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Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a B
This study focusses on the hydrogeology of Urema Graben, especially possible interactions between surface water and groundwater around Lake Urema, in Gorongosa National Park (GNP). Lake Urema is the only permanent water source for wildlife inside GNP, and there are concerns that it will disappear due to interferences in surface-water/groundwater interactions as a result of changes in the hydraulic
In the face of growing sustainability challenges, pressure on businesses to decouple environmental impacts from growth is mounting. New sustainable business models can be a systemic driver for change in industry and the wider business innovation literature suggests that strategic design approaches can be at the heart of business model innovation. One such approach, service design, involves solving
Traditional frontier literature identifies a positive correlation between land availability and fertility. A common explanation is that the demand for children as labour is higher in newly established frontier regions compared to older and more densely populated farming regions. In this paper we contribute to the debate by analysing the relationship between household composition and land availabil
The Syrian civil war began in 2011 after wide-spread protests were met with violence from the government, and since then both Russia and the U.S. have gotten involved in the conflict. Strategic narratives regarding the conflict and the involved nation’s actions and motives have been told, constructed to benefit the interests of these states. The purpose of this paper is to answer to what extent CN
The European Union’s development policy has the primary goal to eradicate poverty at the global level and to promote sustainable development. But is the EU doing enough effort to engage the voices and the needs of the poor in order to deliver locally informed aid projects? Emerging from these complex questions, the following research explores the importance and resourcefulness of an institutionali
This thesis investigates and compares metaphors used in the context of psychotherapy by people who experience various forms of maladaptive anxiety and anxiety disorders (anxiety sample, AS) and people who experience stress caused by various events in their lives (stress sample, SS). It is grounded in a cognitive-semiotic theory called the Motivation & Sedimentation Model (MSM), which defines t
Across the globe, persons with disabilities do not enjoy equitable access to social, economic, and human capital compared to their non-disabled counterparts, and are politically, economically and culturally disenfranchised. Ghana ratified the Convention on the Rights of Persons with Disabilities (CRPD) in 2012 and is thereby obliged to amend their national disability laws, making them compatible w
The Sveconorwegian orogeny (c. 1 Ga) lead to the recrystallization of large parts of southwestern Sweden, with widespread metamorphism as well as local migmatization. The Idefjorden Terrane, which has been studied less extensively than the nearby Eastern Segment, is divided by the Göta Älv Shear Zone and the Dalsland Boundary Thrust into two main units; the Western and Median Segments. A garnet am
In this study carry trade activity in AUD, CAD, EUR and YEN vis the USD between 2014 – 2019 was analysed. The first approach employs a VECM, analyse evidence of carry trade recorded in the exchange rate pairs Futures, Forwards and Spot. Results show evidence of carry with the USD being the target currency, while the others being the funding currency. However, the AUD shows specific traits of carry
Learners of Japanese face many challenges when trying to create linguistic gender identities within the language. With little real experience to draw from, some learners may resort to fictional sources of exposure in order to create masculine identities. Ze and zo, two sentence-final particles that are often associated with male speech are featured quite heavily in fictional speech, but rarely occ
The fashion industry has always been a synonym of new trends, creativity, design and a form of expression and individuality. Notwithstanding, the impact on the environment and the development of societies derived from the production and consumption of fashion has been underestimated. The current system is extremely polluting and wasteful, and it is closely related to poverty, gender issues and exp
The textile industry is known for its complex global supply chains and being subject to a raft of sustainability issues. As renowned apparel brands begin to adopt circular economy principles to close their material loop, upcycling of post-industrial waste streams presents a promising solution. The Oberalp Group has taken initiatives to address its material sustainability issues by starting some up
Denna uppsats ämnar att undersöka medvetenhet kring informationssäkerhet hos beslutsfattare i deras användning av SaaS-applikationer i affärsverksamhet. Denna undersökning görs med hjälp av fem semistrukturerade telefonintervjuer med beslutsfattare inom olika branscher. Tre delområden för informationssäkerhet har identifierats i litteraturgenomgången. Dessa faktorer är: sekretess, tillgänglighet o
Trots att det finns stora möjligheter för att finna synergier mellan övergångsrättvisa och företagande och mänskliga rättigheter har de två forskningsfälten fram tills nyligen sällan undersökts ihop. Denna uppsats har som övergripande mål att bidra till en bättre förståelse för hur de två fälten interagerar när stater rör sig från pågående väpnade konflikter till post-konfliktfaser. I synnerhet ämThe fields of transitional justice and business and human rights have until recently seldom been examined jointly, despite the fact that their approaches reflect plenty of opportunities for potential synergies. This thesis bears the overarching aim of contributing to a greater understanding of how the two fields interact when states are transitioning from active armed conflict to post-conflict pha
The harbor porpoise is a small toothed whale with a widespread distribution, which spans the temperate and boreal waters of the northern hemisphere. As echolocating marine mammals, harbor porpoises rely heavily on acoustic signals, and it has been reported that vessel traffic can cause disturbances to these animals. The waters around the Kullaberg peninsula are an important breeding and nursing gr
Morphologically, the two corticoous species Rinodina pityrea and R. colobina are characterized by their dark blue-green blastidiate thallus and black plain or convex apothecia, with a light grey thallus margin. Rinodina pityrea and R. colobina are currently on the Swedish Red List as vulnerable (VU) and endangered (EN), respectively. They are hard to distinguish from Caloplaca chlorina in sterile
