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Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin gene. The expanded polyglutamine (polyQ) repeat of the encoded protein leads to protein misfolding and aggregation, resulting in increased neuronal cell death. DNAJ co-chaperones play a crucial role in transferring misfolded/unfolded proteins to HSP70 chaperones, which play an essential role for protein folding. Here, we
Disease outbreaks and pandemics have long played a role in societal and economic change. However, the nature of such change is selective, meaning that it is sometimes minimal and, at other times, and change or transformation may be unexpected, potentially even reinforcing contemporary paradigms. A comprehensive overview of pandemics and their effects is provided. This is used to help contextualise
This paper presents a systematic discussion of the specifics of communication and work within a virtual development team, which is of crucial importance for competitiveness in the course of globalization. With advances in technology, work within virtual teams is gaining ever-greater importance. However, in this process, special knowledge and skills of virtual team members are a greater obstacle th
To halt the loss of biodiversity and ecosystem services, various actors including companies need to engage, but it is not yet clear what drives voluntary business commitments. We explore leverage points that might increase corporate action for conservation. We apply a structural equation model based on the theory of planned behaviour to analyse data from 618 German companies, collected through an
The combined contribution to highway safety of pavement surface and geometric design indicators is not well investigated due to the complexity of data collection and high time variability of pavement surface conditions. Introduction of high efficiency equipment for comprehensive road surveys is mitigating this issue, expanding possibilities of data integration. In this framework, the present study
The “Fundamental Review of the Trading Book” calculates the capital requirements using Expected Shortfall (ES) backtests since Value at risk (VaR) neglects losses in the tail. Additionally, real estate investments have increased significantly, which warrants an exploration of the asset class. This study applies eight different univariate GARCH models to six distinct property indices; Global, Asia
The development of the new green industries based on standards creates legal issues of the collision between patent law and standardisation processes. Whereas some solutions have already been implemented in the industries like telecommunications, it is of an interest to research on whether these solutions might be used when managing intellectual property rights in the green technologies or there w
Existing pick and place robots are either heavy or have a limited workspace for vertical operations. Since there is no robot today that are both light and have a good vertical workspace, this leads to a gap in the market. With the use of the laws of physics Cognibotics is trying to fill these gaps in the market, by developing new fast and lightweight robots. These new robots are designed to have a
Bricklaying is one of the most accident-prone professions in the construction industry, with heavy and non-ergonomic lifting being a leading cause of sick leave and back problems. Increased automation is expected to reduce the number of work-related accidents while simultaneously improving productivity. Existing solutions are often expensive and inflexible. This thesis investigates how a pick- and
The introduction of the Environmental Transmission Electron Microscope (ETEM) has revolutionized scientific studies by allowing in-situ studies of nano and angstrom scale samples in varying environments. In combination with the introduction of the Microelectromechanical Systems (MEMS) chip the ETEM has become a powerful tool for high resolution imaging of material interaction. However, the MEMS ch
Syftet med denna studie var att undersöka om det fanns ett samband mellan bra taluppfattning och frekvensoberoende (rak dämpning) i hörselskydd. Ett annat syfte var att undersöka om det fanns någon skillnad på taluppfattningen mellan normalhörande och hörselskadade vid objektiva och subjektiva taluppfattningstester med simulerade hörselskydd, där talet var blandat med talvägt brus. I undersökninge
Utveckling och utredning av en automatiserad temperatur kalibrering temperatur fosfor. I denna avhandling presenteras en halvautomatisk temperaturkalibrering för termografiska fosforer. Temperaturdata från termoelement, och fosforensens avklingningskurva registreras och synkroniseras med en temperatur som ökar kontinuerligt över ett bestämt temperaturintervall. Ett LabVIEW-gränssnitt har utvecklaThis thesis achieves a semi-automatic temperature calibration for thermographic phosphors. Thermocouple temperature information and phosphorescence decay curves are recorded synchronized and continuously while the oven temperature is ramped across the entire temperature range. A LabVIEW interface was developed in this context and applied to calibrate two phosphors, CdWO4 and Mg4FGeO6:Mn. These two
Among the multidimensional effects that forced displacement has on population welfare, the economic ones may be measured in various ways: one of them is assessing the effect of being a forced migrant in the probability of accessing the labor market in the destination communities in Colombia. This is obtained through the estimation of a logit model which uses data from the “Survey in marginalized a
Severe environmental degradation worldwide calls for imperative action from human society. Small- and Medium-sized Enterprises (SMEs), which constitute an important component in almost every economic entity in the world, are subject to growing concern, as their environmental performance is essential to regional and global environmental protection and sustainable industrial development. Due to the
In model-based development, floating-point arithmetic is typically used for computations in algorithms and models. However, on many target platforms, there is no support for floating-point computations due to constraints on, e.g., price, size, power consumption, and execution speed. A solution is to use fixed-point arithmetic instead. Manually transforming floating-point code to fixedpoint code is
INTRODUCTION In the last years a lot of researches about source separation have been realized, like extraction of a signal of interest (vocal recognition application), identification of which source gives which sound (motor engine applications) or noise source characterization (environmental application). Most of these techniques for sound source estimation use the signal-subspace approach, where
BACKGROUND: Despite decades of initiatives promoting individual behavior change, obesity rates remain high and continue to rise globally, indicating that what is commonly labelled as “obesity prevention” is not, in practice, preventing obesity. While health promotion strategies and policy interventions have demonstrated improvements in environments, health behaviors, and industry practices, their
