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For decades, in vitro expansion of transplantable hematopoietic stem cells (HSCs) has been an elusive goal. Here, we demonstrate that multipotent adult progenitor cells (MAPCs), isolated from green fluorescent protein (GFP)-transgenic mice and expanded in vitro for >40-80 population doublings, are capable of multilineage hematopoietic engraftment of immunodeficient mice. Among MAPC-derived GFP+CD4

The World Health Organization (WHO) tuberculosis (TB) symptom screening instrument (WHO-TB) can identify human immunodeficiency virus (HIV)-infected individuals at low risk of tuberculosis (TB); however, many patients report WHO-TB symptoms and require further TB investigations. We hypothesized that further clinical scoring could classify subjects with a positive WHO-TB screening result (WHO-TB(+)

Galectins are versatile glycan-binding proteins involved in immunomodulation. Evidence suggests that galectins can control the immunoregulatory function of cytokines and chemokines through direct binding. Here, we report on an inverse mechanism in which chemokines control the immunomodulatory functions of galectins. We show the existence of several specific galectin-chemokine binding pairs, includ

Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in m

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we

Purpose The purpose is to explore if a potential gap exists between information sharing as recommended in academic literature and the information actually shared among companies and their supply chain partners. Design/methodology/approach The paper is based on an extensive literature review to structure the terminology for information sharing in supply chains and an in-depth interview study to ex

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with a polybacterial dysbiosis devoid of a known pathogen. Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci are detected in the epidermis, surrounded by IgA deposits

Objective: Previously proposed “synchronous EEG patterns” predict poor outcome within 24 h after cardiac arrest (CA). We investigate the prognostic performance of these early EEG predictors in addition to the late EEG predictors (>24 h) recommended in the European post-resuscitation guidelines. Methods: Observational substudy of the TTM2-trial including consecutive comatose resuscitated patients.

Syftet med uppsatsen är att få ökad kunskap om studenters attityder till försäljning av sexuella tjänster. En enkätundersökning på Lunds universitet har genomförts under våren 2018. Uppsatsen testar hypotesen att kontexten som dessa studenter växt upp i med rådande sexköpslagstiftning utgör en starkare påverkan än trenden med en mer liberal inställning till försäljning av sexuella tjänster. Det teThis essay’s purpose is to gain increased knowledge about students’ attitudes towards the sale of sexual services. An online survey was conducted at Lund’s university during the spring of 2018. The essay tests the hypothesis that the context where these students grew up, with the Swedish sex purchase legislation, constitutes a stronger influence than the trend of a more liberal attitude towards th

By combining a legal doctrinal study and an empirical interview study, this thesis examines the implementation of the right to access to justice under article 13 of the Convention on the Rights of Persons with Disabilities for persons who due to post-traumatic stress syndrome have difficulties accounting for their stories in asylum proceedings. The starting point is that persons with PTSD likely w

The aim of this master’s thesis is to investigate the discursive networks and production contexts of the rare and insular phenomena of Swedish experimental features. As a point of departure, the tentative and limited filmography of Swedish artist Öyvind Fahlström is expanded upon, as the thesis present a unique case study on his first and only feature film Du gamla, Du fria (“Provocation”, 1972).

I och med Hu Jintaos och Wen Jiabaos tillträde till makten har den kinesiska regeringens fokus kommit att flyttas från ren ekonomisk utveckling till att i högre grad än tidigare fokusera på att minska klyftorna mellan stad och landsbygd. Denna uppsats undersöker några av de problem som centralregeringen ser på landsbygden idag, samt några av de lösningar som presenterats. I undersökningen av situaSince Hu Jintao and Wen Jiabao took office the focus of the Chinese government has been less on pure economic development than before and more on developing the countryside. This paper investigates some of the problems the central government sees in the countryside as well as some of their solutions to those problems. The book The Grain People: Will China’s Villages Disappear? (Liangmin－Zhongguo n

This thesis addresses the correlation between creditor protection and thecross-border seat transfer of companies in the light of the case law of the European Court of Justice concerning the freedom of establishment of undertakings. After the restrictive outcome of Daily Mail, the judgment of the European Court of Justice in Centros took the legal community by surprise. The following cases of Übers

Spectroscopic surveys of the Milky Way's stars have revealed spatial, chemical, and kinematical structures that encode its history. In this work, we study their origins using a cosmological zoom simulation, VINTERGATAN, of a MilkyWay-mass disc galaxy. We find that in connection to the last major merger at z ∼ 1.5, cosmological accretion leads to the rapid formation of an outer, metal-poor, low-[α/

fncel-14-00146.pdf REVIEW published: 29 May 2020 doi: 10.3389/fncel.2020.00146 Edited by: Sofia Grade, Institute of Molecular Biotechnology (OeAW), Austria Reviewed by: Daniel Tornero, University of Barcelona, Spain Afsaneh Gaillard, University of Poitiers, France *Correspondence: Anders Björklund anders.bjorklund@med.lu.se Specialty section: This article was submitted to Cellular Neuropathology,

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_frontiers.pdf - 2026-05-10

Hepatic fibrosis can result as a pathological response to nonalcoholic steatohepatitis (NASH). Cirrhosis, the late stage of fibrosis, has been linked to poor survival and an increased risk of developing hepatocellular carcinoma, with limited treatment options available. Therefore, there is an unmet need for novel effective antifibrotic compounds. Cyclophilins are peptidyl-prolyl cis-trans isomeras

We conducted two experiments where subjects rated images of a robot head with different eye colors and light intensities on how well they communicate emotions like anger, enjoyment, and surprise, as well as personality traits like friendliness, intelligence, and level of trust. Results indicate e.g. that green and turquoise eye colors were more associated with agreeable personality traits. We foun

The human plasma protein alpha1-microglobulin (alpha1m) was found to inhibit the antigen-induced interleukin-2 (IL-2) production of two different mouse T-helper cell hybridomas. Alpha1m isolated from human plasma and recombinant alpha1m isolated from baculovirus-infected insect cell cultures had similar inhibitory effects. Flow cytometric analysis showed a binding of plasma and recombinant alpha1m

False lumen management of chronic aortic dissections has evolved during the past decade. Thoracic endovascular aortic repair (TEVAR) continues to be the mainstay of endovascular dissection treatment and relies on the adequate sealing of the proximal entry tear. However, TEVAR alone often fails to achieve aortic remodeling due to persistent distal retrograde perfusion of the false lumen with contin