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Natural killer (NK) cells are involved both in control of virus infections and in elimination of tumor cells. Killer immunoglobulin-like receptors (KIRs) either activate or inhibit NK cell-mediated cytolysis, protecting healthy cells from destruction while enabling killing of abnormal cells. To investigate whether KIR genes or genotypes are associated with cervical carcinogenesis, a nested case-co
Factor IX is a vitamin K-dependent procoagulant zymogen of a serine protease. In the presence of Ca2+ the active form of factor IX (factor IXa beta) forms a complex with factor VIIIa on suitable phospholipid surfaces such as aggregated platelets. This macromolecular complex rapidly activates factor X. We have previously provided data that suggest an interaction between the NH2-terminal epidermal g
Distinct morphologic and clinical features associated with specific chromosomal abnormalities have been described in subgroups of myelodysplastic syndromes (MDS), which often are losses or gains and only rarely translocations. Among 103 consecutive MDS patients diagnosed and karyotyped at the Albert-Ludwigs University of Freiburg (ALU) between 1993 and 1999, two chronic myelomonocytic leukemias (C
The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco
Background Despite the fact that severe itch is common in many dermatological diseases, the therapeutic arsenal against itching is limited. From neurophysiological experiments, using a new technique termed cutaneous field stimulation, it is known that acute itch can be effectively relieved by stimulation of cutaneous nociceptors. Methods We tested the effects of cutaneous field stimulation (25 mi
This reading addresses the poetics and ideological aspects in the poetic collection for Saeed Al Jariri from the Literary criticism perspective.
(1) Trade-offs between brood size and offspring growth and survival were manipulating the size of 221 great tit Parus major L. broods between 1983 (2) Nestling mass, wing length and tarsus length were inversely related to Hatching date also affected nestling growth, but its effect differed between Intrabrood variability in nestling size increased with brood size. (3) Nestling survival was inversel
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Exercise during cancer treatment improves cancer-related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high- vs low-to-moderate-intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo-)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Cl
Against the backdrop of strong local self-government, this article analyses how local autonomy in Sweden has been affected by the implementation of the European Social Fund (ESF) and the ‘partnership principle’. Guided by theories on collaborative governance, the authors analyse three empirically-derived forms of organizational collaborative arrangements: top-down decision- making, bottom-up regio
The Emergency Management sector in Denmark consists of 24 Municipal Fire and Rescue Services (MFRSs) responsible for providing a justifiable response to prevent, limit, and redress personal injury and damage to property and the environment arising from accidents and disasters. This research investigates how the MFRSs throughout Denmark define and direct the prevention and response parameters of qu
Numerous recent studies project that ‘climate engineering’ technologies might need to play a major role in the future. Such technologies may carry major risks for developing countries that are often especially vulnerable to, and lack adaptive capacity to deal with, the impacts of such new technologies. In this situation, one would expect that developing countries—especially the least developed cou
