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On-going research aims at answering the question, which satiety signal is the most potent or which combination of satiety signals is the most potent to stop eating. There is also an aim at finding certain food items or food additives that could be used to specifically reduce food intake therapeutically. Therapeutic attempts to normalize body weight and glycaemia with single agents alone have gener

We show that twisting of an infinite straight three-dimensional tube with non-circular cross-section gives rise to a Hardy-type inequality for the associated Dirichlet Laplacian. As an application we prove certain stability of the spectrum of the Dirichlet Laplacian in locally and mildly bent tubes. Namely, it is known that any local bending, no matter how small, generates eigenvalues below the es

BACKGROUND: Recent studies have suggested that reactive oxygen species may be involved in the development of diabetic retinopathy. METHODS: Nitro blue tetrazolium (NBT) staining, a marker of reductants which may be induced by free radicals such as superoxide, and catalase activity, as an indirect measure of hydrogen peroxide (H2O2) generation, were studied in the rat retina in three conditions kno

I Cover Photo: Siti Khatijah Market, Kelantan, Malaysia - Alex Hudson/Unsplash A boy watering plants – Ninja SS/Shutterstock Fisherman walking with fresh tuna – Renata Apanaviciene/Shutterstock Pham Ngu Lao St, Ho Chi Minh City, Viet Nam - Olga Ozik/Pixabay 1 Prosperous and green in the Anthropocene: The human right to a healthy environment in Southeast Asia Claudia Ituarte-Lima Victor Bernard Del

https://rwi.lu.se/wp-content/uploads/2020/12/Prosperous-and-green-in-the-Anthropocene-Report_-index-THAI.pdf - 2026-05-15

To achieve high thermal efficiencies, 30 percent and higher, for small gas turbines a recuperator is mandatory. As the recuperator represents 25–30 percent of the overall machine cost, efforts are now being focused on establishing new low-cost recuperator concepts for gas turbine engines. In this paper the cross corrugated (CC), also called chevron pattern, heat transfer surface is reviewed to ass

Postoperative morbidity after hysterectomy was studied prospectively in 229 consecutive patients in our departments. The incidence of alcohol abuse (> or = 60 gm of alcohol daily) and moderate drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the moderate drinkers and the control group, the alcohol abusers developed significantly more complications (80% versus

In Sweden 1600 patients/year survive cardiac arrest (30-day survival). Post-resuscitation care is complex and aims to stabilize organ function with focus on preventing secondary brain injury. In 2021 The European Resuscitation Council (ERC) and European Society of Intensive Care Medicine (ESICM) published joint guidelines on post-resuscitation care. In this article the Swedish Resuscitation Counci

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

En åpen og opplyst offentlig samtale er en forutsetning for et velfungerende demokrati. Dette idealet fordrer at borgere i stor grad tolererer meningsmotstandere fremfor å utvikle fiendtlige holdninger til dem man er uenig med. En rekke studier fra USA har imidlertid vist at borgere i økende grad er fiendtlig innstilt til velgere de er politisk uenig med (Iyengar et al., 2019). Dette fenomenet er

The effects of flunarizine, a calcium entry blocker, were evaluated in a long-term survival model of ischemia in rats. One group of animals received the drug orally at 24 and 4 h prior to the insult (40 mg·kg-1·dose-1). Another group was given flunarizine following the insult, intravenously at 5 min (0.1 mg·kg-1), and orally at 8 and 24 h (40 mg·kg-1·dose-1). A third group received the solvent for

Ectodermal patterning of the chick embryo begins in the uterus and continues during gastrulation, when cells with a neural fate become restricted to the neural plate around the primitive streak, and cells fated to become the epidermis to the periphery. The prospective epidermis at early stages is characterized by the expression of the homeobox gene DLX5, which remains an epidermal marker during ga

Background and Purpose: Studies of monthly variation in acute stroke care have led to conflicting results. Our objective was to study monthly variation and longitudinal trends in quality of care and patient survival following acute stroke.Methods: Our nationwide study included all adult patients (≥18 years) with acute stroke (ischemic or hemorrhagic), admitted to Swedish hospitals from 2011 to 201

The X-ray scanning microscope PtyNAMi at beamline P06 of PETRA III at DESY in Hamburg, Germany, is designed for high-spatial-resolution 3D imaging with high sensitivity. Besides optimizing the coherent ux density on the sample and the precision mechanics of the scanner, special care has been taken to reduce background signals on the detector. The optical path behind the sample is evacuated up unti

Introduction: Individuals with type 2 diabetes (T2D) are at high risk of experiencing atherosclerotic cardiovascular disease (ASCVD), which is associated with morbidity, mortality and healthcare resource utilisation. Clinical guidelines recommend the use of glucose-lowering medications with cardiovascular benefits in individuals with T2D and cardiovascular disease, but there is evidence that this