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BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder leading to progressive motor, cognitive and functional decline. Antidopaminergic medications (ADMs) are frequently used to treat chorea and behavioural disturbances in HD.OBJECTIVE: We aimed to assess how the use of such medications was associated with the severity and progression of the motor aspects of the
Background: Laparoscopic distal pancreatectomy (LDP) appears to be safe and effective as open distal pancreatectomy (ODP) for benign or borderline malignant lesion. However, studies comparing LDP with ODP in elderly patients are limited. The purpose of this study is to compare the clinical outcomes of these two several approaches in elderly patients. Methods: A retrospective analysis was carried o
Pseudomonas aeruginosa airway infection is common in cystic fibrosis (CF), a disease also characterized by abundant extracellular DNA (eDNA) in the airways. The eDNA is mainly derived from neutrophils accumulating in the airways and contributes to a high sputum viscosity. The altered environment in the lower airways also paves the way for chronic P. aeruginosa infection. Here, we show that mice wi
UNLABELLED: BACKGROUND AND AIMS: The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.METHODS: The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition
Objective: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neuro
The past decade has witnessed the opening of a yawning chasm between scholarly attempts to theorise European union and the political realities of the EU (European Union) in crisis. The decade that has witnessed the ascendency of political systems analysis, neoliberal assumptions of efficiency and Europeanisation studies within Europe has also seen the failure of intergovernmental attempts to refor
The article argues that dissident voices which attempt to theorise Europe differently and advocate another European trajectory have been largely excluded and left unheard in mainstream discussions over the past decade of scholarship and analysis. Dissident voices in European Union studies are those that seek to actively challenge the mainstream of the study of Europe. The article briefly examines
Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA--a modification that is critical for bacterial virulence. Here we show that the currently accepted Escherichia coli EF-P modification pathway is incomplete and lacks a final hydroxylation step mediated by YfcM, an enzyme distinct from deoxyhypusine hydroxylase that catalyzes the final
The environment contains different forms of ecological noise that can reduce the ability of animals to detect information. Here, we ask whether animals adapt their behavior to either exploit or avoid areas of their environment with increased dynamic visual noise. Threespined sticklebacks (Gasterosteus aculeatus) were immersed in environments with a simulated formof naturally occurring visual noise
Some insulin-dependent diabetic (IDDM) patients develop severe forms of retinopathy. Putative risk factors such as hypertension, poor metabolic control, nephropathy and growth hormone levels do not fully explain the progress of retinopathy in these patients. It has been discussed whether there is a genetic marker, since some diabetic patients without any known predisposing risk factors develop sev
The mechanism of action for the anti-arthritic effect of methotrexate (MTX) was investigated in rats with antigen-induced arthritis (AIA). Arthritis intensity was quantified as area under the curve (AUC) for the joint swelling. The response to MTX was in several respects similar to what is seen in the clinic. The drug reduced the AUC in a dose-dependent manner after oral weekly (2-4 mg/kg/week) or
The role of defensiveness and repressive coping style for the performance on a combined emotional Stroop and tachistoscopic identification task with masked and unmasked words was studied in a community sample. Defensiveness was associated with a decrease in Stroop interference for masked threat words, but not for unmasked threat words. The most robust results, however, were found with regard to ov
Abstract: Cellulose gelation in 2 M NaOH aqueous solution was followed by time resolved turbidity and rheology measurements. The kinetics of gelation is observed to change from several hours down to few seconds when the temperature is increased from 25 to 30 °C. The increase of turbidity upon gelation demonstrates the formation of larger cellulose aggregates, while wide angle X-ray scattering data
Two different learning models for a teachable agent were tested with respect to perceived intelligence, the protégé effect, and learning in Swedish grade 5 and 6 students. A strong positive correlation was found between perceived intelligence and the protégé effect, but no significant differences were found between the two different implementations of the learning algorithm. The results suggest th
Data generated over nearly two decades clearly demonstrate the importance of epigenetic modifications and mechanisms in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is less well established. The field of pharmacoepigenetics covers epigenetic biomarkers that predict response to therapy, therapy-induced epigenetic alterations as well as epigenetic
Background: Not being able to work has negative health, social and financial consequences. Persisting breathlessness is prevalent in working-aged people. Is it associated with lower workforce participation? This study, using the South Australian Health Omnibus, aimed to explore associations between paid workforce participation and persisting breathlessness intensity, and economic impacts on income
The aim of this chapter is to analyse how the governing capacity of current policy instruments might be affected in futures of smart mobility. In order to explore this issue, the authors make use of the so-called NATO (nodality, authority, treasure, organisation) framework for analysing two contrasting scenarios. The analyses show that the overall governing capacity of many of the policy instrumen
TRAIN2WIND is a PhD TRAINing school analysing enTRAINment in offshore WIND farms with computer models and experiments. By its very nature, a wind turbine extracts energy from the wind, which is replenished from the wind field on the sides and above due to the ambient turbulence. However, offshore the turbulence is lower, and wind farms are typically larger than onshore, therefore the wind can only
