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Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (

In the present study, the enzyme thymidine kinase 1 from tomato (ToTK1) was expressed in E.coli and purified to near homogeneity by means of affinity chromatography. However, purified ToTK1 of bacterial origin displayed no substantial catalytic activity. Expression was also attempted in insect cells using the baculovirus expression vector system (BEVS). Significant TK activities were detected in t

This thesis covers specification and development of a distributed measurement system intended for CAN bus. It was completed at Scania CV, Södertälje in collaboration with Lund University. The goal of the thesis is to specifiy and develop a distributed measurement system that helps Scania with acquisition of functional and electrical data. Several topics are adressed such as filtering, at what spee

This thesis explores the classification of savannah trees using EnMAP hyperspectral and Sentinel-2 multispectral satellite data using a Random Forest classifier. The study aimed to assess if the increase in spectral information from the hyperspectral data gives an increase in classification performance, to find the advantages and limitations to hyperspectral data compared to multispectral data and

Myoelectric prosthetics utilize machine learning(ML) algorithms to translate surface electromyography(sEMG) signal patterns into movement, allowing patients to easily control their prosthesis. While the use of conventional ML algorithms has been effective within these prosthetics, challenges still remain in terms of classification accuracy and computation speed. It was hypothesized that Kolmogorov

Purpose: The purpose of this study is to explore how consumers navigate and justify their consumption habits while striving for a more sustainable identity. The study examines the internal dilemmas that arise when sustainable values confront the realities of identity expression and social influence. Methodology: A qualitative research approach was adopted, in the form of in-depth interviews, invo

Impact investing is a recently emerged field which aims to combine the goal of achieving financial returns with positive environmental or social impact. The documented loss of biodiversity has caused the emergence of many corporate environmental impact reporting frameworks, which have sometimes been criticized for their lack of biodiversity-outcome indicators. This study aims to take stock of the

The objective of this thesis is to investigate the feasibility of constructing temporary warehouse halls using glulam (glued laminated timber) frames, as well as to explore alternative solutions to PVC fabric for roofing and walls. The background is an increasing demand for temporary and flexible ware- house structures across several industries, along with a growing interest in environmentally fr

We live in an increasingly individualistic society where involuntary loneliness, especially among older adults, has become a growing issue. In Sweden, where single-person households are common, many seniors, particularly those over 65 who live alone, report feeling lonely. At the same time, children are growing up with limited contact with older generations, as everyday interactions between age gr

Industrial pasteurisation is a heat-intensive process with significant potential for decarbonisation. This study investigates how open-source Modelica libraries can be adapted for industry, especially for food industry, and integrated to replace fossil-based thermal systems. Investigations are done to evaluate models of heat pumps, thermal energy storage, specifically the stratified tank, and sol

Network cameras observe physical spaces but lack an inherent understanding of the scenes they see. This thesis presents a pipeline for floor and wall instance segmentation from a single uncalibrated RGB image, requiring no scene-specific prior information such as camera intrinsics, depth sensors, floor plans, or labelled floor and wall data for training. The detected instances are intended to supp

Electronic Image Stabilization is a method to digitally stabilize a video feed to remove unwanted motion by transforming the image. The aim is to create a better viewing experience, reduce bitrate, and simplify further video analytics. This thesis explores different algorithms to stabilize Pan-Tilt-Zoom surveillance cameras made by Axis Communications. Many scenarios are investigated, but the case

Förarapplikationer används i allt större utsträckning hos yrkesförare för att stödja företags ruttplanering, orderhantering, dokumentation och intern/extern kommunikation. När förare behöver läsa, tolka och/eller interagera med information i situationer kopplade till körning kan dessa system även skapa visuell, manuell och kognitiv distraktion, vilket ökar risken för trafikrelaterade skador. DettaDriver applications are increasingly used in professional driving to support route planning, order management, documentation, and communication. When drivers need to read, interpret, or interact with information in close proximity to driving, these systems can also create visual, manual, and cognitive distractions, increasing traffic safety risk. This master's thesis was conducted in collabora

The Period genes (Per) play essential roles in modulating the molecular circadian clock timing in a broad range of species, which regulates the physiological and cellular rhythms through the transcription-translation feedback loop. While the Period gene paralogs are widely observed among vertebrates, the evolutionary history and the functional diversification of Per genes across vertebrates are no

This master’s thesis has examined the feasibility of an accumulator-based actuation method for the BorgWarner (BW) electric torque vectoring and disconnect (eTVD) system. The requirements for the proposed concepts were defined based on the performance of the baseline eTVD and served as reference criteria throughout the development process. A strong emphasis was placed on reducing system complexit

Patients admitted to intensive care after cardiac arrest are at risk of circulatory shock and early mortality due to cardiovascular failure. The aim of this study was to evaluate the ability of the veno-arterial pCO2 difference (∆pCO2; central venous CO2 – arterial CO2) and lactate to predict early mortality in postcardiac arrest patients. This was a pre-planned prospective observational sub-study

We study the long-time behavior of solutions to quasilinear doubly degenerate parabolic problems of fourth order. The equations model, for instance, the dynamic behavior of a non-Newtonian thin-film flow on a flat impermeable bottom and with zero contact angle. We consider a shear-rate dependent fluid the rheology of which is described by a constitutive power law or Ellis law for the fluid viscosi

We construct a coarse-grained, structure-based, low-resolution, 6-bead flexible model of bovine serum albumin (BSA, PDB: 4F5S), which is a popular example of a globular protein in biophysical research. The model is obtained via direct Boltzmann inversion using all-atom simulations of a single molecule, and its particular form is selected from a large pool of 6-bead coarse-grained models using two