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Recent work has shown that pressures inside dsDNA phage capsids can be as high as many tens of atmospheres; it is this pressure that is responsible for initiation of the delivery of phage genomes to host cells. The forces driving ejection of the genome have been shown to decrease monotonically as ejection proceeds, and hence to be strongly dependent on the genome length. Here we investigate the
Molecular characteristics were determined for native waxy maize starch and maize starch modified in different way (by mechanical treatment or/and acid hydrolysis). Recrystallisation behaviour was studied. Methods used in this study were MALLS, HPAEC-PAD, NMR, DSC, SEM, light microscopy. Five starch materials were subjected to storage under the same conditions in the presence of water (70 w/w%). Mo
The Hyttsjo granites occur in the extensively mineralised Langban-Nordmark area in the westernmost part of the Bergslagen ore province. They have been classified as late Svecokarelian granites due to their homogeneous and generally isotropic appearance in addition to a WR Rb/Sr age. Moreover, they have been considered as possible candidates for supplying essential metals to epigenetic mineralisati
Light microscopy and cryo-scanning electron microscopy showed that hyphae of Bipolaris sorokiniana adhered to the wax surfaces of barley leaves by means of an extensive extracellular matrix (ECM). Prehelminthosporol, the major non-host specific phytotoxin formed by B. sorokiniana was immunolocalized in large amounts in the ECM surrounding the hyphae. Similarly, esterase activity involved in degrad
BACKGROUND: The discriminative power of 48-h wireless esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease has not been clearly demonstrated, and the cutoff level for esophageal acid exposure generating the optimal sensitivity and specificity is unknown. SUBJECTS AND Patients with typical reflux symptoms and a distinct response to acid suppressive medication METHODS: underw
Gold compounds are widely used in the treatment of rheumatoid arthritis, but their mechanisms of action remain unclear. We demonstrate here that auranofin (AF) (0.1-3 microM), but neither the hydrophilic gold compounds aurothiomalate (ATM) and aurothioglucose nor methotrexate or D-penicillamine, inhibits the induction of interleukin 1 beta and tumor necrosis factor (TNF) alpha mRNA and protein by
Popular Abstract in Swedish Floran i ekplanteringar ? en effekt av miljö, spridning eller markhistoria? Bakgrund Europas befolkning ökande kraftigt efter industrialismens genombrott och som en följd av detta ökade behovet av åkermark för att försörja den växande skaran människor med mat. Mer och mer av den lövskog som tidigare täckte stora delar av norra Europa avverkades för att bli åkermark, In Europe, only small fragments of deciduous woodlands remain intact and species dependent on this ecosystem have declined. In southern Sweden, a shifting trend during the 20th century, with more afforestations on former arable land, resulted in new oak stands. These new stand are either on former arable fields or on continuously forested land. This thesis has its emphasis on colonization patterns
The cannabinoid 1 receptor (CB1R) has a well-established role in appetite regulation. Central CB1R antagonists, notably rimonabant, induced weight loss and improved the metabolic profile in obese individuals, but were discontinued due to psychiatric side-effects. The CB1R is also expressed peripherally, where its effects include promotion of liver fat accumulation, which consumes ATP. Type 2 diabe
Popular Abstract in Swedish Min avhandling består av sex delarbeten som redovisar olika undersökningar av ett värmestabilt enzym (xylanas). Detta enzym är isolerat från en bakterie (Rhodothermus marinus) som lever i varma källor (vid 55-77 °C) och enzymet förväntas alltså fungera vid dessa temperaturer. Enzymets uppgift i bakterien är att förse den med lagom långa kolhydratmolekyler som bakterien A gene encoding a multidomain xylanase from the thermophilic bacterium Rhodothermus marinus has been cloned, sequenced and produced in Escherichia coli . The gene product was found to be a 109 kDa protein consisting of five domains. The catalytic domain and the two polysaccharide binding domains (PBD, previously called carbohydrate binding domains) have been cloned and produced separately for func
The aerodynamics and kinematics behind the flight of animals are relatively unknown. Although animal flight has been studied for several hundreds of years, it is only in recent time that we have the technical abilities to study the mechanistic basis of animal flight. This thesis represents an attempt to widen the knowledge about animal flight by studying one of the most advanced flyers of the natu
A growing body of research suggests that a firm’s governance system can significantly impact the long-term value creative potential of an enterprise by disciplining and encouraging organizational efforts to pursue risky entrepreneurial projects. Following this stream of research, we present a study of the impact of ownership and board governance on entrepreneurship in small technology-based firms.
Within a UN Joint Programme titled “Enhancing the Capacity of Turkey to Adapt to Climate Change” a systems approach workshop was carried out in Adana, Turkey with broad stakeholder participation. The participants applied systems thinking approach, causal loop diagramming methodology and systems analysis to examine the potential impacts of projected climatic changes on natural ecosystems and socio-
Popular Abstract in Swedish Ledgångsreumatism (reumatoid artrit) är en allvarlig inflammatorisk led- och systemsjukdom som drabbar ungefär 1% av befolkningen. Den är sannolikt den vanligaste behandlingsbara orsaken till invaliditet i västerlandet. Under de senaste 10 åren har allt fler forskare uppmärksammat sjukdomens dåliga prognos och manat till en tidigare och mera effektiv behandling så snartRheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is
Popular Abstract in Swedish Faktor IX (FIX) är en molekyl som behövs för att blodet ska koagulera. Brist på FIX leder till blödarsjuka. För att öka den grundläggande förståelsen av hur FIX fungerar har vi gjort studier av en bit av FIX, som kallas för EGF1. EGF1 är en av två EGFmoduler som finns i FIX. De kallas EGFmoduler för att de liknar en annan molekyl, Epidermal Growth Factor. I denna avhandCoagulation factor IX (FIX) is a vitamin K-dependent serine protease zymogen that circulates in plasma. Defects in FIX cause the bleeding disorder hemophilia B. FIX contains a Gla module, two Epidermal Growth Factor (EGF) -like modules and a serine protease region. In this thesis, studies have been performed on the N-terminal EGF module, which binds one Ca2+. — The present results show that bindin
