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UNLABELLED: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of doubl
The adsorption of soft microgels at interfaces is a key phenomenon in numerous applications, including emulsification, interfacial stabilization, and responsive coatings. In this work, we employ a combination of in situ atomic force microscopy and numerical simulations to systematically investigate the structural behavior of individual microgels at liquid-liquid and solid-liquid interfaces. By dir
The end-Permian mass extinction greatly affected the sedimentary record, but the sedimentary response was not limited to the Permian-Triassic boundary interval. This transformation extended to sedimentation that spanned the entire Early Triassic. Calcimicrobialites play an important role throughout this time interval, and at least four main events of anomalous carbonate deposition can be shown. A
Context. Studies of the internal kinematics of the LMC have provided a detailed view of its structure, largely thanks to the exquisite proper motion data supplied by the Gaia mission. However, line-of-sight (LoS) velocities, the third component of the stellar motion, are only available for a small subset of the current Gaia data, thus limiting studies of the kinematics perpendicular to the LMC dis
The robotic future is nearly here, and East Asia stands at the forefront of this shift. East Asian firms innovating in this sector are backed in various ways by governments committed to competing for leadership in robotics. This field promises to unleash heightened productivity and precision in manufacturing, while the opportunities in services are also enormous. The expanded installation of robot
Haploblocks are regions of the genome that coalesce to an ancestor as a single unit. Differentiated haplotypes in these regions can result from the accumulation of mutational differences in low-recombination chromosomal regions, especially when selective sweeps occur within geographically structured populations. We introduce a method to identify large well-differentiated haploblock regions (LHBRs)
Product development faces increasing challenges in today’s fast-evolving environment. Agile has emerged as a promising approach to navigate and succeed under such conditions. Grounded in the values and principles of the Manifesto for Agile Software Development, practitioners have designed agile frameworks and practices that have demonstrated significant benefits in software development. Motivated
The rise in milk adulteration and contamination, fraud incidents and improper handling necessitates effective traceability systems in the Indian dairy industry. Thus, this review investigates current trends, associated challenges, traceability and its fundamental applications to address food safety and quality issues. The paper covers the evolution of milk adulteration and contamination detection
Objectives: Mammographically spiculated breast cancer is frequently less aggressive than cancers with alternative appearances. This study aims to investigate whether the degree of spiculations relative to the tumor mass on mammography, termed the spic mass ratio (SMR), is associated with breast cancer characteristics and survival. Materials and methods: This retrospective exploratory single-center
Terrestrial ecosystems regulate climate by absorbing about one-third of anthropogenic CO2 emissions. Monitoring carbon, water, and energy fluxes is essential for understanding ecosystem responses to climate change. However, existing flux datasets lack sufficient spatial resolution and consistency needed for fragmented landscapes like UK agricultural areas. This study presents the Unified FLUXes (U
Sahej Rahal’s 2022 exhibition ANCESTORS presented findings from an alleged archaeological site to narrate an alien temporality inside the confines of the history museum. We reflect on how the exhibition demonstrates that encounters with appropriately narrated objects constitute a sort of “temporal heist,” forcing its observers to reconsider their present through a new temporality. By articulating
The rapid expansion of cross-border telework has exposed structural frictions between the European Union’s (EU’s) coordination of social security and the international allocation of taxing rights. This article examines how the simultaneous application of Regulation No. 883/2004 and double tax conventions affects the financing of social security systems. It first situates Member States’ heterogeneo
This editorial introduces the Special Section on 'The Borders Within: Socio-Economic Rights and Non-discrimination in EU Law' whose purpose is to provide a comprehensive and non-fragmented understanding of socio-economic rights, the right to non-discrimination and their meaning for welfare in EU Member States. Under EU law the boundaries between national socio-economic policies and the enjoyment o
Research on the rhythmic communication (RC) of nonhuman animals is undergoing a period of great effervescence and expansion. Here, we synthesize this rapidly growing literature with the aim of mapping RC forms and usage contexts in an unprecedented diversity of taxa, spanning insects, fish, frogs, birds and mammals. We see this as a first large-scale effort toward charting the functional and struc
Health is multifaceted, with divergent interpretations in diverse cultures and groups of individuals. The ways individuals understand health might aid in developing future interventions. There is scant knowledge on how adolescents with depression conceptualise health. A descriptive qualitative design with a phenomenographic approach was used to describe the different ways adolescents with depressi
