Sökresultat

Background: Interleukin-6 is dysregulated in multiple pathological conditions, e.g., cancer and inflammatory diseases. Aim: To investigate new mechanisms for the regulation of pathological IL-6 production. Methods: PBMCs (peripheral blood mononuclear cells) stimulated by cancer serum factors or specific peptides produce interleukin-6 (IL-6). Immunoregulatory albumin neo-structures and peptides wer

Introduction: Tertiary lymphoid structures (TLS) are lymphocyte aggregates resembling secondary lymphoid organs and are pivotal in cancer immunity. The ambiguous morphological definition of TLS makes it challenging to ascertain their clinical impact on patient survival and response to immunotherapy. Objectives: This study aimed to characterize TLS in hematoxylin-eosin tissue sections from lung can

Two cast Mg–Al–Ba–Ca alloys, DieMag633 and DieMag844, are the focus of this study. Their microstructureMicrostructure consists of a eutectic Ca-rich structure, the lamellar Al2Ca, and of a hard, compact and brittle interdendritic Ba-rich phase, the Mg21Al3Ba2 phase. Both phases have a much higher hardness than the α-Mg matrix and strongly influence the crack propagationCrack propagation under quas

Current techniques to determine functional or effective connectivity from magnetoencephalography (MEG) and electroencephalography (EEG) signals typically involve two sequential steps: 1) estimation of the source current distribution from the sensor data, for example, by minimum-norm estimation or beamforming, and 2) fitting a multivariate autoregressive (MVAR) model to estimate the AR coefficients

Quality of supply regulations are today in use in a large number of countries. While these regu-lations are likely to decrease the direct economical consequences from power outages it is less clear to what extent they take into account the societal criticality of consumers. In order to advance knowledge in this area, two different ways of estimating consequences of power outages are here contraste

In February 2007, an epidemic of severe dermatitis from Chinese recliner chairs and sofas started to unfold first in Finland and a few months later in the UK. Some patients reacted in patch tests (PTs) strongly to the material of their furniture, either leather or fabric. There have been hundreds of reports of chair or sofa dermatitis from Finland and the UK, with all cases linked to the same furn

Popular Abstract in Swedish Avhandlingen utgörs av studier av smärtupplevelse i olika befolkningsgrupper. I fokus för analyserna står smärtans totala utbredning. Ett beteendepsykolo-giskt perspektiv har applicerats på psykosociala aspekter av betydelse för att hantera den kroniska smärtan. Alla studier har genomförts på urval av Malmöbefolkningen. Bakgrund. Smärtrelaterad arbetsoförmåga är ett foMusculoskeletal pain-related vocational dysfunction is a major public health problem. The solution is beyond the scope of biomedicine, but the problem could well be analyzed in the complementary, cognitive-behavior psychological frame of reference. In order to better prevent the development of pain-related dysfunction: The sociodemographic milieu of dysfunctional chronic pain patients was examined

Plug-and-Produce (with the meaning that devices can be plugged in without any manual configurations needed) is an attractive paradigm for manufacturing systems, and in particular for Small and Medium Enterprises (SMEs) that do not have the expertise of system integrators but do need to be able to reconfigure their systems by themselves. One approach for loosely (in terms of timing) coupled devices

Rapid development of computer capacity and advances in numerical solution methods for the governing equations of fluid flow and heat transfer have enabled CFD (computational fluid dynamics) methods to gradually become useful tools in research and development, engineering design and analysis of heat transfer equipment. However, turbulence modelling still presents a problem as accurate and reliable

Solar mean magnetic field (SMMF) measurements from the Wilcox SolarObservatory and with SOHO/MDI are analyzed using continuous wavelettransforms, SMMF variability is found at a number of temporal scales.Detected SMMF variations with a 1-2 year period is considered to belinked to long-term variations in the internal rotation of the Sun.Intermediate SMMF oscillations with a period of 80-200 days are

Prototypes of wind turbines of the megawatt class are to be built and tested starting from 2008 at the German offshore wind energy test site in the North Sea. To ensure a high operational reliability of future generations of offshore wind conversion systems (OWEC) with economically acceptable repair and maintenance efforts, comprehensive diagnosis and supervision concepts are required. Automatic m

Sustainability transitions are commonly considered impossible without regime change. Theoretical work on regime change has mainly focused on niches and landscapes and less on change ‘from within’. Empirical analysis helps theorising endogenous regime change. Conceptualising regimes as semi-coherent entities composed of multiple ‘institutional logics’, we analyse the endogenous regime change in Dut

The existing models for the conversion and design of polymer gears are only valid for involute gears. This research was focused on S-gears, a specific type of gear profile which has more favorable contact conditions and greater root thickness when compared to involute gears. S-gears design is currently based on tests, experience, and the use of numerical simulations. Due to the lack of a simple ca

In the spectrum of an emission-line region ejected from the massive star Eta Carinae, called the strontium filament (SrF), forbidden lines from many elements, in particular [Sr II] and [Ti II], are observed. These lines are strong in this specific region and valuable for plasma diagnostics. Forbidden lines are not easily produced in laboratory light sources and the atomic parameters for these line

The Sound Environment Center at Lund University has for over ten years hosted interdisciplinary research on sound environment issues promoting an exchange of ideas between researchers through research projects, interdisciplinary symposiums and publications. The center aims at developing a holistic view to a field that is scientifically fragmented. Ranging from acoustics, noise abatement and sounds

CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up.SETTING: 43 Paediatric Endoc

The problem of adversarial CNN attacks is considered, with an emphasis on attacks that are trivial to perform but difficult to defend. A framework for the study of such attacks is proposed, using real world object manipulations. Unlike most works in the past, this framework supports the design of attacks based on both small and large image perturbations, implemented by camera shake and pose variat

Background: The members of the Task Force on Contact Dermatitis and the Task Force on Occupational Dermatoses of the European Academy of Dermatology and Venereology (EADV), of the European Dermatology Forum (EDF), and the members of the UEMS Section of Dermatology-Venereology (UEMS-EBDV) we want to vindicate the fundamental role that the specialist in Dermatology has in the diagnosis and managemen