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Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the development of inhibitors that selectively target PIP5K1α have not been reported. In the present study we repor

Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exace

Chlamydia trachomatis is a major cause of bacterial sexually transmitted infections worldwide. In 2006, a new variant of C. trachomatis (nvCT), carrying a 377 bp deletion within the plasmid, was reported in Sweden. This deletion included the targets used by the commercial diagnostic systems from Roche and Abbott. The nvCT is clonal (serovar/genovar E) and it spread rapidly in Sweden, undiagnosed b

The aging of the population is a worldwide trend, especially in Western countries. The increased number of people living past 65 years is also a trend for polypharmacy (the multiple use of medication) among elderly people. In terms of market orientation, the pharmaceutical industry is well-developed, but the same cannot be said in terms of design orientation. Previous studies indicate that packagi

In patients with chronic obstructive pulmonary disease (COPD), Moraxella catarrhalis infection of the lower airways is associated with chronic colonization and inflammation during stable disease and acute exacerbations. Chronic smoke exposure induces chronic inflammation and impairs mucociliary clearance, thus contributing to bacterial colonization of the lower airways in COPD patients. The human-

Galectin-3 (Gal-3), an endogenous lectin, exhibits ro- and anti-inflammatory effects in various disease conditions. In order to explore the role of Gal-3 in KT-cell-dependent pathology, we induced hepatitis in C57BL/6WT and al-3-deficient mice by using specific ligand for KT cells: alpha-galactosylceramide, glycolipid Ag presented by CD1d. The injection of alpha-galactosylceramide significantly en

The formation of amyloid fibrils by the intrinsically disordered protein alpha-synuclein is a hallmark of Parkinson disease. To characterize the microscopic steps in the mechanism of aggregation of this protein we have used in vitro aggregation assays in the presence of preformed seed fibrils to determine the molecular rate constant of fibril elongation under a range of different conditions. We sh

A wide range of factors shapes irrigation institutions and collective action with regard to irrigation. They include the distribution of land across irrigation command areas and across classes, land tenure systems, access to new technology such as bore wells, the availability and cost of electricity and other energy sources for lifting groundwater, and, above all, state policies related to irrigat

Work-related respiratory symptoms, including dyspnoea, cough, fever, tiredness and malaise, were recorded in two customs officers employed in 2 depositories of confiscated cigarettes, of which one showed signs of dampness. Microbiological sampling of the air and the cigarettes stored in a damp depository revealed the presence of potentially pathogenic fungi and bacteria and the biochemical markers

This statement provides a concise list of diagnostic terms for ECG interpretation that can be shared by students, teachers, and readers of electrocardiography. This effort was motivated by the existence of multiple automated diagnostic code sets containing imprecise and overlapping terms. An intended outcome of this statement list is greater uniformity of ECG diagnosis and a resultant improvement

In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in act

We have investigated terahertz (THz) emission due to dynamical electron transport in wide miniband GaAs/Al0.3Ga0.7As superlattices. By noting that the time-domain THz emission spectroscopy contains the information on the step response of the electron system to the bias electric field, the obtained THz spectra were compared with the high-frequency conductivities predicted for miniband transport. Ex

Popular Abstract in Swedish En annan modernism? Form, innehåll och betydelse av ny bostadsarkitektur i Hanoi.The study deals with the issue of how to understand and assess modern architecture in a non-Western context. Is there a non-Western modern architecture in its own right and with meanings connected to the local context or is it mere copy of Western modern architecture? At the primary level the study discusses the meanings and directions of contemporary architecture in a modernising society such as

Annamirl and the Stove of Delight. With reference to "folk art" and "folk art" research in Europe.

Hematologic malignancies are characterized by fusion genes of biological/clinical importance. Immortalized cell lines with such aberrations are today widely used to model different aspects of leukemogenesis. Using cDNA microarrays, we determined the gene expression profiles of 40 cell lines as well as of primary leukemias harboring 11q23/MLL rearrangements, t(1;19)[TCF3/PBX1], t(12;21)[ETV6/RUNX1]

Plats och tid Saco-rådet Umeå kommun ÅRSMÖTESPROTOKOLL 2017-03-22 Plats och tid Onsdag den 22 mars 2017, Fackenshus, Vasagatan kl 17.00 – 19.15. Närvarande Saco- medlemmar Per-Olov Backlund SSR Birgitta Larsson LR Lena Svedjehed Psykologförbundet Anne Christine Lejon Jusek Emma Lundström Jusek Carina L Heimersson Jusek Mats Boman Sv Skolledarförbund Eva Hietala Naturvetarna Annika Winning DIK Kari

https://www.saco.se/globalassets/lokala-akademikerforeningar/kommun-och-region/umea-kommun/dokument/protokoll-2017.doc - 2026-05-08

PowerPoint-presentation www.saco-s.se Terms and conditions as a postdoc Rights and obligations Sacoförbunden för dig som är akademiker i statenSacoförbunden för dig som är akademiker i staten The local Saco-S union at SLU •Turn to Saco-S at SLU if you are a member and have any questions about your situation at SLU •Local web page •Central web page www.saco-s.se http://www.saco-s.se/ Contents • Dif

https://www.saco.se/globalassets/lokala-akademikerforeningar/statlig/slu/dokument/postdok-15-feb-2024.pdf - 2026-05-08

https://www.lth.se/fileadmin/cee/genombrottet/Kursplan__leda_och_utveckla_kurser_paa_LTH_GB_A12_2023.pdf - 2026-04-24