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Plug-and-Produce (with the meaning that devices can be plugged in without any manual configurations needed) is an attractive paradigm for manufacturing systems, and in particular for Small and Medium Enterprises (SMEs) that do not have the expertise of system integrators but do need to be able to reconfigure their systems by themselves. One approach for loosely (in terms of timing) coupled devices

Popular Abstract in Swedish Internationalisering av högre utbildning beskrivs i första delen av avhandlingen i ett vidare perspektiv, flera olika forskningstraditioner som berör högre utbildning och internationalisering beskrivs i syfte att utgöra en bakgrund för argument som framhåller ett pedagogiskt och didaktiskt perspektiv som väsentligt i samband med utveckling och konkretisering av en interThe development of higher education in the Western countries involves ideas of internationalisation, included in curricular objectives. Policy-makers stipulate internationalisation ideologies, from a politico-economic perspective, where ideas about flows of various cultural elements are incorporated in visionary idealistic terms. Nevertheless teachers and students and others concerned with higher

Rapid development of computer capacity and advances in numerical solution methods for the governing equations of fluid flow and heat transfer have enabled CFD (computational fluid dynamics) methods to gradually become useful tools in research and development, engineering design and analysis of heat transfer equipment. However, turbulence modelling still presents a problem as accurate and reliable

Popular Abstract in Swedish Vårt immunsystem är uppbyggt runt två typer av celler som har som uppgift att försvaraoss mot infektioner. T lymfocyterna står för det cellmedierade immunförsvaret som är speciellt viktigt för att bekämpa virusinfektioner med B lymfocyterna har som uppgift att producera antikroppar. Antikroppar finns i alla kroppsvätskor och kan interagera med toxiner, virus och bakteriEach immunoglobulin (Ig) V gene segment contains an upstream promoter region. The octamer element and the TATA box are the only elements that are conserved in all Ig promoters. The presence of the octamer element is necessary, but not sufficient to support high levels of transcription. Therefore, the activity of other co-stimulatory elements is required. This investigation has focused on the study

Popular Abstract in Swedish Avhandlingen utreder några av konsekvenserna av de institutionella reformer som genomfördes i Sydafrika under 1990-talet, med särskilt fokus på det nya kommunsystemet, enligt vilket varje kommun är skyldig att stimulera lokal ekonomisk utveckling i samarbete med det lokal näringslivet och andra civilsamhälleliga aktörer. Den syftar även till att utveckla den samhällsvetThis thesis focuses on the consequences of the institutional transformations in South Africa during the 1990s with specific reference to the introduction of a mode of local governance based on the direct participation of private and civic actors in policymaking and implementation. The study also aims to contribute to theory. The approach is that public, private and civic associations are best unde

Solar mean magnetic field (SMMF) measurements from the Wilcox SolarObservatory and with SOHO/MDI are analyzed using continuous wavelettransforms, SMMF variability is found at a number of temporal scales.Detected SMMF variations with a 1-2 year period is considered to belinked to long-term variations in the internal rotation of the Sun.Intermediate SMMF oscillations with a period of 80-200 days are

Humans and most vertebrates have duplex retinae with multiple cone types for colour vision in bright light, and one single rod type for achromatic vision in dim light. Instead of comparing signals from multiple spectral types of photoreceptors, such species use one highly sensitive receptor type thus improving the signal-to-noise ratio at night. However, the nocturnal hawkmoth Deilephila elpenor,

The human antimicrobial peptide cathelicidin LL-37 has, besides its antimicrobial properties, also been shown to regulate apoptosis in a cell type-specific manner. Mechanisms involved in LL-37-regulated apoptotic signaling are not identified. Here, we show that LL-37 reduces the human osteoblast-like MG63 cell number and cell viability in the micromolar concentration range with an IC(50) value of

In the spectrum of an emission-line region ejected from the massive star Eta Carinae, called the strontium filament (SrF), forbidden lines from many elements, in particular [Sr II] and [Ti II], are observed. These lines are strong in this specific region and valuable for plasma diagnostics. Forbidden lines are not easily produced in laboratory light sources and the atomic parameters for these line

Collagen type II (CII) is a cartilage-specific target of pathologic humoral autoimmune responses in rheumatoid arthritis as well as in the collagen-induced arthritis model. The aim of the present study is to investigate the critical amino acid residues conferring CII epitope specificity of the prototypic arthritogenic murine mAb CIIC1. A homology model of the CIIC1 single-chain antibody fragment (

Immunization of mice with type II collagen (CII) leads to collagen-induced arthritis (CIA), a model for rheumatoid arthritis. T cell recognition of CII is believed to be a critical step in CIA development. We have analyzed the T cell determinants on CII and the TCR used for their recognition, using twenty-nine T cell hybridomas derived from C3H.Q and DBA/1 mice immunized with rat CII. All hybridom

We search for signatures of past accretion events in the Milky Way in the recently published catalogue by Nordstrom et al., containing accurate spatial and kinematic information as well as metallicities for 13 240 nearby stars. To optimize our strategy, we use numerical simulations and characterize the properties of the debris from disrupted satellites. We find that stars with a common progenitor

BACKGROUND: Signal transducer and activator of transcription 3 (Stat3) is constitutively active (phosphorylated) in several forms of cancer, including prostate cancer (PCa). Stat3 signaling may be an interesting target for cancer therapy since inhibition of this pathway mediates growth inhibition and apoptosis of these cells. In this study we investigated the in vitro and in vivo effects of the fu

BACKGROUND: Human glandular kallikrein 2 (hK2) and prostate-specific antigen (PSA) are members of an extensive kallikrein family of proteases. Both proteases are secreted as zymogens or proenzymes containing a seven amino acid propeptide that must be proteolytically removed for enzymatic activation. The physiological proteases that activate pro-hK2 and pro-PSA are not known. METHODS: The pro-hK2 p