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Adduct formation between cationic reagents and targets on DNA are facilitated by the ability of DNA to attract cations to its surface. The electrostatic interactions likely provide the basis for the documented preference exhibited by cisplatin and related compounds for nuclear DNA over other cellular constituents. As an extension of a previous communication, we here present an investigation illust
Objective To investigate the basic pharmacodynamic properties of teicoplanin in vitro for Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium. Methods The following experiments were performed: (1) bacterial killing by teicoplanin at different concentrations; (2) bacterial killing by teicoplanin at 8 x MIC against the same strains with inocula of 5x10(3), 5x10(5) and 5x10(7)
Purpose Radiation therapy is frequently used in treating different types of tumors, although associated with serious side effects, such as fibrosis and complicated diarrhea. This study was designed to define the adhesive mechanisms behind radiotherapy-induced leukocyte recruitment in the colon. Methods All mice, except control animals, were radiated with a single dose of 20 Gy. Mice were pretreate
The dinuclear species [(trispicMeen)(ClFeOFeCl)-O-III-Cl-III(trispicMeen)]Cl(OH)(H2O)(7) (1) (trispicMeen = N,N,N'-tris-(2-pyridylmethyl)-N'-methylethane- 1,2-diamine) was synthesized. It crystallizes in the monoclinic space group C2/c with a = 33.87(2) Angstrom, b = 17.42(2) Angstrom, c = 23.41(5) Angstrom, beta = 132.88(5)degrees, V = 10 121(25) Angstrom(3), and Z = 8. It contains an almost line
Members of the transforming growth factor (TGF)-beta family play pivotal roles in the control of differentiation, proliferation and tolerance in peripheral T cells. Recently, they have been implicated in thymic selection, but their role is so far not well characterized. In the present study, we demonstrate that specific thymocyte populations are under the influence of either the TGF-beta and/or Ac
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical
Methods currently used for surface display on insect cells and budded baculovirus, all utilize the sequences from class I transmembrane proteins. This gives rise to some problems when handling unknown genes or cDNAs encoding full-length proteins. First, the stop codon from the cloned gene will be located upstream of the sequence for the transmembrane region. Second, the chance of getting the seque
A natural summer phytoplankton community from the Gullmar Fjord (Skagerrak, Swedish west coast) was diluted 10 times with filtered seawater in twelve 300-dm(3) polyethylene cylinders. Nutrients were added to produce two different molar ratios of nitrogen to silicon (N/Si 3.2/3.2 mu M=1 and 12.8/3.2 mu M=4). Three cylinders of each nutrient treatment were carefully mixed while the other three of ea
BACKGROUND: /st> Previous studies have indicated that autoantibodies may be detected years before the clinical onset of rheumatoid arthritis (RA). Cartilage biomarkers, such as cartilage oligomeric matrix protein (COMP), have not been studied previously in samples collected before the diagnosis of RA. METHODS: /st> Between 1991 and 1996, 30 447 subjects were included in the Malmö Diet Cancer Study
BACKGROUND: Severe meningitis may compromise cerebral perfusion through increases in intracranial pressure (ICP) and through hypovolemia caused by a general inflammation with systemic plasma leakage. From its antiaggregative/antiadhesive and permeability-reducing properties, prostacyclin (PGI2) is a potential adjuvant treatment in meningitis, but previously published data have been ambiguous. The
This work concerns an experimental study of pressure drop and heat transfer for turbulent flow inside a U-duct. Such duct geometries can be found in many engineering applications where cooling air extracts heat from hot internal walls of the duct, e.g., passage cooling inside gas turbine blades. Both friction factors and convective heat transfer coefficients were measured inside a U-duct for three
This study concerns whether the personality of drug addicts is related to their drug of choice. A group of 112 heavy drug addicts participated, each selected for either heroin (29 women, 52 men) or amphetamine (31 men) being their basic drug. Their personality was assessed by means of two percept-genetic techniques, the Spiral Aftereffect Technique (SAT) and the Defense Mechanism Technique modifie
Structural and electronic properties of a small anatase TiO2 nanocrystal sensitized by the ruthenium dye N3 (Ru(4,4‘-dicarboxy-2,2‘-bipyridine)2(NCS)2) have been investigated using density functional theory (DFT) with support from Hartree−Fock (HF) and time dependent DFT (TD-DFT) calculations. Significant structural adjustments of both the dye and the nanocrystal are predicted to be induced by the
