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Obesity is one of the principal human health problems and one of the main treatments against it is the inhibition of pancreatic lipase, the main responsible enzyme of lipid digestion. For that purpose, previous studies have tested several phenolic compounds against lipase, without considering their aggregation behavior in aqueous solutions. Because of this, the present study focuses on understandi
Radiative lifetime measurements have been performed, with a time-resolved laser-induced fluorescence technique, for 12 levels of Os I and for 9 levels of Os II. For 9 levels of Os I and 4 levels of Os II, there were no previous experimental data available. From a comparison with new theoretical calculations, taking configuration interactions and core-polarization effects into account, it has been
A population-based serosurvey of Human Herpesvirus type 8 (HHV8) in Vasterbotten county, an area of Northern Sweden with high incidence of Kaposi's Sarcoma, was conducted. Serum samples from an age- and sex-stratified random sample of 520 subjects (260 men and 260 women) participating in a population-based biobanking project were tested for antibodies against HHV8, using a sensitive indirect immun
Background Low competence levels among nursing staff have been associated with lower quality of elderly care. However, interventions aimed at improving nursing staff competence have not always been evaluated for their possible impact on the quality of elderly care. An educational intervention in the form of a workplace “toolbox” was shown to have positive effects on nursing staff competence and wo
Rinodina pityrea and R. colobina are reported as two distinct species with differing ecology and morphological characters. Molecular analysis of their ITS and mrSSU genes show that R. pityrea and R. colobina are two clearly separated species. Furthermore, the two species are morphologically and geographically distinct in the Nordic countries and can usually be recognized with a hand lens rather th
A search for new phenomena has been performed in final states with at least one isolated high-momentum photon, jets and missing transverse momentum in proton–proton collisions at a centre-of-mass energy of s = 13 TeV. The data, collected by the ATLAS experiment at the CERN LHC, correspond to an integrated luminosity of 139 fb−1. The experimental results are interpreted in a supersymmetric model in
We present a method to produce small pitch gratings for X-ray interferometric imaging applications, allowing the phase sensitivity to be increased and/or the length of the laboratory setup to be minimized. The method is based on fabrication of high aspect ratio silicon microstructures using deep reactive ion etching (Bosch technique) of dense grating arrays and followed by conformal electroplating
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. We identified CHIP using whole-exome sequencing data of blood DNA and modeled as a composite, considering all driver ge
The first samples collected by the Perseverance rover on the Mars 2020 mission were from the Maaz formation, a lava plain that covers most of the floor of Jezero crater. Laboratory analysis of these samples back on Earth would provide important constraints on the petrologic history, aqueous processes, and timing of key events in Jezero crater. However, interpreting these samples requires a detaile
The single nucleotide polymorphism 1858C> T in the PTPN22 gene is associated with type 1 diabetes (T1D) in several populations. Earlier reports have suggested that the association may be modified by human leukocyte antigen (HLA), as well as by islet autoantibodies. In a large case-control study of Swedish incident T1D patients and controls, 0-34 years of age, we tested whether the odds ratio (OR)
Abstract Background Gender specific outcome for children with anorectal malformations (ARM) is rarely reported although it is important for medical care and in parent counseling. Purpose To assess bowel function according to the Krickenbeck system in relation to ARM-subtype, gender and age. Method All children born with ARM in 1998–2008 and referred to two centers in two different countries wer
Successful coordination of Requirements Engineering and Testing (RET) is crucial in large-scale software engineering. If the activities involved in RET are not aligned, effort is inevitably wasted, and the probability of delivering high quality software products in time decreases. Previous work has identified sixteen challenges in aligning RET in a case study of six companies. However, all six cas
This thesis examines silence in modernist fiction, explaining how it forms a central aspect of realism in the modernist novel. It is based on close readings of the form and function of silence in the works of Dorothy Richardson, James Joyce, and Virginia Woolf. The study proposes that silence as part of a text’s soundscape and silence as part of its mode of literary expression are related in moder
Quality requirements complement functional requirements with information on the target quality levels of software functions or emergent system quality aspects. In release planning the allocation of development effort in further investments into product enhancements, new or enhanced functions are competing with quality improvements for limited resources. When setting balanced quality targets for de
