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The “Warburg effect”, a metabolic adaptation observed in dividing cells, involves a shift from mitochondrial oxidative phosphorylation to cytoplasmic glucose metabolism. This metabolic process is characterized by increased cellular uptake of glucose and glutamine, elevated intracellular pH and sodium levels, enhanced protection against oxidative stress, altered autophagy, and increased lactate pro
The life of Jerome of Stridon (d. 419/420), who was regarded as a father of the church and one of the most important authorities in the Middle Ages, has often been depicted as highly controversial: In modern reconstructions, Jerome is typically described as an outsider, constantly involved in controversies and frequently criticized and questioned by his contemporaries. This begs the question of ho
In 1634, silver was found in inland Sápmi, on the present border between Norway and Sweden. The Swedish Crown had the ore extracted and a works for refining the silver was established in Silbojokk the following year. During the coming decades, two more works and many mines were opened in Sápmi. Sámi, Swedish and Dutch/German migrant workers were employed under restrictive conditions and in a harsh
This paper investigates how bank liability regimes shaped liquidity responses during the Great Depression in Sweden. Using monthly balance sheet data (1929-1934), we find that unlimited liability banks increased liquid assets more aggressively in response to monetary tightening and crisis, reallocating away from securities. In contrast, limited liability banks exhibited weaker responses. Mechanism
Damage, failures, and defects in buildings create an enormous cost for stakeholders. This study examined technical aspects of inadequate management and maintenance causing moisture and indoor environment related damage instances. Using a dataset of 2100 diagnosed causes of damage based on real damage investigations carried out in Sweden, several of the factors causing damage were identified. The c
How do new companies attempt to captivate customers in a food market they are substantially seeking to transform? Plant-based meat has been marketed as a revolutionary food product that will not only transform markets but also provide better health and reduced environmental harms. Building on conceptualizations of captivation, we analyze video ads from leading brands. Our results highlight four mo
Purpose: – We sought to develop an equation, the Alma College Estimation (ACE) equation, to estimate survival equivalent to the Duke treadmill score (DTS) and Duke nomogram. Methods: – Combinations of ST segment deviation (0, 1, 2, 3, and 4 mm), angina (0 = none, 1 = nonlimiting, and 2 = limiting), and metabolic equivalents of task (2–20) were graphed on the Duke nomogram, and the ACE equation was
Mobile genetic elements such as conjugative plasmids are responsible for antibiotic resistance phenotypes in many bacterial pathogens. The ability to conjugate, the presence of antibiotics, and ecological interactions all have a notable role in the persistence of plasmids in bacterial populations. Here, we set out to investigate the contribution of these factors when the conjugation network was di
Background Psychological stress is an independent risk factor for cardiovascular disease (CVD), but the mechanism by which stress is associated with CVD is not entirely understood. Although genetic factors are implied in both stress responsivity and cardiovascular reactivity, no studies to date have investigated their interactions with stress for cardiovascular end points. The objective was to elu
Background Psychological stress is a modifiable risk factor for health outcomes and can be managed through coping mechanisms. Biological and behavioral hypotheses have been proposed to explain the association between stress coping strategies and cancer outcomes. Methods The Japan Public Health Center-based study asked questions on coping behaviors in its 10-year follow-up survey. 55,130 subjects a
working paper no 34
The Swedish Pompeii Project started in 2000 as a research and fieldwork activity initiated by the Swedish Institute in Rome. The aim was to record and analyze an entire Pompeian city-block, Insula V 1. Since autumn 2011 a new branch of advanced digital archaeology, involving 3D reconstructions and documentation methods, was added to the project agenda. The insula was completely digitized using las
Female religious communities, and later also convents, accompanied the return of the Roman Catholic Church to the Nordic countries in the middle of the nineteenth century. These religious communities were mostly so-called active orders or congregations, who helped in parishes or ran private schools, orphanages or nursing homes. In the 1930s there were nearly 1,400 Catholic sisters working in Scand
Acceptance, attrition and outcome of the same outpatient treatment programme for alcoholics was studied first in a non-randomized and later in a randomized study. There was a lower (15%) rate of acceptance and a higher (19%) rate of attrition in the randomized study. Among treatment completers drinking outcome during the third year after commencement of treatment did not differ between the non-ran
In this article we seek to extend recent debates on how the promotion of self-reliance through vocational training and entrepreneurship has become the new neoliberal mantra among refugee-supporting agencies, policymakers and humanitarian actors. More specifically, we do so in the context of corporate and celebrity-endorsed humanitarian partnerships and initiatives that single out refugee women and
