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The calpain-10 gene (CAPN10) has been associated with type 2 diabetes, but information on molecular and physiological mechanisms explaining this association is limited. Here we addressed this question by studying the role of CAPN10 for phenotypes associated with type 2 diabetes and free fatty acid (FFA) metabolism. Among 395 type 2 diabetic patients and 298 nondiabetic control subjects from Finlan

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Ground-based FTIR measurements have been performed in the Arctic summer in July 1993 and June 1994 at 79 degrees N to study the zenith column densities of several trace gases in the undisturbed Arctic summer atmosphere. Zenith column densities of H2O, N2O, HNO3, NO2, NO, ClONO2, ClO, HCl, HF, COF2, OCS, SF6, HCN, CH4, C2H6, C2H2, CO, O-3, CFC-12, CFC-22, and CO2 were retrieved by line-by-line calc

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Experimental M-shell nickel spectra in the 14.4-16.5 nm region from the JET tokamak (from both divertor and limiter configurations) and from the reversed field pinch RFX have been simulated. These spectra include lines from five ionization states, namely from K-like N-i9+ to P-like Ni13+ ions. For the JET limiter configuration the spectrum upper wavelength limit was higher (18.0 nm) and lines from

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The rinsing step, in which yoghurt is displaced by water, was monitored in a dairy plant using electrical resistance tomography (ERT), with a new hygienic design of the ERT sensors. The same displacement situation was simulated using computational fluid dynamics (CFD) and showed good agreement with the ERT measurements. CFD was also used to study how different properties, such as flow velocity, wa

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Factors influencing uptake and levels of persistent pollutants (PCBs, p,p'-DDE) were investigated in 341 northern pike from 61 lakes in southern Scandinavia. Although the inflow of pollutants from the atmosphere was similar throughout the area studied, large differences in levels of PCBs and DDE in predatory fish were found between lakes. The factors primarily responsible for this variation appear

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0 Context.-Plasma anti-Xa and anti-IIa activities correlate with the dose of low-molecular-weight heparin, and D-dimer and thrombin-antithrombin complexes are markers of procoagulant activity. Objective.-To investigate the relationship between plasma coagulation parameters and patient characteristics, including renal function, thromboprophylaxis, and incidence of venous thromboembolism (VTE) in th

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Romans 2 has long been a crux interpretum. Among matters of dispute is the function and identity of Paul’s interlocutor(s) in the chapter. While scholars agree that the individual addressed in 2:17–29 is a Jew, there is no such consensus with respect to the identity of the person addressed in 2:1–5. On the one hand, the scholarly majority holds that this person is depicted as a Jew and that the sa

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Aim: To survey the entire population (n = 116) afflicted with severe haemophilia A or B born in Sweden over a 20-y period (1980-1999), and to examine the epidemiological, genetic and clinical aspects of development of inhibitors to factors VIII and IX (FVIII/FIX). Methods: One hundred of the subjects had haemophilia A and 16 had haemophilia B. All of these subjects had received prophylactic treatm

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This article investigates variations in two professions' adaption of quality reforms. The adaption of reforms is viewed as a part of the professions' legitimacy and identity processes. Literature in the area suggests that the adaption of reforms is influenced by the profession's knowledge base, professional norms, organizational belonging and organizational field. The two cases here on how doctors

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The effect of language-driven eye movements in a visual scene with concurrent speech was examined using complex linguistic stimuli and complex scenes. The processing demands were manipulated using speech rate and the temporal distance between mentioned objects. This experiment differs from previous research by using complex photographic scenes, three-sentence utterances and mentioning four target

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We have investigated the effect of an external magnetic field on the angular distribution and the linear polarization of the 2p(2)2p(5)3s(3)P(2)(o) -> 2s(2)2p(6) S-1(0) emission line in Ne- like ions. Since an electric dipole decay channel is opened by the magnetic field and competes with the inherent magnetic quadrupole transition, these properties strongly depend on the magnetic field strength,

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Background: Nonmedical prescription drug use (NMPDU) is a growing problem in many countries. Objectives: The aim of the present study was to report correlates of and compare different subtypes of NMPDU in the Swedish general population. Methods: Data were drawn from a Swedish national household survey conducted in 2008-2009. A stratified sample of 58,000 individuals aged 15 to 64 was randomly sele

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The structural and morphological characterizations of a chalcopyrite concentrate, collected from the Indian Copper Complex, Ghatshila, India, were carried out by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The concentrate powder was composed mainly of free chalcopyrite and low quartz in about 3:1 weight ratio. The particle size was about 100 mu m. Spe

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In Sierra Leone, West Africa, there are many people with disabilities in need of rehabilitation services after a long civil war. Purpose: The aim of this qualitative study was to explore the experiences of prosthetic and orthotic service delivery in Sierra Leone from the local staff's perspective. Method: Fifteen prosthetic and orthotic technicians working at all the rehabilitation centres providi

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Objective. To investigate the impact on ICD coding behaviour of a new case-mix reimbursement system based on coded patient diagnoses. The main hypothesis was that after the introduction of the new system the coding of chronic diseases like hypertension and cancer would increase and the variance in propensity for coding would decrease on both physician and health care centre (HCC) levels. Design. C

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Life-threatening intracardiac and great vessels thrombi are rare in neonates. Recombinant tissue plasminogen activator (rTPA) is used in adults to stimulate fibrinolysis and facilitate thrombus resolution. Its use in neonates, along with heparin, remains controversial because of potential risk of serious bleeding. We aim to present our experience with the use of thrombolytic agents in seven neonat

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The overall objective of this study is to examine how the institutional context of food safety affects and is affected by concerns for legitimacy and reputation. The paper employs a neo-institutional approach to analyzing the institutional field of food safety in a case study of a multinational food service provider where a tension between conflicting institutional logics implied a reputational ch

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We have post-compressed 25 fs (Fourier limit) amplified pulses in an argon-filled hollow-core fiber. The output pulses were compressed using a pair of wedges and chirped mirrors down to 4.5 fs (Fourier limit of 4.1 fs), which corresponds to less than two optical cycles. We then performed the characterization of the pulses by combining the d-scan and the STARFISH techniques. The temporal (and spect