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Background: Head computed tomography (CT) is a guideline recommended method to predict functional outcome after cardiac arrest (CA), but standardized criteria for evaluation are lacking. To date, no prospective trial has systematically validated methods for diagnosing hypoxic-ischaemic encephalopathy (HIE) on CT after CA. We present a protocol for validation of pre-specified radiological criteria

AIMS: Diabetic peripheral neuropathy (DPN) is a common and severe complication to type 2 diabetes (T2D). The pathogenesis of DPN is not fully known, but several pathways and gene polymorphisms contributing to DPN are described. DPN can be studied using nerve biopsies, but studies on the proteome of the nerve itself, and its surrounding tissue as a whole, are lacking. Studies on the posterior inter

BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled

Obesity associates with reduced life expectancy, type 2 diabetes, hypertension and cardiovascular disease, and is characterized by chronic inflammation. Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein, dead cells and some microorganisms. Antibodies against PC (anti-PC) have anti-inflammatory properties. Here, we explored the role of anti-PC in hospitalized versus non-hospi

BACKGROUND: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-te

Background/Aim: Signs of hypoxic ischaemic encephalopathy (HIE) on head computed tomography (CT) predicts poor neurological outcome after cardiac arrest. We explore whether levels of brain injury markers in blood could predict the likelihood of HIE on CT. Methods: Retrospective analysis of CT performed at 24–168 h post cardiac arrest on clinical indication within the Target Temperature Management

OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) acts at the crossroad between immunity and cancer, being an attractive therapeutic target in these areas. IGF1R is broadly expressed by antigen-presenting cells (APC). Using mice immunised with the methylated albumin from bovine serum (BSA-immunised mice) and human CD14 + APCs, we investigated the role that IGF1R plays during adaptive immune

We report the discovery of a third planet transiting the star TOI-1260, previously known to host two transiting sub-Neptune planets with orbital periods of 3.127 and 7.493 d, respectively. The nature of the third transiting planet with a 16.6-d orbit is supported by ground-based follow-up observations, including time-series photometry, high-angular resolution images, spectroscopy, and archival ima

BACKGROUND: A significant proportion of patients with ST-segment– elevation myocardial infarction (MI) have no standard modifiable cardiovascular risk factors (SMuRFs) and have unexpected worse 30-day outcomes compared with those with SMuRFs. The aim of this article is to examine outcomes of patients with non–ST- segment– elevation MI in the absence of SMuRFs. METHODS AND RESULTS: Presenting featu

CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated. OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the H

Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103 - cDC2s and LysoDCs in the subepithelia

A housewife of many trades: applying history of knowledge to the rationalization of the home in 1946–1956. After World War II, Swedish women were expected to return to their work at home, due to a shortfall of work for men. However, to make housework more attractive for women, its status needed to increase. One way to make housework more appealing for women was to rationalize the home and therefo

Psykosociala faktorers samband med PMS undersöktes genom en webbaserad enkätundersökning som besvarades av 1320 svensktalande kvinnor och transpersoner med aktiv menscykel. Studien visade samband mellan höga nivåer av PMS och att bo tillsammans med barn eller partner samt att ha en mindre stöttande partner och låg relationstillfredställelse. Personer med en låg utbildningsnivå, egna erfarenheter aThe association between PMS and psychosocial factors was studied using the responses of 1320 women and transgender people with an active menstrual cycle to a Swedish web-based survey. Living with children or a romantic partner was associated with higher levels of PMS, in addition to low relational satisfaction and a less supportive partner. Premenstrual Coping, Perfectionism and Silencing the Self

Populärvetenskaplig sammanfattning: Klimatväxlingarna under sista istiden har alltid varit en debattfråga. Denna istids kallaste period inträffade för cirka 20.000 år sedan och benämns "istidsmaximum". Då var havsytan hundratjugo meter lägre än idag och det mesta vattnet var bundet i inlandsisarna. Klimatväxlingar försöker dagens kvartärgeologer att fastställa med en så bra tidsutlösningHigh-resolution analyses of sediments from two sites in Blekinge, south-eastern Sweden (the former Lake Togölen and Lake Bredsjön), were evaluated in order to establish the pollenstratigraphical position of the second and final drainage of the Baltic Ice Lake in relation to the Younger Dryas-Preboreal pollen zone transition. Remanent magnetisation and magnetic susceptibility were used to correlate

The discourse on beauty has primarily been focused on the white gaze to prescribe its normative standards. The white gaze conceptualizes the way in which beauty is dwelled on within society: the foisting of Caucasian-looking beauty canons on black women, and the veneration of whiteness as superior. Black bodies are vanguards, either being desired or erased. In literature, the expression “white gaz

Denna uppsats bygger på forskning inom den komplexa juridiska situationen bakom EU’s externa agerande och konflikten mellan externa och interna juridiska spörsmål inom områden med delad kompetens inom Unionen. EU’s lagstiftning, genom sin egen struktur, har en unik position inom hierarkin för rättskällor. Av de i uppsatsen presenterade rättsfallen och dokumentationen i övrigt kan man utläsa att deThis thesis is based on research into the area of the complex legal situation behind EU’s external affairs with the conflict between external and internal legal matters in regards to the area of shared competences within the Union. EU legislation, by its own structure, has a unique position in the hierarchy of laws. As can be seen by case law and documentation presented here it also contains its o

To generate the required antiproton beam intensity for the FAIR PANDA experiment, a dedicated proton LINAC (pLINAC) for the FAIR accelerator chain is being constructed. Klystron modulators are power converters within the high-power RF system of the pLINAC. Here, seven modulator systems with a nominal pulse power amplitude of 115 kV / 54 A, an effective pulse width of 360 µs and a pulse repetition

Electrostatic energy plays a pivotal role in the minimization of the free energy of self-assembling oppositely charged ions. This is a fundamental principle that guides the formation of aggregates and the separation of phases characterized by a stoichiometric balance between the opposite charges. However, this study unveils the self-assembly of catanionic nanotubes from a mixture of oppositely cha

Background: In Western settings, community-acquired pneumonia (CAP) due to Gram-negative bacilli (GNB) is relatively rare. Previous studies from Asia, however, indicate a higher prevalence of GNB in CAP, but data, particularly from Southeast Asia, are limited. Methods: This is a prospective observational study of 1451 patients ≥15 y of age with CAP from two hospitals in Cambodia between 2007 and 2