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Gene editing of CD34+ progenitor cells from single blood donor waste bags to create cultured early erythroid cells for study of blood group knock-outs
Background: Many blood group antigens are carried by red cell surface proteins, thefunctions of which are not yet fully characterized or in some cases completelyunknown. By investigating red cells with naturally-occurring blood group variants,much has been learnt about the underlying molecules. However, interindividualvariation affecting other molecules than the one(s) of interest may confound oro
Probing cosmology via the clustering of critical points
Exclusion zones in the cross-correlations between critical points (peak-void, peak-wall, filament-wall, and filament-void) of the density field define quasi-standard rulers that can be used to constrain dark matter and dark energy cosmological parameters. The average size of the exclusion zone is found to scale linearly with the typical distance between extrema. The latter changes as a function of
Multi-fidelity reduced-order surrogate modelling
High-fidelity numerical simulations of partial differential equations (PDEs) given a restricted computational budget can significantly limit the number of parameter configurations considered and/or time window evaluated. Multi-fidelity surrogate modelling aims to leverage less accurate, lower-fidelity models that are computationally inexpensive in order to enhance predictive accuracy when high-fid
OS03-11 Exposure to PFAS and associated toxicity in workers exposed to hexavalent chromium – a cross-sectional study within the SafeChrom project : Abstracts of the 58th Congress of the European Societies of Toxicology (EUROTOX 2024)
BackgroundThis study aimed to investigate the exposure to perfluoroalkyl substances (PFAS) and cancer-related toxicity in workers in different Swedish industry sectors with exposures to hexavalent chromium (Cr(VI)).MethodsThe study consisted of 111 exposed workers and 72 controls. The exposed workers were performing manufacture/processing of metal products (n=55), working in steel production (n=31
Trace elements and ALAD gene polymorphisms in general population from three uranium legacy sites – A case study in Kyrgyzstan
At three uranium (U) legacy sites in Kyrgyzstan, namely, Kadji Sai, Mailuu-Suu and Sumsar, an initial human bio-monitoring programme was introduced as a complementary activity to environmental impact studies in these areas. The aim was to assess trace element (TE) contents in blood and genetic susceptibility for Pb as one of the contaminants. The programme included the determination of 9 TE in blo
Antibacterial compounds against non-growing and intracellular bacteria
Slow- and non-growing bacterial populations, along with intracellular pathogens, often evade standard antibacterial treatments and are linked to persistent and recurrent infections. This necessitates the development of therapies specifically targeting nonproliferating bacteria. To identify compounds active against non-growing uropathogenic Escherichia coli (UPEC) we performed a drug-repurposing sc
Antibody-guided identification of Achromobacter xylosoxidans protein antigens in cystic fibrosis.
Persistent bacterial airway infection is a hallmark feature of cystic fibrosis (CF). Achromobacter spp. are gram-negative rods that can cause persistent airway infection in people with CF (pwCF), but the knowledge of host immune responses to these bacteria is limited. The aim of this study was to investigate if patients develop antibodies against Achromobacter xylosoxidans, the most common Achromo
2L1 Simultaneous Bilinguals as Heritage Speakers
The chapter is concerned with simultaneous bilinguals (2L1s) assuming that they are a subtype of the heritage speaker (HS). The chapter summarizes major findings with regard to their morpho-syntactic and phonological characteristics, starting with the two competing views on bilingual language development that postulated fused language systems as opposed to autonomous development several decades ag
Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease
Background: High gluten and low dietary fiber in pregnancy intake is associated with an increased risk of celiac disease (CeD) in the child. Early life higher dietary quality is suggested to reduce the subsequent risk of CeD. Objectives: The aim was to investigate associations of pregnancy dietary quality and diversity with child risk of CeD. Methods: In The Norwegian Mother, Father and Child Coho
Stability and Change in Portuguese Adolescents’ Affective Profiles over a 2-Year and a 6-Year Period
Background: The affective profiles model, operationalized as the combination of individuals’ high/low positive/negative affective experience, is a well-established method for providing insights into adolescents’ affective functioning and self-regulation: self-fulfilling (high positive affect, low negative affect), high affective (high positive affect, high negative affect), low affective (low posi
Towards a New System to Support Decision-Making for Improved Housing Accessibility - Co-Creation of Knowledge and Interfaces for Transboundary Planning, Strategies, Approaches and Communications
NUMERICAL ANALYSIS OF AN AXIAL HIGH PRESSURE PARTIAL ADMISSION TURBINE
The transformation of the energy systems will call for new turbomachinery designs for harvesting low-grade heat. The word “low-grade” has many definitions and ranges from levels where steam is the preferred selection to very low grades where specially adopted ORC technology is used. In this work, turbomachinery for cascading the steam cycle with a very low-temperature ORC technology is studied. Th
CO2 emission impacts of introducing heavier and longer trucks in the Swedish transport system
In recent years the possibility to increase maximum length and weight of heavy goods vehicles to allow for High Capacity Vehicles (HCVs) has been debated in Sweden. Proposals to increase maximum weight to 74 tonnes, and length to 34m have caused controversy. Key arguments among proponents are that HCVs will bring about benefits, such as: increasing energy efficiency and decreasing CO 2 emissions,
Antigenic and biochemical characteristics of Mobiluncus mulieris and Mobiluncus curtisii
Twenty-four strains of Mobiluncus mulieris and 27 strains of Mobiluncus curtisii were tested with respect to 6 different biochemical characteristics: arginin-decarboxylase activity, beta-galactosidase activity, synergistic hemolysis with Staphylococcus aureus, hydrolysis of hippurate, migration through soft agar and reduction of nitrate. Antigens of the same strains, prepared by ultrasonication, w
Monitoring and Evaluation as a Way to Complete and to Implement a Policy : The Case of Brazilian National Innovation Policy
The present National Innovation Policy (henceforth called PNI) was instituted in Brazil by Decree No. 10.537, of October 28, 2020, within the federal public administration. The policy's objective is to guide, coordinate and articulate strategies, programs, and actions across several public entities to foster innovation in the productive sector. Thus, it aims to increase the productivity and compet
The Sixth Data Release of the Radial Velocity Experiment (RAVE). II. Stellar Atmospheric Parameters, Chemical Abundances, and Distances
We present part 2 of the sixth and final Data Release (DR6) of the Radial Velocity Experiment (RAVE), a magnitude-limited (9 < I < 12) spectroscopic survey of Galactic stars randomly selected in Earth's southern hemisphere. The RAVE medium-resolution spectra (R ∼ 7500) cover the Ca triplet region (8410-8795 Å) and span the complete time frame from the start of RAVE observations on 2003 April 12 to
Fast-track programs in total hip and knee replacement at swedish hospitals—influence on 2-year risk of revision and mortality
Purpose: We aimed to study the influence of fast-track care programs in total hip and total knee replacements (THR and TKR) at Swedish hospitals on the risk of revision and mortality within 2 years after the operation. Methods: Data were collected from the Swedish Hip and Knee Arthroplasty Registers (SHAR and SKAR), including 67,913 THR and 59,268 TKR operations from 2011 to 2015 on patients with
Cell-cycle kinetics of proliferating mouse B lymphocytes in vitro
Resting mouse B lymphocytes were stimulated in vitro with lipopolysaccharide, Sepharose-coupled anti-kappa antibodies or a combination of the two. B lymphocytes stimulated with anti-kappa entered the cell-cycle with more rapid kinetics and at a higher frequency than did the corresponding cell population stimulated with lipopolysaccharide. Using cell cycle analysis after DNA staining combined with
