Filtyp
Human cystatin C, a member of the cysteine proteinaseinhibitory family, is produced by all nucleated cells and has important roles in regulating natural immunity. Nematode homologs to human cystatin C have been shown to have anti-inflammatory effects on monocytes and to reduce colitis in mice. In Crohn’s disease, pathogenic activated monocytes help drive inflammatory processes via the release of p
Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal
Aims/hypothesis: Variations in FTO are the strongest common genetic determinants of adiposity, and may partly act by influencing dopaminergic signalling in the brain leading to altered reward processing that promotes increased food intake. Therefore, we investigated the impact of such an interaction on body composition, and peripheral and brain insulin sensitivity. Methods: Participants from the T
Secretagogin is a calcium-sensor protein with six EF-hands. It is widely expressed in neurons and neuro-endocrine cells of a broad range of vertebrates including mammals, fishes and amphibia. The protein plays a role in secretion and interacts with several vesicle-associated proteins. In this work, we have studied the contribution of calcium binding and disulfide-bond formation to the stability of
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive vibrational fingerprinting technique widely used in analytical and biosensing applications. For intracellular sensing, typically gold nanoparticles (AuNPs) are employed as transducers to enhance the otherwise weak Raman spectroscopy signals. Thus, the signature patterns of the molecular nanoenvironment around intracellular unlabeled A
Extracts of Alzheimer's disease (AD) brain that contain what appear to be sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimers potently block LTP and impair memory consolidation. Brain-derived dimers can be physically separated the Aβ monomer, consist primarily of Aβ42, and resist denaturation by chaotropic agents. In nature, covalently cross-linked Aβ dimers could be generated in two ways:
Eltringham's organ is a club-like projection from the posterior margin of hind-wings of some myrmeleontid insects. It bears laterally directed setae, each having a specialized epidermal cell beneath, which gives off secretion into a sub-setal lumen. The lumen continues into the wall of the moat-like socket of the setae. Eltringham's organ fits into an excavation of the lateral body wall connected
A recapitulation of the history of the the great library of the Bohemian statesman Peter Wok Rosenberg, which after his death entered the Emporor’s treasures in Prague, but was captured by the Swedish Army at the end of the Thirty Years War and brought to Stockholm, where parts still reside in the Royal Library. Its white bindings are a prominent feature of the Rosenberg collection.
This paper shows the importance of adopting a wide perspective when analysing packaging and logistics and of having an understanding of how the package is related to logistics activities. It also exemplifies and discusses the importance of understanding the logistics chain and making sure that all parts of the logistics chain work together and support each other. The packages are good examples of
This thesis investigates the role of migration in international trade within the framework of behind-the-border trade barriers and firm behavior. In addition to the introduction, which provides a context to the analysis, it consists of four essays. The first essay, titled ‘Migration as Trade Facilitation? Investigating the Links Between International Trade and Migration,’ examines the cross-countr
Unemployment and precarity have become key features of 21st century work. Employability is presented as a solution to these issues. Individuals are exhorted to manage their employability, in order to be able to exercise choice in the labour market. While employability is individualsʼ responsibility, governments, employers and educational bodies simply provide opportunities for its development. Hig
Since May 1998 Scandinavian group researchers and social psychologists have met bi-annually for what has to be called the GRASP conference. GRASP originally stood for ”Group as Paradox”. The first five conferences were held in Linköping, Lund, Stockholm and Skövde and, again, Linköping. The sixth conference was organized at Lund University May 15-16, 2008 under the auspices of the network Organi
