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Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer

More than three-quarters of primary breast cancers are positive for estrogen receptor alpha (ER; encoded by the gene ESR1), the most important factor for directing anti-estrogenic endocrine therapy (ET). Recently, mutations in ESR1 were identified as acquired mechanisms of resistance to ET, found in 12% to 55% of metastatic breast cancers treated previously with ET. We analyzed 3217 population-bas

European project to develop a UV/VUV free-electron laser facility on the ELETTRA storage ring

Sincrotrone Trieste, collaborating with various institutions, has recently begun a 3-year project to develop a UV/VUV free-electron laser on the ELETTRA storage ring. The main features and novel technical aspects of the project are described, including the design of the optical cavity and undulator, the electron beam characteristics and a first assessment of the predicted laser performance. Prelim

Noninvasive Staging of Lymph Node Status in Breast Cancer Using Machine Learning : External Validation and Further Model Development

Background: Most patients diagnosed with breast cancer present with a node-negative disease. Sentinel lymph node biopsy (SLNB) is routinely used for axillary staging, leaving patients with healthy axillary lymph nodes without therapeutic effects but at risk of morbidities from the intervention. Numerous studies have developed nodal status prediction models for noninvasive axillary staging using po

An employeeship model and its relation to psychological climate : A study of congruence in the behavior of leaders and followers

Popular Abstract in Swedish Denna avhandling behandlar organisatoriska aspekter som organisationsklimat, psykologiskt klimat samt medarbetarskap utifrån ledarskapsbeteende, arbetskamratsbeteende och interaktivt ledare-följarebeteende. Den sistnämnda faktorn handlar både om ledarens och följarens (medarbetarens, arbetskamratens) beteende och om dessa är samstämmiga (kongruenta) eller skilda. AvhandThis doctoral dissertation was driven by an inspiration to study how employees behave toward each other from an interactive perspective where all members of an organization are considered active contributors. Employeeship holds this perspective and acknowledges the importance of productive relationships. The objective of this dissertation is to contribute to the conceptual and methodological devel

Diabetes mellitus and risk of prostate cancer - A focus on shared risk factors and survivor bias

Popular Abstract in Swedish Prostatacancer är den vanligaste formen av cancer hos män i Sverige och ungefär 10 000 män diagnosticeras årligen. Prostatacancer tros orsakas av en kombination av ärftliga faktorer och miljö-/livsstilsfaktorer. De enda väletablerade riskfaktorerna för prostatacancer är ålder, etnicitet och ärftlighet inom familjer. För att kunna arbeta med förebyggande av denna sjukdomProstate cancer (PCa) is a heterogenous disease including very aggressive lethal tumors to incidentally discovered clinically insignificant tumors. Age, ethnicity, and family history are the only established risk factors. Type 2 diabetes mellitus (T2D) has been found to associate with increased overall cancer risk but with lower risk of specifically PCa. T2D is initially associated with increased

Male moth behaviour and perception in pheromone plumes

Popular Abstract in Swedish Nattfjärilshannars beteenden och doftupplevelser i feromonplymer Denna skrift avhandlar mekanismerna bakom så kallad förvirringsbekämpning av skadegörande nattfjärilar med hjälp av deras sexualferomon. Nattfjärilar är egentligen en lite felaktig benämning på de fjärilar som inte är dagfjärilar. I Sverige finns det 116 arter dagfjärilar och mer än 2400 arter ’nattfjäriBehaviour of male moths and electrophysiological responses of male pheromone-specific olfactory receptor neurones were studied in two model species, the oriental fruit moth Grapholita molesta and the turnip moth Agrotis segetum. The studies were aimed at elucidating the relative importance of different mating disruption mechanisms. In a wind tunnel study of G. molesta, behavioural response to a r

Anti-C1q antibodies in systemic lupus erythematosus.

Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study.

Global surveillance of cancer survival 1995-2009 : analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million

Antagningsordning för utbildning på forskarnivå. Beslut 2024-06-18

Microsoft Word - ANTAGNINGSORDNING beslut US 2024-06-18 test Sida 1 av 28 Universitetsstyrelsen BESLUT Diarienummer I G 9 6251/2004 LS 2012/719) STYR 2017/409 STYR 2024/288 Datum 2024-06-18 Innehåll Antagningsordning för utbildning på forskarnivå vid Lunds universitet 1. Inledning .................................................................................. 3 2. Information om ledig utbildnin

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-08/antagningsordning-for-utbildning-pa-forskarniva-vid-Lunds-universitet.pdf - 2026-05-07

