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Granulomatosis with polyangiitis and microscopic polyangiitis are ANCA-associated vasculitides (AAVs). The Vasculitis Damage Index (VDI) quantifies damage. This study aims to determine the factors associated with long-term damage in the AAVs.
Candida albicans binds and utilizes human complement inhibitors, such as C4b-binding protein (C4BP), Factor H, and FHL-1 for immune evasion. Here, we identify Candida pH-regulated antigen 1 (Pra1) as the first fungal C4BP-binding protein. Recombinant Pra1 binds C4BP, as shown by ELISA and isothermal titration calorimetry, and the Pra1-C4BP interaction is ionic in nature. The Pra1 binding domains w
The Lund jet plane (LJP) is measured for the first time in tt¯ events, using 140 fb-1 of s=13 TeV pp collision data collected with the ATLAS detector at the LHC. The LJP is a two-dimensional observable of the sub-structure of hadronic jets that acts as a proxy for the kinematics of parton showers and hadron formation. The observable is constructed from charged particles and is measured for R=1.0 a
Following the adoption of the 2030 Agenda for Sustainable Development, multi-stakeholder partnerships (MSPs) have received renewed political attention. In several policy fields, MSPs have been criticized for a lack of accountability, resulting in efforts to redress this problem. However, it is still unclear how accountability challenges and shortcomings differ across partnerships operating within
As a part of our continuous search for oncogenic viruses in bronchial cancer, we extended our HPV studies to analyse also SV40, BKV, JCV and HCMV sequences in bronchial cancer and related these data with p53 codon 72 polymorphism. Fresh tumor samples from 78 patients with lung cancer were analysed for SV40, BKV, JCV, HCMV and HPV sequences by PCR. HPV genotypes were determined using reverse blot h
Advance pricing arrangement (“APA”) becomes a common tool to attract foreign investors to carry out their business in the Member States’ territory. The advantage of APA which providing legitimate expectations to the taxpayers is one of the reasons of why the companies file an APA request to the tax authorities. However, APAs are not free from issues or problems arose, especially in relation to t
Purpose: This paper explores the idea of the prudent entrepreneurial self, through re-conceptualizing prudence into the domain of entrepreneurial education, to unite the two processes of becoming enterprising and entrepreneurial. It is argued that developing a capacity for prudence among graduates involves past, present and conjecture forms of knowledge that the authors find in the interplay betwe
Aerosol particles are a complex component of the atmospheric system which influence climate directly by interacting with solar radiation, and indirectly by contributing to cloud formation. The variety of their sources, as well as the multiple transformations they may undergo during their transport (including wet and dry deposition), result in significant spatial and temporal variability of their p
Two new potential ligands of theDrosophila PS2 integrins have been characterized by functional interaction in cell culture. These potential ligands are a new Drosophila laminin α2 chain encoded by the wing blister locus and Ten-m, an extracellular protein known to be involved in embryonic pattern formation. As with previously identified PS2 ligands, both contain RGD sequences, and RGD-containing f
We describe a deep learning method to read hand-written records from the 16th century. The method consists of a combination of a segmentation module and a Handwritten Text Recognition (HTR) module. The transformer-based HTR module exploits both language and image features in reading, classifying and extracting the position of each word on the page. The method is demonstrated on a unique historical
Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among individuals with epilepsy, particularly those with drug-resistant forms. This review explores the complex multisystem mechanisms underpinning SUDEP, integrating recent findings on brain, cardiac, and pulmonary dysfunctions. Background/Objectives: The main objective of this review is to elucidate how seizures disrupt
Students’ possibilities to interact with peers have reduced drastically during the emergency transition to online teaching due to the Covid-19 pandemic. Students report on decreased motivation and other study related issues; hence, there is a need to better understand the effects of decreased interaction. The aim of the present exploratory study was to document changes in student networks, in rela
Bivalves are considered mainly filter-feeding organisms; they remove suspended particles including phytoplankton, zooplankton, and bacteria from the water column. Moreover, some bivalves can also feed via pedal-feeding, which is the uptake of organic matter from the sediment using cilia on the foot. Diplodon parallelopipedon is a native bivalve from South America, which can obtain their foo
This study aims to understand the construction process of legitimizing extrajudicial killings through analyzing text from print and electronic media and how they have been portrayed to the audience. It puts an effort to understand how Bangladesh government legitimize extra-judicial killings within a democratic framework of a country. Extrajudicial killing is a threat to modern societies. It has ad
Holma and Kroksbäck are two socially vulnerable, enclosed neighbourhoods in Malmö, a city in the south of Sweden. There is a development plan to integrate and strengthen these areas. The aim of this thesis was to analyse matters of spatial segregation in an urban development project. How these matters were addressed and what factors might have an impact on them are questions this paper try to answ
Art. 36 TFEU is an exception clause which provides that quantitative restrictions or measures having equivalent effect to quantitative restrictions falling under Art. 34 and 35 TFEU may be justified under certain circumstances. If a national measure can be considered liable to hindering the trade between Member States, the national measure can be justified by one of the derogations listed in Art.
Present uncertainties in key ventilation parameters, characterising the fire performance of facades, has necessitated clarification in the foundational understanding of the Fire Science Body of Knowledge. A test program conducted in collaboration between Lunds Universitet and the Kingspan Group, studied the influence of cavity widths and lateral ventilation conditions on the fire behaviour within
