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Myeloid-derived suppressor cells (MDSCs) are known to contribute to immune evasion in cancer. However, the function of the human granulocytic (G)-MDSC subset during tumor progression is largely unknown, and there are no established markers for their identification in human tumor specimens. Using gene expression profiling, mass cytometry, and tumor microarrays, we here demonstrate that human G-MDSC

Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV

The central component of the complement cascade, C3, is involved in various biological functions, including opsonization of foreign bodies, clearance of waste material, activation of immune cells, and triggering of pathways controlling development. Given its broad role in immune responses, particularly in phagocytosis and the clearance of microbes, a deficiency in complement C3 in humans is often

To provide a valid consent to – or refusal of – medical intervention, a patient must be legally capable to decide. This dissertation evaluates and compares when the assessment of mental abilities to refuse – or consent to – somatic medical intervention is required in England, Russia and Sweden, and what criteria must be applied to assess the ability to decide about somatic medical interventions in

For women and children, especially those who are poor and disadvantaged, to benefit from primary health care, they need to access and use cost-effective interventions for maternal, newborn, and child health. The challenge facing weak health systems is how to deliver such packages. Experiences from countries such as Iran, Malaysia, Sri Lanka, and China, and from projects in countries like Tanzania

This roadmap, developed through collaborative discussions at the recent AI PolicyResearch Summit, reflects a shared vision for advancing research on responsibleAI policy and governance. It emphasizes the critical role of policy research inensuring that AI development is guided by robust evidence, ethicalconsiderations, and a commitment to sustainability and inclusivity. By prioritizingtransparency

OBJECTIVE: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed on CD4(+) effector memory T cells and regulatory T cells; however, its role on these functionally opposing cell types in atherosclerosis is not fully understood.APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice (Ldlr(-/-)) were lethally irradiated and reconstituted with e

The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, c

Background: Persistent circulating cell-free tumor DNA (ctDNA) detection during neoadjuvant treatment of early-breast cancer (EBC) indicates high-risk disease. Detection of ctDNA post-resection of EBC (molecular residual disease, MRD) indicates occult metastatic disease and impending disease relapse. For ctDNA to be integrated into EBC management, accessible and scalable diagnostic tools are requi

Background: The recent expansion of immunotherapy for stage IIB/IIC melanoma highlights a growing clinical need to identify patients at high risk of metastatic recurrence and, therefore, most likely to benefit from this therapeutic modality. Objective: To develop time-to-event risk prediction models for melanoma metastatic recurrence. Methods: Patients diagnosed with stage I/II primary cutaneous m

Popular Abstract in Swedish Lyhördhet. Studenters uppfattningar av lyhördhet i omvårdnad och utbildningAvhandlingen handlar om lyhördhet i omvårdnad och utbildning. Ett problem är att ordet lyhördhet endast finns på de nordiska språken. I engelska, tyska och franska ordböcker omskrivs lyhördhet på olika sätt utan att egentligen ges hela den betydelse som det har i nordiska språk. I engelskan översThe word lyhördhet has its origin in Danish and exists only in the Nordic languages. In this summary the Swedish word is used in italics without translation.The subject of this dissertation is lyhördhet in nursing education, what lyhördhet can be and how it can be made a valuable part of educations involving care of human beings, in particular nursing education.The term lyhördhet has not previousl

According to our current cosmological model, galaxies like the Milky Way are expected to experience many mergers over their lifetimes. The most massive of the merging galaxies will be dragged towards the disc plane, depositing stars and dark matter into an accreted disc structure. In this work, we utilize the chemodynamical template developed in Ruchti et al. to hunt for accreted stars. We apply t

We report the discovery from K2 of a transiting planet in an 18.25-d, eccentric (0.19 ± 0.04) orbit around K2-99, an 11th magnitude subgiant in Virgo. We con- firm the planetary nature of the companion with radial velocities, and determine that the star is a metal-rich ([Fe/H] = 0.20 ± 0.05) subgiant, with mass 1.60+0.14 -0.10 M⊙ and radius 3.1 ± 0.1 R⊙. The planet has a mass of 0.97 ± 0.09 MJup a

We announce the discovery of K2-139 b (EPIC 218916923 b), a transiting warm-Jupiter (Teq = 547± 25 K) on a 29-d orbit around an active (logR' HK =-4.46±0.06) K0V star in K2 Campaign 7.We derive the system's parameters by combining the K2 photometry with groundbased follow-up observations. With a mass of 0.387 -0.033+0.075 MJ and radius of 0.808 -0.033+0.034 RJ, K2-139 b is one of the transiting wa

Technical measurements allow an objective assessment of MSD risk factors at work. There is a need for common standards regarding data collection and processing, as well as an exchange platform storing measurement data of occupational physical activity and workload for further analysis. Several research institutes started a feasibility study to work on developing standards for assessment of risk fa

We have used the FERMI free-electron laser to perform time-resolved photoelectron imaging experiments on a complex group of resonances near 15.38 eV in the absorption spectrum of molecular nitrogen, N2, under jet-cooled conditions. The new data complement and extend the earlier work of Fushitani et al. [Opt. Express 27, 19702–19711 (2019)], who recorded time-resolved photoelectron spectra for this

Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications of inflammation. C

BACKGROUND Trials evaluating the omission of completion axillary-lymph-node dissection in patients with clinically node-negative breast cancer and sentinel-lymph-node metastases have been compromised by limited statistical power, uncertain nodal radiotherapy target volumes, and a scarcity of data on relevant clinical subgroups. METHODS We conducted a noninferiority trial in which patients with cli

The purpose of the thesis is to analyse the problems of hybrid mismatch arrangements within the EU and how single taxation, which requires income to be taxed once, not more or less, can be secured under EU law. After the amendments of the Parent-Subsidiary Directive (PSD), where an anti-hybrid rule was enacted, the legal environment for companies within the European Union changed. Parent compani