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Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. Currently the only treatment for liver cirrhosis is liver transplantat

The dominant role of technology in contemporary societies requires the public to rely on individuals with specialized knowledge to invent, design, manufacture and maintain increasingly complex artifacts and networks. As Stilgoe et al. (2006: 16) note, “Our everyday lives are played out through a series of technological and expert relationships.” In spite of the increasing reliance on technologies

The Cenozoic Himalaya-Tibet orogen is generally regarded as the archetypal continental collision zone and is often used as an analogue for interpreting ancient orogenic events. However, given the wide diversity observed in present-day collisional mountain belts, the extent to which such inferences can be made remains debated. In this Review, we compare the metamorphic and magmatic record of the Hi

The purpose of this article is to contribute to a refined perspective on how the practices of everyday life can challenge existing spatial scale relations, as well as produce new ones, and how this in turn can be addressed by planning. The investigation is based on a discussion of empirical studies dealing with the role of migrants in processes of place-making and urban transformation. In the arti

The Cherenkov Telescope Array (CTA) is a next generation ground-based very-high-energy gamma-ray observatory that will allow for observations in the >10 GeV range with unprecedented photon statistics and sensitivity. This will enable the investigation of the yet-marginally explored physics of short-time-scale transient events. CTA will thus become an invaluable instrument for the study of the phys

This article introduces the Framework for Integrating Rights and Equality (FIRE): a transdisciplinary framework that builds synergies between human rights-based (HRBA) and gender equality approaches to disaster risk reduction (DRR) and climate change adaptation (CCA). It describes how FIRE has been developed, tested and refined over the course of a five-year regional learning and technical coopera

Ecosystem services (ES) are an increasingly popular policy framework for connecting biodiversity with human well-being. These efforts typically assume that biodiversity and ES covary, but the relationship between them remains remarkably unclear. Here we analyse >500 recent papers and show that reported relationships differ among ES, methods of measuring biodiversity and ES, and three different app

Psychosocial treatments improve outcome in Pediatric bipolar disorder (PBD), but few are developed specifically for adolescents and none has been evaluated in Europe. This study evaluates family-focused cognitive-behavioral therapy for adolescents (ages 13-18) with PBD in routine psychiatric care in Sweden, adapted for teenagers in a European setting from the Child and Family-Focused Cognitive Beh

Complex scientific questions often require collaboration between scientists to access scientific instruments (deS. Price, Res Policy 13:3–20, 1984; Shrum et al. 2007, Structures of scientific collaboration, The MIT Press, 2007), knowledge and social capital from scientists outside of their immediate networks (Burt, Am J Sociol 110:349–399, 2004; Collins, Tacit and explicit knowledge, University of

The mucolytic human gut microbiota specialist Akkermansia muciniphila is proposed to boost mucin-secretion by the host, thereby being a key player in mucus turnover. Mucin glycan utilization requires the removal of protective caps, notably fucose and sialic acid, but the enzymatic details of this process remain largely unknown. Here, we describe the specificities of ten A. muciniphila glycoside hy

Urban green spaces are important for climate change adaptation, in particular to reduce the negative impacts of heat waves on human well-being. However, in growing cities urban green spaces are under pressure due to increasing housing demand and densification. Municipalities face the challenge of addressing both the housing shortage and the need for climate change adaptation on limited space. This

The snowmelt runoff process from small basins is discussed. A differentiation is made between overland flow in the snowpack and groundwater flow induced by infiltrating meltwater. The effect of variations of the snowmelt intensity on streamflow is studied. It is shown that the runoff is high from the first day of snowmelt runoff if the streamflow is caused by overland flow, and that there are pron

I report on the opening ceremony of the International Year of Light and Light-based Technologies 2015 (IYL2015), which took place at the UNESCO headquarters in Paris, France, on 19-20 January 2015. Over the two days, more than 1000 participants from all over the world learned more about the fundamental properties of light and advanced photonics applications, the history of optics and its applicati

Since the 1970s critical marketing scholars have called for systemic change to overcome the ethical problems generated by consumption, such as unsustainable resource use, industry-induced climate change, and social inequities. Mainstream marketing research has instead problematised the individual consumer and sought ways to diminish the so-called gap between ethics and consumption. The current con