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Background. In a search for immunosuppressive drugs having novel mechanisms, monocarboxylate transporter (MCT-1) inhibitors were identified that markedly inhibited immune responses. Here, we report the effects of AR-C117977, a potent MCT-1 inhibitor, on alloimmune responses in the rat. Methods. In vitro activity was determined in a rat mixed lymphocyte response (MLR). In vivo activity was tested i
Popular Abstract in Swedish Att klara sig trots allt: Den sociala och produktiva dynamiken hos småbönderna i de halvtorra områdena i Iringa i norra Tanzania. Det är inte lätt att överleva som småbonde i de halvtorra områdena i Iringa och på liknande platser i Afrika. Man kontrollerar knappast sin egen livssituation. Regnen är opålitliga, priser, marknadsföring och politiska ingrepp är oförutsägbaWhile much of semi-arid Africa is still sparsely populated with unused land, there are everywhere pockets of high and increasing population density in attractive locations. Small-scale farmers can respond to beginning land-scarcity in a number of ways. Through migration, through diversification of livelihoods, or through changes in their farming system. Which solution is chosen, depends not only o
A 14C-dated magnetostratigraphy of absolute declination and inclination between 12500 and 10000 14C yr BP was recently developed for southern Sweden. Recently also the Swedish geochronological time-scale, based on c. 11 500 annually deposited clay-varves, was connected with the present. It should therefore be possible to compare the two chronologies with a reliable magnetostratigraphic record in a
Electron paramagnetic resonance (EPR) spectroscopy is one of the major techniques used to analyse the structure and function of the water oxidising complex (WOC) in Photosystem II. The discovery of an EPR signal from the S0 state has opened the way for new experiments, aiming to characterise the S0 state and elucidate the differences between the different S states. We present a review of the bioch
Popular Abstract in Swedish De semi-arida regionerna i norra Kina är drabbade av många faktorer som påverkar miljön negativt, t.ex. ökenspridning, vind erosion, överbetning, uttömmande av naturresurser. Det redan hårda trycket på ekosystemen i dessa regioner har ökat sedan Kina införde marknadsekonomi. Reformerna sedan 1978 har lett till en snabb ökning av antalet betesdjur och en expansion av jorLand degradation is commonly perceived to be severe in many parts of semi arid China. The transition towards market economy since the 1978 reforms, have set marginal dry lands under added pressure in the form of increased livestock numbers and expanding cultivation on erosive soils. To evaluate land degradation since the reforms, this study focuses on mapping and analysing the biological productio
We studied the prevalence and intensity of the haemosporidian blood parasite Haemoproteus payevskyi in great reed warblers at Lake Kvismaren (6 years) and Lake Segersjo (3 years) in Sweden. Based on microscopic inspection of slides from 282 adult birds, 20.6% showed infection of H. payevskyi in circulating red blood cells in at least 1 year. For parasite prevalence, there was no difference between
colon; Prompted by previous studies suggesting that bulimia nervosa in women may be associated with elevated serum levels of testosterone, we have evaluated the possible effect of androgen antagonism in this condition. To this end, women meeting the DSM-IV criteria of bulimia nervosa, purging type, were treated in a one-center study with the androgen receptor antagonist flutamide (n = 9), the sero
An experimental and theoretical study of the effect of flow maldistribution from port to channel on the thermal performance of single and multipass plate heat exchangers is presented. In general, flow maldistribution brings about an increase in pressure drop and decrease of the thermal performance in heat exchangers. This deterioration is found to depend on flow rate, number of channels, and port
The increasing interest in the European historical log construction has heightened the need for comprehensive studies in different parts of the continent to view both the common features and the particular ones. The advanced Scandinavian research has revealed the problems of studying in depth and maintaining the log heritage when links to traditional carpentry are lost. One of the fortunate places
The mitochondrial oxidative phosphorylation system in plants possesses a variety of alternative pathways that decrease respiratory ATP production. These alternative pathways are mediated by three classes of bypass proteins: the type II NAD(P) H dehydrogenases (which circumvent complex I of the electron transport chain), the alternative oxidases (AOXs; which circumvent complexes III and IV) and the
We report a virtual Compton scattering study of the proton at low c.m. energies. We have determined the structure functions PLL–PTT/and PLT, and the electric and magnetic generalized polarizabilities (GPs) E(Q2) and M(Q2) at momentum transfer Q2=0.92 and 1.76 GeV2. The electric GP shows a strong falloff with Q2, and its global behavior does not follow a simple dipole form. The magnetic GP shows a
Popular Abstract in Swedish Inledning och hypotes Urininkontinens är ett vanligt förekommande tillstånd som förorsakar sänkt livskvalitet hos individen och dessutom stora kostnader för samhället. Förekomsten i befolkningen beror på hur snävt man definierar begreppet och är följaktligen mycket skiftande i olika undersökningar. Urininkontinens är ett symptom på en sjukdom eller ett tillstånd, inte eUrinary incontinence classification is based on symptomatology, presuming that each symptom originates in a separate pathophysiology and demands its unique therapy. Women often present a mixture of symptoms inconsistent with urodynamic diagnosis, especially regarding urgency. Treatment of stress incontinence often relieves urge symptoms indicating a common pathophysiology. Our aims were to investi
