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Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.
Adult neurogenesis is impaired in the hippocampus of transgenic R6 mouse models of Huntington's disease (HD). The phenotypes of R6 transgenic mice mimic several symptoms and signs of the disease (Li et al., 2005). They exhibit neurological and endocrine changes resembling some symptoms seen in humans. The reduction in neurogenesis is only apparent in the dentate gyrus as the number of newborn neur
Monetary policy has been suggested to show a fading impact on domestic inflation. Based on this, the study tests whether this has occurred with Swedish monetary policy over the period January 2000 – January 2020. This is done by studying the impact of monetary policy on consumer price inflation and real estate prices in Sweden, comparing the results to the United States. The used method consists o
Background: The classic Bernard-Soulier syndrome (BSS) is a rare inherited thrombocytopenia (IT) associated with severe thrombocytopenia, giant platelets, and bleeding tendency caused by homozygous or compound heterozygous variants in GP1BA, GP1BB, or GP9. Monoallelic BSS (mBSS) associated with mild asymptomatic macrothrombocytopenia caused by heterozygous variants in GP1BA or GP1BB may be a frequ
The polymerization of amino acids into proteins occurs on ribosomes, with the rate influenced by the amino acids being polymerized. The imino acid proline is a poor donor and acceptor for peptide-bond formation, such that translational stalling occurs when three or more consecutive prolines (PPP) are encountered by the ribosome. In bacteria, stalling at PPP motifs is rescued by the elongation fact
Understanding the role of technology characteristics and the context in the diffusion of new energy technologies is important for assessing feasibility of climate mitigation. We examine the historical adoption of nuclear power as a case of a complex large scale energy technology. We conduct an event history analysis of grid connections of first sizable commercial nuclear power reactors in 79 count
This thesis explores the impact of medical migration on the healthcare crisis in East Africa. With a qualitative research design of ten semi-structured interviews it shall help to understand the relationship between medical migration and the healthcare crisis in East Africa. Accordingly, by interviewing doctors with ties to East Africa and relevant experiences for the topic of study, the following
The number of international students in higher education is steadily increasing, so their experiences in the new environment is a topic gaining more and more interest from academics (Wu & Hammond, 2011). The current research suggests a model for determining international students’ happiness. The determining factors in the hypothesized model are university satisfaction, residential satisfaction
‘Rewilding’, or the return of degraded lands to a state of ‘wilderness’, is a bold attempt to resolve the world’s ecological challenges. It however does not address the division between nature and society, which lies at the core of the issues. According to Marshall Sahlins (1972) and Nurit Bird-David (1992), indigenous people relate to ‘nature’ in a markedly different way than Westerners. Capturin
Gold mining causes various negative social and environmental impacts in countries of extraction like Colombia. Voluntary and legal efforts to tackle these challenges have recently increased in Europe. To understand the complex supply chain and the impact of the newly evolved governance structures better, more research is needed. Based on a literature review and interviews, I identify important Eur
The introduction of the euro as a currency in physical existence in January 2002 was a major step in the European integration process. The purpose of this paper is to explore how a representative selection of 12 000 Europeans across all countries in the euro area view the effects of the euro five years after its introduction. The empirical analysis uses multinomial logistic regressions to explore
As regulations regarding energy use and emissions of CO2 equivalents in buildings become more stringent, the need for more accurate tools and improved methods for predicting these parameters in building performance simulations increases. In the first part of this project, a probabilistic method was developed and applied to the transient energy calculations and evaluated using a single-family dwell
SpoVD and PBP4b are structurally very similar high-molecular-weight, class B penicillin-binding proteins produced early during sporulation in Bacillus subtilis. SpoVD is known to be essential for endospore cortex synthesis and thereby the production of heat-resistant spores. The role of PBP4b is still enigmatic. Both proteins are synthesized in the cytoplasm of the mother cell. PBP4b remains in th
This book is about packaging design for sustainable development, the kind of design that can make our lives friendlier, our planet greener and our businesses richer. It is necessary and obvious that we need to move towards a more sustainable society, as we see more pollution in our oceans, more waste in our streets, more landfills and the tremendous waste of essential resources such as food on our
Abstract in Uncoded languagesIn this article we discuss four basic approaches to characterising droughts namely meteorological, hydrological, agricultural, and socioeconomic. In the first three approaches, drought is defined and measured as a physical phenomenon primarily related to the precipitation shortfall. Socioeconomic drought, nonetheless, is described and determined as the 'supply' and 'de
There has never been, and will never be, a randomized double-blind placebo-controlled trial demonstrating that exercise in youth, adulthood or old age reduces fragility or osteoporosis-related fractures in old age. The next level of evidence, a randomized, controlled but unblinded study with fractures as an end-point is feasible but has never been done. The basis for the belief that exercise reduc
