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Universal screening for defective mismatch repair (dMMR) in colorectal cancer utilizes immunohistochemical staining for MLH1, MSH2, MSH6 and PSM2. Additionally, BRAF V600E mutations status and MLH1 hypermethylation should be performed to distinguish germline and somatic dMMR alterations. A decade of Danish population-based registries has been analysed regarding screening uptake, detection rate and
A parent’s life threating illness and death can significantly affect their children's wellbeing in both the short and long term. Support from professionals is recommended when parents lack the ability to help children cope with loss, bereavement, and grief. The overall aim of this dissertation was to illuminate professionals’ encounters with children of a seriously ill or deceased parent and to ex
The need to develop new and computationally efficient artificial intelligence models that accurately simulate river flows in data-scarce regions, considering not only current but also projected future climate change conditions is vital. In this study, a hybrid artificial neural network (ANN) model that combines HEC-HMS and the feed-forward neural network (FFNN) was developed in the Python programm
In urban property development projects, attention to the needs and aspirations of local communities is often neglected. Although some developers still consider local community stakeholders to be a potential threat to their developments, in many developed countries, stakeholder participation is embedded within statutory processes such as the formal planning process and is increasingly regarded as a
Background: Long-term recovery following critical COVID-19 has not been sufficiently studied. Objective: The primary objective was to describe changes in functional outcome and Health-Related Quality of Life (HRQoL) between 3 and 12 months in critically ill COVID-19 survivors. The secondary objective was to investigate factors associated with good functional outcome and HRQoL at 12 months. Methods
Plesiosaurs are an iconic group of Mesozoic marine reptiles with an evolutionary history spanning over 140 million years (Ma).1 Their skeletal remains have been discovered worldwide; however, accompanying fossilized soft tissues are exceptionally rare.2 Here, we report a virtually complete plesiosaur from the Lower Jurassic (∼183 Ma)3 Posidonia Shale of Germany that preserves skin traces from arou
Surgical systems are complex and susceptible to external system pressures. The SARS-CoV-2 pandemic and its impact on elective surgery illustrated this. The reassignment of resources to the acute care of patients with COVID-19 led to cancellations of elective services that varied according to surges of the pandemic. Overall, it was estimated that more than 28 million operations were cancelled or po
Purpose: A lack of standardization exists for functional tasks in return-to-activity (RTA) guidelines for adolescents with anterior cruciate ligament injury (ACLi). Identifying the variables that discern ACLi status among adolescents is a first step in the creation of such guidelines following surgical reconstruction. This study investigated the use of classification models to discern ACLi status
Objectives: We evaluated the protection afforded by SARS-CoV-2 infection-induced immunity against reinfection among working-age vaccinated individuals during a calendar period from June to December 2022 when Omicron BA.5 was the dominating subvariant in Scania County, Sweden. Methods: The study cohort (n = 71,592) mainly consisted of health care workers. We analyzed 4144 infected cases during the
Soil factors responsible for the inability of Visearía vulgaris to colonize or survive on calcareous soils in Scandinavia were studied using experiments with plant establishment from seeds and re-establishment of mature plants, in soils of naturally differing or artificially varied chemical properties. Limestone soil proved less suitable for re-establishment of mature plants, and establishment fro
OBJECTIVES: To investigate if the sport concussion assessment tool version 5 (SCAT5) could be suitable for application to Para athletes with a visual impairment, a spinal cord injury, or a limb deficiency.METHODS: A 16-member expert panel performed a Delphi technique protocol. The first round encompassed an open-ended questionnaire, with round 2 onwards being composed of a series of closed-ended s
Extracellular matrix remodeling mechanisms are understudied in cardiac development and congenital heart defects. We show that matrix-degrading metalloproteases ADAMTS1 and ADAMTS5, are extensively co-expressed during mouse cardiac development. The mouse mutants of each gene have mild cardiac anomalies, however, their combined genetic inactivation to elicit cooperative roles is precluded by tight g
A key strategy to support the vision of a circular economy is to promote the consumption of more sustainable products. Both the EU and its Member States have therefore adopted several policies to support this objective. We review these policies and discuss their potential to trigger changes in consumer behaviour. The discussion is focused on five ‘points of intervention’: (1) regulatory choice edi
Introduction: Until now, the mechanism underlying the impact of topping on hormone regulation in tobacco plants remains unclear, and most studies investigating the hormone signaling pathways in plants rely on genes or transcriptional pathways. Methods: This study examines the regulatory mechanisms of hormones in the roots and leaves of tobacco plants with and without topping at the protein level.
Community-acquired pneumonia is a serious public health problem, and more so in older patients, leading to high morbidity and mortality. However, this problem can be reduced by optimising in-hospital nursing care. Accordingly, this study describes a systematic process of designing and developing a tailored theory- and research-based implementation strategy that supports registered nurses (RNs) in
This report explores what the Nordic countries can do to promote the use of recyclable plastic components in electrical and electronic products, with particular focus on minimising their hazardous chemical component. The report provides an overview of the hazardous additives currently used in the plastic components of EEE, drawing on information available from legislation and supporting studies, r
