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OBJECTIVE: There is growing interest in how peers' genotypes may influence health (i.e., peer social genetic effects). The authors sought to clarify the nature of peer social genetic effects on risk for drug use disorder, alcohol use disorder (AUD), major depression, and anxiety disorder. METHOD: Cox models were used with data from a population-based Swedish cohort (N=655,327). Outcomes were drug

Repair and replacement strategies using cell replacement or viral gene transfer for neurologic diseases are becoming increasingly efficacious with clinically meaningful benefits in several conditions. An increased understanding of disease processes opens up opportunities for genetic therapies and precision medicine methods aiming at disease modification or repair of lesioned neurologic structures.

Background: The affective profiles model has been used in several studies investigating individual differences in, for example, well-being and ill-being. The model categorizes individuals in four profiles based on the balance of high/low positive/negative affect: (1) self-fulfilling (high positive affect, low negative affect); (2) high affective (high positive affect, high negative affect); (3) lo

This review examines the hidden and invisible labor humans perform to enable robots to function as agents within Human-Robot Interaction (HRI). While robot agency is often framed as internal and autonomous, this perspective overlooks the relational dynamics that sustain robot functionality in real-world settings. Drawing on feminist theory, the review highlights how humans frequently share the res

Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood mononuclear cells) stimulated by cancer serum factors or specific peptides produce interleukin-6 (IL-6). Immunoregulatory albumin neo-structures and peptides wer

Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of

Introduction: Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cancer immunity. The ambiguous morphological definition of TLS makes it challenging to ascertain their clinical impact on patient survival and response to immunotherapy. Objectives: This study aimed to characterize TLS in hematoxylin-eosin tissue sections from lung can

Two cast Mg–Al–Ba–Ca alloys, DieMag633 and DieMag844, are the focus of this study. Their microstructureMicrostructure consists of a eutectic Ca-rich structure, the lamellar Al2Ca, and of a hard, compact and brittle interdendritic Ba-rich phase, the Mg21Al3Ba2 phase. Both phases have a much higher hardness than the α-Mg matrix and strongly influence the crack propagationCrack propagation under quas

The concept of the rule of law has been a central issue in China for the past two decades, gaining even greater prominence under Xi Jinping’s leadership. This article examines the development of the rule of law in China, drawing on insights from local Chinese scholarship as a vital source for understanding the situation. By analyzing the most cited research articles in the China National Knowledge

The brain has a tremendous capacity to adapt (i.e., plasticity) to environmental changes or injury. This capacity decreases with age but is never lost. The goal of sensory relearning is to improve hand function by using the dynamic capacity of the brain with the use of guided plasticity (i.e., plasticity used for a therapeutic purpose). After a peripheral nerve injury, no nerve signals are sent fr

BACKGROUND: In patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and who are treated with direct oral anticoagulants (DOACs), dual antithrombotic treatment without aspirin is recommended. Evidence comparing P2Y 12 inhibitor strategies in this setting is limited. AIMS: This study aimed to compare outcomes with ticagrelor versus clopidogrel as part of du

Background: Progressive respiratory failure is the leading cause of death in patients with severe COVID-19. Histopathological findings in acute severe COVID-19 are foremost based on post-mortem findings. On computed tomography (CT), acute COVID-19 pneumonia is characterized by ground-glass opacities (GGOs) and, later, by a crazy-paving pattern (CPP) and consolidations. Purpose: To investigate if C

In this study we compared the latencies and amplitudes of pupillary light responses, recorded by a Tobii Pro Spark eye-tracker and a setup combining PupilEXT, a free open-source software for pupillometry, with an industrial camera. Pupil size was recorded simultaneously with both systems while illumination was provided by the Spark. Results show that neither pupillary response latencies nor amplit

The article summarizes the results of work since 2010 to develop non- destructive energy dispersive X-ray fluorescence analysis (EDXRF) as a non-destructive method for determining the provenience of flint in northern Europe. Some 40 localities from Sweden, Denmark, Germany, Poland, and Ukraine have been sampled and analyzed. Trace elements have not proven particularly effective in drawing distinct

The User Compass Chart (UCC) was used for eliciting middle-age subjects’ experiences of 33 photo-represented easy chairs, including consumer products and chairs designed for nursing-homes as well as institutions in general. The chairs were represented in black and white photos measuring 50 x 50 mm. The vectors used in the chart were most inviting - most repellent and most homelike- most nursing-ho

In vehicular communications systems the channel estimation filter suppresses the additive noise in channel estimates obtained from pilot symbols. Vehicular channels show local stationarity for a finite region in time and frequency, only. Such a process can be divided into consecutive stationarity regions, allowing to calculate a Wiener filter. We analyze the increase of the mean square error (MSE)

Non-responders to checkpoint inhibitors generally have low tumor T cell infiltration and could benefit from immunotherapy that activates dendritic cells, with priming of tumor-reactive T cells as a result. Such therapies may be augmented by providing tumor antigen in the form of cancer vaccines. Our aim was to study the effects of mitazalimab (ADC-1013; JNJ-64457107), a human anti-CD40 agonist IgG

Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated. Here, we demonstrate that peripheral cross-tolerance to intestinal epithelial cell (IEC)–derived antigen involves the generation and suppressive function of FoxP3+CD8+

I discuss the dilution of responsibility of action and the idea of a symmetrical relationship between artefacts and humans. In doing so, I argue that meaning making is an activity unilaterally performed by agents, leading to an asymmetrical relationship between agents and artefacts. Therefore, the study of the one who is responsible for the action, the meaning-maker (with the capability to act) is