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When initiating the research for my graduate paper I had a rather straightforward intent in mind. It was to determine if the research being conducted in the bio-health related field was negatively affected by the patent system. If the research was delayed by the patent system I wanted to apprehend why. I came to the conclusion that over the years the sphere where the exchange of intellectual prope
Self-monitoring is essential for effectively regulating learning, but difficult in visual diagnostic tasks such as radiograph interpretation. Eye-tracking technology can visualize viewing behavior in gaze displays, thereby providing information about visual search and decision-making. We hypothesized that individually adaptive gaze-display feedback improves posttest performance and self-monitoring
This study examines the first-hand sources of Kemalism to understand how and to what extent the French Revolution inspired the Kemalist elite and influenced Kemalism during the early republican period. In the literature, there is a general perception that the French Revolution and Jacobinism were highly influential on the Kemalists, but this perception mainly depends on broad interpretations witho
Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac
Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is the cardiac manifestation of transthyretin amyloidosis (ATTR). The aim of this study was to estimate healthcare resource use for ATTR-CM patients compared with heart failure (HF) patients, in Denmark, Finland, Norway, and Sweden. Methods and results: Data from nationwide healthcare registers in the four countries were used. ATTR-CM patients w
Aims/hypothesis: The aim of this work was to study the incidence over time of lower extremity amputations and determine variables associated with increased risk of amputations in people with type 1 diabetes. Methods: Individuals with type 1 diabetes registered in the Swedish National Diabetes Registry with no previous amputation from 1 January 1998 and followed to 2 October 2019 were included. Tim
Hydrological processes in a watershed consist of multiple sub-processes (such as plant growth, evapotranspiration, water yield, and soil–water balance) that have complex interactions. The common practice of calibrating hydrological models against only a single variable (e.g., streamflow) can lead to parameter uncertainty (also known as equifinality), resulting in significant uncertainties in the r
A search for dark-matter particles in events with large missing transverse momentum and a Higgs boson candidate decaying into two photons is reported. The search uses 139 fb−1 of proton-proton collision data collected at s = 13 TeV with the ATLAS detector at the CERN LHC between 2015 and 2018. No significant excess of events over the Standard Model predictions is observed. The results are interpre
Binary star systems are assumed to be co-natal and coeval, and thus to have identical chemical composition. In this work, we aim to test the hypothesis that there is a connection between observed element abundance patterns and the formation of planets using binary stars. Moreover, we also want to test how atomic diffusion might influence the observed abundance patterns. We conduct a strictly line-
During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemota
Severe COVID-19 is characterised by immunopathology and epithelial injury. Proteomic studies have identified circulating proteins that are biomarkers of severe COVID-19, but cannot distinguish correlation from causation. To address this, we performed Mendelian randomisation (MR) to identify proteins that mediate severe COVID-19. Using protein quantitative trait loci (pQTL) data from the SCALLOP co
The roughly 600 km long Central Cordillera of Colombia shows a varied tectonic, magmatic, and exhumation history, despite the reasonably homogenous appearance concerning topography, outcropping lithologies, and strike. Here we show with new geo-thermochronological data the thermal evolution of the southern Central Cordillera since the Early Jurassic. Extensive Jurassic magmatism is recorded by U–P
This chapter is concerned with the Nordic region as a context fostering a distinct place branding scholarship and practice. The endeavour goes beyond demonstrating particular practices or significance of branding phenomena in this region. Rather, the aim is to compile and structure a growing body of research dealing with Nordic place branding and assess its global relevance and academic implicati
The Middle East and Sorth Africa (MENA) is a large, complex, and diverse region and is viewed as a huge centre of cultural and travel influence. Nevertheless, the region has been plagued by geopolitical tensions, political turmoil, instability, and conflict over the decades. The conflict-ridden and controversial image of the region in many tourism-generating markets has negatively affected the flo
BACKGROUND: Serial assessment of phosphorus is currently recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, but its additional value versus a single measurement is uncertain. METHODS: We studied data from 17 414 HD patients in the Dialysis Outcomes and Practice Patterns Study, a prospective cohort study, and calculated the area under the curve (AUC) by multiplying the
Introduction: Sclerostin, an inhibitor of bone formation, has emerged as a potential negative regulator of glucose homeostasis. We aimed to investigate if serum sclerostin associates with insulin sensitivity, beta cell function, prediabetes or metabolic syndrome in healthy men. Materials and methods: Serum sclerostin was measured in basal and insulin-stimulated samples from 526 men without diabete
