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Ultra-f aint dw arf galaxies (UFDs) are commonly found in close proximity to the Milky Way and other massive spiral galaxies. As such, their projected stellar ellipticity and extended light distributions are often thought to owe to tidal forces. In this paper, we study the projected stellar ellipticities and faint stellar outskirts of tidally isolated ultra-faints drawn from the 'Engineering Dwarf

Corded Ware is one of the main archaeological phenomena of the third millennium before the common era (BCE), with a wide geographic spread across much of central and northeastern Europe, from Denmark, the Rhineland, and Switzerland in the west to the Baltic and Western Russia in the east, and broadly restricted to the temperate, continental zones north of the Alps, the Carpathians, and the steppe/

Adipose-derived lipid droplets (LDs) are rich in triacylglycerols (TAGs), which regulate essential cellular processes, such as energy storage. Although TAG accumulation and LD expansion in adipocytes occur during obesity, how LDs dynamically package TAGs in response to excessive nutrients remains elusive. Here, we found that LD lipidomes display a remarkable increase in TAG acyl chain saturation u

Existing datasets for autonomous driving (AD) often lack diversity and long-range capabilities, focusing instead on 360° perception and temporal reasoning. To address this gap, we introduce Zenseact Open Dataset (ZOD), a large- scale and diverse multimodal dataset collected over two years in various European countries, covering an area 9×that of existing datasets. ZOD boasts the highest range and

Höftprotesoperationer har blivit en mycket vanlig operation med generellt goda resultat. Allt fler och allt yngre patienter opereras vilket ställer högre krav på att höftprotesen fungerar bättre och håller längre så att en omoperation kan undvikas. En av de vanligaste orsakerna till att höftproteser behöver omopereras är effekter av cupslitage, det vill säga slitage av plasten som utgör slitytan i

In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not car

The formation of amyloid fibrils by the intrinsically disordered protein alpha-synuclein is a hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of aggregation of this protein we have used in vitro aggregation assays in the presence of preformed seed fibrils to determine the molecular rate constant of fibril elongation under a range of different conditions. We sh

A wide range of factors shapes irrigation institutions and collective action with regard to irrigation. They include the distribution of land across irrigation command areas and across classes, land tenure systems, access to new technology such as bore wells, the availability and cost of electricity and other energy sources for lifting groundwater, and, above all, state policies related to irrigat

Objectives The study sought to evaluate the relationship between procedural volume and outcomes with radial and femoral approach. Background RIVAL (RadIal Vs. femorAL) was a randomized trial of radial versus femoral access for coronary angiography/intervention (N = 7,021),which overall did not show a difference in primary outcome of death, myocardial infarction, stroke, or non-coronary artery bypa

Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the development of inhibitors that selectively target PIP5K1α have not been reported. In the present study we repor

This statement provides a concise list of diagnostic terms for ECG interpretation that can be shared by students, teachers, and readers of electrocardiography. This effort was motivated by the existence of multiple automated diagnostic code sets containing imprecise and overlapping terms. An intended outcome of this statement list is greater uniformity of ECG diagnosis and a resultant improvement

In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in act

We have investigated terahertz (THz) emission due to dynamical electron transport in wide miniband GaAs/Al0.3Ga0.7As superlattices. By noting that the time-domain THz emission spectroscopy contains the information on the step response of the electron system to the bias electric field, the obtained THz spectra were compared with the high-frequency conductivities predicted for miniband transport. Ex

Popular Abstract in Swedish En annan modernism? Form, innehåll och betydelse av ny bostadsarkitektur i Hanoi.The study deals with the issue of how to understand and assess modern architecture in a non-Western context. Is there a non-Western modern architecture in its own right and with meanings connected to the local context or is it mere copy of Western modern architecture? At the primary level the study discusses the meanings and directions of contemporary architecture in a modernising society such as

Many patients with asthma or chronic obstructive pulmonary disease (COPD) routinely receive a combination of an inhaled bronchodilator and anti-inflammatory glucocorticosteroid, but those with severe disease often respond poorly to these classes of drug. We assessed the efficacy and safety of a novel inhaled dual phosphodiesterase 3 (PDE3) and PDE4 inhibitor, RPL554 for its ability to act as a bro

A major barrier for cancer immunotherapy is the presence of suppressive cell populations in patients with cancer, such as myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM), which contribute to the immunosuppressive microenvironment that promotes tumor growth and metastasis. Tasquinimod is a novel antitumor agent that is currently at an advanced stage of clinical develo