act within the world. Agency is the capability to act, signify, produce and
