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Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global act

Background Potassium disturbances per se increase the risk of ventricular fibrillation (VF). Whether potassium disturbances in the acute phase of ST-segment-elevation myocardial infarction (STEMI) are associated with VF before primary percutaneous coronary intervention (PPCI) is uncertain. Methods and Results All consecutive STEMI patients were identified in the Eastern Danish Heart Registry from

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this context, established tumor cell lines can be very informative, as they may be used for in-depth molecular analyses and improvement of treatment strate

Background Some evidence suggests that chronic kidney disease is a risk factor for lower-extremity peripheral artery disease. We aimed to quantify the independent and joint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eGFR] and albuminuria) with the incidence of peripheral artery disease. Methods In this collaborative meta-analysis of international

Complement is crucial to the immune response, but dysregulation of the system causes inflammatory disease. Complement is activated by three pathways: classical, lectin, and alternative. The classical and lectin pathways are initiated by the C1r/C1s (classical) and MASP-1/MASP-2 (lectin) proteases. Given the role of complement in disease, there is a requirement for inhibitors to control the initiat

Use of clay brick masonry in façades is often motivated by its aesthetic values and durability. Yet, mortar joints exposed to climate agents erode over time, expected to cause elevated moisture content and water absorption. Thus, it is often recommended that 40- to 50-year-old facades should be repointed – a measure which is intrusive and costly. Decision is in many cases taken without a clear evi

We introduce the 'Engineering Dwarfs at Galaxy Formation's Edge' (EDGE) project to study the cosmological formation and evolution of the smallest galaxies in the Universe. In this first paper, we explore the effects of resolution and sub-grid physics on a single low-mass halo (Mhalo = 109M⊙), simulated to redshift z = 0 at amass and spatial resolution of ∼ 20 M⊙ and ∼3 pc. We consider different st

Phage display technology is a common approach for discovery of therapeutic antibodies. Drug candidates are typically isolated in two steps: First, a pool of antibodies is enriched through consecutive rounds of selection on a target antigen, and then individual clones are characterized in a screening procedure. When whole cells are used as targets, as in phenotypic discovery, the output phage pool

Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surface of migrating cells. We insert GFP into the rigid, ligand-binding head of the integrin, model with

Currently, many research studies are exploring opportunities for the use of novel fuels and of their blends with conventional, i.e. petroleum-based fuels. To pave the way for their acceptance and implementation in the existing energy market, a comprehensive knowledge about their combustion properties is inevitable, among others. Within this context, alcohols, with butanol in particular, are consid

The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recogni

We present a new type of nanometer-scale semiconductor nonlinear device, called self-switching device (SSD). The device was realized by simply etching insulating grooves into a semiconductor, between which a narrow channel with a broken symmetry was formed. Because of the asymmetry in the channel boundary, an applied voltage V not only changes the potential profile along the channel direction, but

Lund University has offered the Sida-financed International Training Programmeon Child Rights, Classroom and School Management since 2003. Theprogramme targets those in a position from which they can initiate processesof change in the education sector in their countries. During the programmeall participating teams initiate a change project in their respective countriesaiming at the realization of

Background A 1-h algorithm based on high-sensitivity cardiac troponin T (hs-cTnT) testing at presentation and again 1 h thereafter has been shown to accurately rule out acute myocardial infarction. Objectives The goal of the study was to evaluate the diagnostic accuracy of the 1-h algorithm when supplemented with patient history and an electrocardiogram (ECG) (the extended algorithm) for predicti

Ley crops can be grown to provide a substrate for biogas vehicle-fuel production on a range of soils including marginal land. According to EU regulations, such biofuel currently has to achieve an emission reduction of 35%, but tightened goals of 50 and 60% will come into effect as early as 2017. In two field trials (one on marginal soil, one on productive soil) ley crop mixtures were tested and th

This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal

It is well known that the origin of one type of spurious solutions in multiband k(.)p theory is the failure to restrict the Fourier coefficients of the envelope functions to the first Brillouin zone. Often, the set of differential equations obtained is supplemented with interfacial boundary conditions derived by integrating the differential equations across the interface; however, this leads to a