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BACKGROUND: The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not been investigated.METHODS: Three cohorts of glioma patients comprising 1500 patients were analyzed in our study along with their clinical data. H4, U-118 and
We present new data for the ∼3.0 Ga Maniitsoq Norite Belt of the Akia Terrane, West Greenland, with the aim of understanding its petrogenesis. The Maniitsoq Norite Belt is hosted in regional tonalite-trondhjemite-granodiorite (TTG) and dioritic orthogneisses, intruded by later sheets of TTG and granite pegmatites, and comprises two main rock types: plagioclase-rich “norites” and pyroxene-rich “mel
DNA is a highly charged polyelectrolyte and is prone to associative phase separation driven by the presence of multivalent cations, charged surfactants, proteins, polymers and colloids. The process of DNA phase separation induced by positively charged species is often called DNA condensation. Generally, it refers to either intramolecular DNA compaction (coil-globule transition) or intermolecular D
This article focuses on the rapidly growing Swedish market of app-based audio erotic fiction through an analysis of two significant apps and publishers: Blanche Stories and Ava Stories. We explore audio erotica apps as devices of both literature, pleasure and intimate sonic connectivity. First, we discuss the specific affordances of the born-audio format, its flexible and mobile forms of listening
INTRODUCTION: To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations. METHODS: A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD-PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florb
Health inequalities are a persistent and growing issue in different countries worldwide. Sweden, despite being one of the scandinavian countries with internationally recognized welfare system is no exception. The issue of health disparities and its increase among some groups, including those who are categorised as migrant have been acknowledged. Emergence of the COVID-19 pandemic, however, reveale
In the later Middle Ages and early modern period, many European hospitals developed into commercial retirement homes that allowed investors to pay for lifelong food and lodging. Their clients consisted mainly of elderly citizens who decided to spend their final years enjoying a pension, often living by themselves or occasionally with a spouse. Corrodies can best be understood as life annuities in
This paper is a comparison of water vapor resistance (Ret) measured using the Permetest skin model and Tore sweating thermal manikin, i.e. 2D versus 3D methods; and to study the relationship between them. Three materials and five air gap distances were used for the measurement between these two devices, the test conditions in the climatic chambers were set up according to the ISO standard of each
Purpose: To differentiate PCA segments and cortical branches by means of transcranial color-coded duplex sonography (TCCD) and to measure flow parameters at rest and during visual stimulation. Materials and Methods: 60 healthy subjects with a good acoustic temporal bone window were examined. The main stem of the PCA (P1, P2 and P3) and 4 main cortical branches-the anterior temporal artery (ATA), t
Objective: To assess the association between education and all-cause and cause-specific mortality among patients with osteoarthritis (OA) in comparison to an OA-free reference cohort.Methods: Using data from the Skåne healthcare register, we identified all residents aged ≥45 years in the region of Skåne, with doctor-diagnosed OA of peripheral joints between 1998 and 2013 (n=123,993). We created an
The local electronic structure of the metal-active site and the deexcitation pathways of metalloporphyrins are crucial for numerous applications but difficult to access by commonly employed techniques. Here, we applied near-edge X-ray absorption mass spectrometry and quantum-mechanical restricted active space calculations to investigate the electronic structure of the metal-active site of the isol
The benefit of surgery in high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) and mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) is uncertain. The present study aimed to investigate outcomes after tumour surgery in patients with high-grade (Ki-67 > 20%) GEP NEN or MiNEN stage I-III or stage IV. We analysed data from patients treated in the period 2007-2015 at eight Nord
We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data
Intimate partner violence against women (IPVAW) is a global public health issue often assumed to be associated with gender inequality. The so-called Nordic Paradox, the apparently contradictory co-existence of high levels of IPVAW and of gender equality in Nordic countries, has not been adequately explained. This study explores discussions about how this apparent paradox can be understood among 30
Aims To establish normative values of vibration perception thresholds (VPTs), using multi-frequency vibrometry at finger pulps and at metatarsal heads of the foot in healthy adults. We also aimed to investigate factors that could potentially affect VPTs such as age, sex, height, weight, foot- or handedness and skin temperature. Methods VPTs were examined in 924 healthy and randomly selected subjec
Background: Cognitive impairment (CI) is a key feature of late life depression (LLD), but the contribution of underlying neurodegenerative pathology remains unclear. Objective: To evaluate cognitive dysfunction in LLD relative to a sample of nondepressed (ND) older adults with matched levels of memory impairment and amyloid-β (Aβ) burden. Methods: Participants included 120 LLD and 240 ND older adu
Patterns of variation and the structuring of diversity in seed phenotype and allozymes were investigated in Sweden Gypsophila fastigiata, a perennial herb with a disjunct ‘Late Glacial relict’ distribution in eastern and northern Europe. The overall patterns of variation in allozymes and seed morphology are congruent and are significantly correlated with geographic distance. However, most of the c
What happens to dominant narratives and settled self-images of so-called peace nations when experiencing actual combat in out-of-area military missions? This question arises when studying the contemporary international engagement of small states that previously have mostly been engaged in peacekeeping with limited mandates and non-use of force restrictions. As today's international missions have a
A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was n