Civilingenjör i teknisk fysik

Civilingenjör i teknisk fysik | LTH, Lunds Tekniska Högskola Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera

https://www.lth.se/utbildning/teknisk-fysik/ - 2026-05-07

Fabian.doc

Fabian.doc The syntax and pragmatics of exclamations and other expressive/emotional utterances1,2 FABIAN BEIJER 1 Introduction In the linguistic literature we find discussions and descriptions of linguistic phenomena such as EXPRESSIVE UTTERANCES, EXCLAMATORY UTTERANCES, EXPRESSIVE SENTENCES, EXCLAMATIONS, EXCLAMATIVES, and EXPRESSIVE SPEECH ACTS. Linguists have thus observed that there are emotio

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol02/Fabian.pdf - 2026-05-07

This is the title of my paper

This is the title of my paper Syntactic autonomy and result clauses* JONATHAN R. WHITE, HÖGSKOLAN DALARNA Abstract In this paper I look at whether the syntactic properties of the result clause construction in English can be predicted from its semantic properties. I adopt the semantics of Meier (2000, 2003) which treats the construction as having a hidden conditional meaning. The structure she prop

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol04/white-wp-04.pdf - 2026-05-07

WPSS ON -a & -at

WPSS ON -a & -at Working Papers in Scandinavian Syntax 100 (2018), 20–40 Revisiting the etymology of the Norse negative enclitic -a/-at1 Eric Lander University of Gothenburg In this paper I present and discuss the etymological hypotheses that have been put forth through the years for Norse -a/-at ‘not’, a negative particle suffixed to finite and imperative verbs, found primarily in Old Icelandic a

https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_grimm/working_papers/2018-jun/Lander.pdf - 2026-05-07

Removing the Middleman: Blockchain and Human Rights - The Raoul Wallenberg Institute of Human Rights

Removing the Middleman: Blockchain and Human Rights - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Ev

https://rwi.lu.se/2018/04/03/blockchain-human-rights-2/ - 2026-05-07

Human oral, gut, and plaque microbiota in patients with atherosclerosis

Periodontal disease has been associated with atherosclerosis, suggesting that bacteria from the oral cavity may contribute to the development of atherosclerosis and cardiovascular disease. Furthermore, the gut microbiota may affect obesity, which is associated with atherosclerosis. Using qPCR, we show that bacterial DNA was present in the atherosclerotic plaque and that the amount of DNA correlate

Osannolika händelser och den svenska realistiska romanen : Ett estetiskt och existentiellt bekymmer

Avhandlingens ämne är osannolika händelser i den realistiska romanen. Den övergripande idén är att realismen utmärks av att osannolika händelser hanteras utifrån ett dubbelt perspektiv: både som ett existentiellt och ett estetiskt bekymmer. Som ett existentiellt bekymmer representerar den narrativa fiktionsberättelsens osannolika händelser den ständigt närvarande möjligheten att en oförutsägbar ocThis thesis deals with improbable events in the realistic novel. The overarchingidea is that realism is distinguished by dealing with improbable events on thebasis of a double perspective: both as an existential and as an aesthetic problem.As an existential problem the improbable events of narrative fiction representthe constantly present possibility of an unexpected and unforeseen event suddenly

Survival of Patients With Angina Pectoris Undergoing Percutaneous Coronary Intervention With Intracoronary Pressure Wire Guidance

Background: Intracoronary pressure wire measurement of fractional flow reserve (FFR) provides decision-making guidance during percutaneous coronary intervention (PCI). However, limited data exist on the effect of FFR on long-term clinical outcomes in patients with stable angina pectoris. Objectives: The purpose of this study was to determine the association between the usage of FFR and all-cause m

Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity

The intestine contains some of the most diverse and complex immune compartments in the body. Here we describe a method for isolating human gut-associated lymphoid tissues (GALTs) that allows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoid follicles (SM-ILFs and M-ILFs, respectively) as well as in GALT-free intestinal lamina propria (LP). SM-ILF and

The chemical compositions of accreted and in situ galactic globular clusters according to SDSS/APOGEE

Studies of the kinematics and chemical compositions of Galactic globular clusters (GCs) enable the reconstruction of the history of star formation, chemical evolution, and mass assembly of the Galaxy. Using the latest data release (DR16) of the SDSS/APOGEE survey, we identify 3090 stars associated with 46 GCs. Using a previously defined kinematic association, we break the sample down into eight se

The Open Cluster Chemical Abundances and Mapping Survey. IV. Abundances for 128 Open Clusters Using SDSS/APOGEE DR16

The Open Cluster Chemical Abundances and Mapping (OCCAM) survey aims to constrain key Galactic dynamical and chemical evolution parameters by the construction of a large, comprehensive, uniform, infrared-based spectroscopic data set of hundreds of open clusters. This fourth contribution from the OCCAM survey presents analysis using Sloan Digital Sky Survey/APOGEE DR16 of a sample of 128 open clust