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Objective This study examines whether neighbourhood deprivation increases the risk of giving birth to a small for gestational age (SGA) infant, after accounting for individual-level maternal socioeconomic characteristics. Design An open cohort of women, aged 20-44 years, was followed from 1 January 1992 through 31 December 2004 for first singleton births. The women's residential addresses during t
The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In ad
Maximal oxygen uptake (VO2max) and the amount of type 1 fibers are interrelated but the underlying unifying molecular mechanisms are poorly understood. To explore these mechanisms we related gene expression profiles in skeletal muscle biopsies of 43 age-matched men from published datasets with VO2max and amount of type 1 fibers and replicated some of the findings in muscle biopsies from 154 young
PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-
Electric and magnetic currents are essential to describe electromagnetic-stored energy, and the associated antenna Q and the partial directivity to antenna Q-ratio, D/Q, for arbitrarily shaped structures. The upper bound of previous D/Q results for antennas modelled by electric currents is accurate enough to be predictive. This motivates us to develop the analysis required to determine upper and/o
Popular Abstract in Swedish Denna avhandlings inriktar sig i huvudsak mot utveckling och tillämpning av två nyligen framtagna optiska tekniker för förbränningsstudier. Dessa tekniker kallas mid-infrared polarisationsspektroskopi (IRPS) samt degenererad fyrvågsmixning (IR-DFWM), vilka båda är baserade på infrarött ljus med en våglängd runt 3 mikrometer, samt att teknikernas signalrespons är ickelinThe work reported in this thesis involved the development and application of two novel infrared non-linear laser techniques, namely mid-infrared polarization spectroscopy (IRPS) and mid-infrared degenerate four-wave mixing (IR-DFWM) to combustion diagnostics. These two techniques meet the needs of species concentration detection in combustion environments, especially for those species lacking acce
Recurrent prostate cancer (PCa) remains a major clinical challenge. Invasive and metastatic PCa lesions often exhibit a partial and time-limited response to therapy before the cancer progresses and the patient succumbs to the disease. Despite recent advances in early diagnosis and treatment, approximately one-third of treated patients will relapse and become resistant to currently available treatm
Viral hepatitis remains a global health concern, with growing recognition of the impact of hepatitis A virus (HAV), hepatitis E virus (HEV), and herpesvirus-associated hepatitis, particularly in vulnerable groups. This narrative review from the ESCMID Study Group for Viral Hepatitis (ESGVH) summarizes recent advances and expert perspectives. For HAV, insights into viral evolution, epidemiology, an
This study presents a modular approach for the synthesis of multifunctional affinity sorbents, facilitating molecular separation via magnetic molecularly imprinted polymers. A magnetic propranolol-imprinted polymer (MIP) nanocomposite with superparamagnetic characteristics was synthesized through precipitation polymerization process coupled with coprecipitation methods. Initially, the propranolol-
OBJECTIVES: Implementation of the Stroke Action Plan for Europe (2018-2030) (SAP-E) was initiated in 2019. It is now updated at mid-term to reflect and respond to challenges for stroke care in Europe in 2025. METHODS: The SAP-E covers the entire chain of stroke care. The sections (state of the art, current status and targets) were developed by working groups and finalised based on inputs from the
BACKGROUND: Despite decades of initiatives promoting individual behavior change, obesity rates remain high and continue to rise globally, indicating that what is commonly labelled as “obesity prevention” is not, in practice, preventing obesity. While health promotion strategies and policy interventions have demonstrated improvements in environments, health behaviors, and industry practices, their
Purpose: Radiotherapy (RT) for patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) can be intensified by delivering 6 (6fx/w) instead of 5 (5fx/w) fractions per week. Randomized trials have demonstrated superiority for 6fx/w in patients treated without concurrent chemotherapy (CRT). This real-world analysis compares 6 vs 5 fx/w in LA-HNSCC all-comers, treated predominan
The brain has a tremendous capacity to adapt (i.e., plasticity) to environmental changes or injury. This capacity decreases with age but is never lost. The goal of sensory relearning is to improve hand function by using the dynamic capacity of the brain with the use of guided plasticity (i.e., plasticity used for a therapeutic purpose). After a peripheral nerve injury, no nerve signals are sent fr
Deterministic lateral displacement (DLD) and related microfluidic sorting devices are typically evaluated based on the size distributions of particles collected at each outlet, even though the more relevant measure of performance is the probability that a particle of a given size ends up in a specific outlet. Here, we use Bayes’ rule to infer these size-dependent routing probabilities from experim
