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Polarization position angle standard stars : a reassessment of θ and its variability for seventeen stars based on a decade of observations

Observations of polarization position angle (θ) standards made from 2014 to 2023 with the High Precision Polarimetric Instrument (HIPPI) and other HIPPI-class polarimeters in both hemispheres are used to investigate their variability. Multiband data were first used to thoroughly recalibrate the instrument performance by bench-marking against carefully selected literature data. A novel co-ordinate

Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants : A Patient-Level Meta-Analysis From COMBINE AF

BACKGROUND: Despite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk. METHODS AND RESULTS: Individual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration

Nasogastric tube after oesophagectomy and risk of anastomotic leak : a Nordic, multicentre, open-label, randomised, controlled, non-inferiority trial

BACKGROUND: Oesophagectomy, a corner stone in curative treatment of oesophageal cancer, is a complex procedure with high complication rates. Postoperative gastric tube decompression is debated and some centres are abandoning routine nasogastric (NG) tube use. We hypothesised that postoperative NG tube removal is non-inferior to five days of NG tube decompression, with regard to the risk of anastom

The cystic fibrosis pathogen Achromobacter xylosoxidans inhibits biofilm formation of Pseudomonas aeruginosa

Background. Achromobacter xylosoxidans and Pseudomonas aeruginosa are two pathogens that cause persistent airway infections in individuals with cystic fibrosis (CF). The persistence of P. aeruginosa is partly due to a high capacity to form biofilms and the ability to exert antagonism against other bacteria. Loss of microbial diversity in conjunction with chronic P. aeruginosa colonization is

EDGE : A new model for nuclear star cluster formation in dwarf galaxies

Nuclear star clusters (NSCs) are among the densest stellar systems in the Universe and are found at the centres of many spiral and elliptical galaxies, and up to 40 percent of dwarf galaxies. However, their formation mechanisms, and possible links to globular clusters (GCs), remain debated. This paper uses cosmological simulations of dwarf galaxies at a spatial resolution of pc to present a new fo

Sensitization of Staphylococcus aureus to methicillin and other antibiotics in vitro and in vivo in the presence of HAMLET

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a protein-lipid complex from human milk with both tumoricidal and bactericidal activities. HAMLET exerts a rather specific bactericidal activity against some respiratory pathogens, with highest activity against Streptococcus pneumoniae, but lacks activity against most other bacterial pathogens, including Staphylococci. Still, ion trans

Consumption of ultraprocessed food and development of chronic kidney disease : the Tianjin Chronic Low-Grade Systemic Inflammation and Health and UK Biobank Cohort Studies

BackgroundMany ultraprocessed food (UPF)-derived by-products may play a role in the development of chronic kidney disease (CKD). Although several studies have assessed the association of UPFs with kidney function decline or CKD in various countries, no evidence has been shown in China and the United Kingdom.ObjectivesThis study aims to evaluate the association between UPF consumption and risk of C

A Preliminary Checklist for Capturing Baseline Situations in Studying the Impacts of Agile Practices Introduction

To assess the benefits of introducing Agile practices, it is important to get a clear understanding of the baseline situation, i.e. the situation before their introduction. Without a clear baseline, we cannot properly assess the extent of impacts, both positive and negative, of introducing Agile practices. This paper provides a preliminary guideline to help researchers in capturing and reporting b

APOGEE Data Releases 13 and 14 : Stellar Parameter and Abundance Comparisons with Independent Analyses

Data from the SDSS-IV/Apache Point Observatory Galactic Evolution Experiment (APOGEE-2) have been released as part of SDSS Data Releases 13 (DR13) and 14 (DR14). These include high-resolution H-band spectra, radial velocities, and derived stellar parameters and abundances. DR13, released in 2016 August, contained APOGEE data for roughly 150,000 stars, and DR14, released in 2017 August, added about

New strategies for the conduct of clinical trials in paediatric Pulmonary Arterial Hypertension (PAH): Outcome of a multi-stakeholder meeting with patients, academia, industry and regulators held at EMA on Monday 12th June 2017

Aims: Drug development for paediatric pulmonary arterial hypertension (PAH) ispressingly needed. Experts from the US Food and Drug Administration, EuropeanMedicines Agency, Health Canada, key opinion leaders, academia, patients, and industry representatives held a workshop on 12th June 2017 dedicated to addressing challenges and unmet needs. This report summarises the approaches proposed during th

Fundamental effective temperature measurements for eclipsing binary stars-III. SPIRou near-infrared spectroscopy and CHEOPS photometry of the benchmark G0V star EBLM J0113+31

EBLM J0113+31 is a moderately bright (V = 10.1), metal-poor ([Fe/H] ≈-0.3) G0V star with a much fainter M dwarf companion on a wide, eccentric orbit (= 14.3 d). We have used near-infrared spectroscopy obtained with the SPIRou spectrograph to measure the semi-amplitude of the M dwarf's spectroscopic orbit, and high-precision photometry of the eclipse and transit from the CHEOPS and TESS space missi

