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Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, ΛCDM. This is motivated by a range of apparently serious theoretical issues, involving such questions as the cosmological constant problem, the particle nature of dark matter, the validity of general relativity on large scales, the existence of anomalies in
New synthetic hybrid materials and their increasing complexity have placed growing demands on crystal growth for single-crystal X-ray diffraction analysis. Unfortunately, not all chemical systems are conducive to the isolation of single crystals for traditional characterization. Here, small-molecule serial femtosecond crystallography (smSFX) at atomic resolution (0.833 Å) is employed to characteri
Rhesus macaques (RMs) are a vital model for studying human disease and are invaluable to preclinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for antibody-encoding genes within the immunoglobulin (IG) loci. The complexity of the IG loci has historically made them challenging to characterize accurately. To
BACKGROUND: Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.METHODS: Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteom
Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.MethodsUsing data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellula
Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammator
The typical methodology for comparing simulated galaxies with observational surveys is usually to apply a spatial selection to the simulation to mimic the region of interest covered by a comparable observational survey sample. In this work, we compare this approach with a more sophisticated post-processing in which the observational uncertainties and selection effects (photometric, surface gravity
Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va
There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. Dur
Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma
Background Studies in many countries have reported higher lung cancer incidence and mortality in individuals with lower socioeconomic status. Methods To investigate the role of smoking in these inequalities, we used data from 391 251 participants in the European Prospective Investigation into Cancer and Nutrition study, a cohort of individuals in 10 European countries. We collected information on
Background Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods Individual data for 23 257 women with ovarian cancer (cases) a
We present the first results of K2-OjOS, a collaborative project between professional and amateur astronomers primarily aimed to detect, characterize, and validate new extrasolar planets. For this work, 10 amateur astronomers looked for planetary signals by visually inspecting the 20 427 light curves of K2 campaign 18 (C18). They found 42 planet candidates, of which 18 are new detections and 24 ha
Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases re-quires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro dia
Chapter X “Respect” Human Rights: Concept and Convergence Radu Mares1 (forthcoming in Law, Business and Human Rights: Bridging the Gap (Robert C. Bird, Daniel R. Cahoy, & Jamie Darin Prenkert, eds., Elgar Publishing Ltd., forthcoming 2014) Abstract The Guiding Principles on Business and Human Rights (‘GPs’) were unanimously endorsed in 2011 in the UN Human Rights Council and also recorded an unpre
https://rwi.lu.se/app/uploads/2014/03/Respect-Human-Rights-Concept-and-Convergence.pdf - 2026-05-03
In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe
1 Business and Human Rights After Ruggie: Foundations, the Art of Simplification and the Imperative of Cumulative Progress* Radu Mares in R. Mares (ed.), The UN Guiding Principles on Business and Human Rights – Foundations and Implementation, Martinus Nijhoff Publishers (Leiden, Boston 2012) pp. 1-50 1. Introduction The United Nations (UN) Special Representative of the Secretary-General (SRSG) o
https://rwi.lu.se/app/uploads/2012/06/Business-and-Human-Rights-After-Ruggie.pdf - 2026-05-03
Acc nr: M 6596:1-31 Landskap;: Småland Upptecknat av: Carl Viking Härad: Uppvidinge Adress: Furåkra, Kråksmåla sn Socken: Älghult Berättat av: Carl Viking Uppteckningsår: 1940 Född år: 1874 i Älghult sn Uppteckningen utgör fortsättning på minnen från barndomshemmet och i tjänst som bonddräng intill dess jag nått 22 år. Vol: 6 Sidor 137-167 ----------------------------------------------------------
https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/M6596.pdf - 2026-05-02
a k t u el lt o m v e t ensk a p o ch h ä l sa • m a j 20 07 Minska smärtan! Maj 2007 Denna tidskrift ges ut av Medicinska fakulteten vid Lunds universitet och Universitetssjukhuset i Lund & Universitetssjukhuset MAS vid Region Skåne Aktuellt om Vetenskap & hälsa a k t u el lt o m v e t ensk a p o ch h ä l sa • m a j 20 07 Smärtspecialister koncentrerar sig på smärtans känslomässiga konsekvenser
https://www.vetenskaphalsa.se/wp-content/uploads/2010/08/Aktuellt-om-Vetenskap-H%C3%A4lsa-Minska-sm%C3%A4rtan-07.pdf - 2026-05-02