Immunity to Rotavirus infection across ages

Rotavirus (RV) is a double-stranded RNA virus that mainly affects young children under the age of five years. It is one of the leading causes of dehydrating gastroenteritis. Every year, about 200,000 child deaths occur due to RVinfection. Vaccines exist and are in use worldwide. However, these vaccines' efficacy is relatively low in countries where deaths due to the virus are high.The aim of the w

IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage

Conventional dendritic cells (cDCs) consist of two major functionally and phenotypically distinct subsets, cDC1 and cDC2, whose development is dependent on distinct sets of transcription factors. Interferon regulatory factor 8 (IRF8) is required at multiple stages of cDC1 development, but its role in committed cDC1 remains unclear. Here, we used Xcr1-cre to delete Irf8 in committed cDC1 and demons

Overlapping morphological, immunohistochemical and genetic features of superficial CD34-positive fibroblastic tumor and PRDM10-rearranged soft tissue tumor

Superficial CD34-positive fibroblastic tumor (SCD34FT) is a recently recognized soft tissue tumor that is considered to be of borderline malignancy. The pathogenesis of this tumor remains incompletely understood, but it has been suggested that SCD34FT overlaps with tumors showing fusions involving the PRDM10 gene. Previous analyses of PRDM10-rearranged tumors have demonstrated that they have a dis

Age Assessment of Unaccompanied Minors in Sweden and the Rights of Children

Flyktingströmmen 2015 medförde en stor ökning av antalet asylsökande till Sverige, varav många anförde att de var ensamkommande minderåriga. Inte sällan ifrågasatte myndigheterna sökandenas åldrar, vilket medförde ett behov av åldersbedömningar. Regeringen gav då i uppdrag att skyndsamt utveckla och påbörja medicinska åldersbedömningar, och en metod för detta utvecklades hastigt. Enbart under 2017In 2015, Sweden saw a large influx of asylum-seekers into the country, many of whom claimed to be unaccompanied minor. Without personal documents to attest their age, the authorities often doubted these claims of minority, prompting a need for age assessment. The government called for medical age assessments to be developed and introduced and a method for medical age assessment was hastily develop

Reduction in Platelet Reactivity With Prasugrel 5 mg in Low-Body-Weight Patients Is Noninferior to Prasugrel 10 mg in Higher-Body-Weight Patients: Results From the FEATHER Trial.

OBJECTIVES: The aim of this study was to confirm prior modeling data suggesting that prasugrel 5 mg in low-body-weight (LBW) patients would be noninferior to prasugrel 10 mg in higher-body-weight (HBW) patients as assessed by maximal platelet aggregation (MPA). BACKGROUND: Prasugrel 10 mg reduced ischemic events compared with clopidogrel 75 mg but increased bleeding, particularly in LBW patients.

Rising antimicrobial resistance in urinary tract infections in Türkiye: an urgent need for update on regional treatment strategies and for enhanced antimicrobial stewardship efforts

PurposeTürkiye ranks among the highest in antibiotic consumption within OECD countries and faces growing challenges from multidrug-resistant uropathogens. Nationwide, resistance-guided treatment data remain scarce. The main objective of this work is to provide a comprehensive nationwide data on antibiotic resistance patterns among uropathogens to guide treatment options in urinary tract infections

The EBLM Project– XI. Mass, radius, and effective temperature measurements for 23 M-dwarf companions to solar-type stars observed with CHEOPS

Observations of low-mass stars have frequently shown a disagreement between observed stellar radii and radii predicted by theoretical stellar structure models. This ‘radius inflation’ problem could have an impact on both stellar and exoplanetary science. We present the final results of our observation programme with the CHaracterising ExOPlanet Satellite (CHEOPS) to obtain high-precision light cur

Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons

Apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer's disease (AD), is vital for understanding cellular processes involved in AD pathogenesis. Evidence implicates endosomes as a central player in AD, where endosomal enlargement in neurons is among the earliest changes in AD. This enlargement was reported to be enhanced in APOE4 carriers. Cells internalize ApoE into endosomes for

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1 M 7896:1-47 Landskap: Skåne Upptecknat av: August L Nordgren Härad: Frosta, N Åsbo Adress: Högseröd, Löberöd Socken: N Rörum, Färingtofta, Riseberga Berättat av: Uppteckningsår: 1941 Född år 1882 i Länghult, Hallaröd sn Arbetsgillen (HC 7) Valborgsmässoeld (Etn I:12) (Självbiografi) Fortsättning på mina uppteckningar och memoarer, händelser från Riseberga sn som jag minns när jag som en liten pa

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