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Acute myeloid leukemia (AML) with t(9;22)(q34;q11), also known as AML with BCR-ABL1, is a rare, provisional entity in the WHO 2016 classification and is considered a high-risk disease according to the European LeukemiaNet 2017 risk stratification. We here present a retrospective, population-based study of this disease entity from the Swedish Acute Leukemia Registry. By strict clinical inclusion cr
The minimal U(1)B−L extension of the Standard Model (B-L-SM) offers an explanation for neutrino mass generation via a seesaw mechanism; it also offers two new physics states, namely an extra Higgs boson and a new Z′ gauge boson. The emergence of a second Higgs particle as well as a new Z′ gauge boson, both linked to the breaking of a local U(1)B−L symmetry, makes the B-L-SM rather constrained by d
There are well-known expressions for natural frequencies and mode shapes of a Euler-Bernoulli beam which has classical boundary conditions, such as free, fixed, and pinned. There are also expressions for particular boundary conditions, such as attached springs and masses. Surprisingly, however, there is not a method to calculate the natural frequencies and mode shapes for a Euler–Bernoulli beam wh
AIM Enterococci cause 2-11% of all prosthetic joint infections (PJI) and are generally considered difficult to treat. However, study-results are not consistent. In this study we present a population-based case series of 55 cases with enterococcal PJI, investigating treatment and outcome, as well as describing the affected patient population regarding demography and co-morbidities. METHODS We ident
Epicardial adipose tissue has a paracrine effect, enhancing coronary artery atherosclerotic plaque development. This study evaluated epicardial fat volume (EFV), adipokines, coronary atherosclerosis, and adverse cardiovascular events in a cohort of asymptomatic patients with type 2 diabetes mellitus (T2DM). Epicardial fat volume was calculated using data from computed tomography coronary angiogram
Background: Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. Methods: A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive, a
The current research studied effects of different gender expressions (non-normative or normative)in two phases of recruitment: applicant attraction and applicant evaluation. Experiment 1 (N = 404) investigated how Equal Employment Opportunity (EEO) statements in an organisation description that emphasized gender as binary (women and men), gender as diverse (multi-gender), or gender as irrelevant (
Anomalous seasonal patterns of precipitation variability over South America (SA) associated with El Niño-Southern Oscillation (ENSO) and non-ENSO (residual) conditions were assessed during 1951–2016. Patterns were obtained from empirical orthogonal functions analysis of total and residual precipitation seasonal anomalies. In austral spring and summer, precipitation variability is dominated by a di
The ligand-binding domain of Fbl (the fibrinogen binding protein from Staphylococcus lugdunensis) shares 60% sequence identity with ClfA (clumping factor A) of Staphylococcus aureus. Recombinant Fbl corresponding to the minimum fibrinogen-binding region (subdomains N2N3) was compared with ClfA for binding to fibrinogen. Fbl and ClfA had very similar affinities for fibrinogen by surface plasmon res
Clinical reports on early immune dysregulation in acute pancreatitis (AP) are scarce. Herein we investigate the initial temporal development of selected biomarkers. Blood samples were taken at 0–24 and 25–48 h after onsets of AP were acquired. Mean values and temporal intermediate difference (delta-values) of IL-1β, IL-6, IL-8, IL-10, IL-12, IFN-γ and TNF-α were calculated. Differences between sev
The Brassica Information Portal (BIP) is a centralised repository for brassica phenotypic data. The site hosts trait data associated with brassica research and breeding experiments conducted on brassica crops, that are used as oilseeds, vegetables, livestock forage and fodder and for biofuels. A key feature is the explicit management of meta-data describing the provenance and relationships between
BACKGROUND: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymus on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.METHODS: The total p
Background: Early involvement of students in research processes is an important step in professional development and can increase the academic output of the university. Previous studies indicate low research involvement amongst undergraduate students, however limited research has been done in sub-Saharan Africa. This study aimed to describe the level of research involvement amongst undergraduate s
Wear mechanisms and failure modes were investigated for autoclave-cured, woven carbon fiber-reinforced polymer (CFRP) composite gears in a mesh with a surface-hardened, 42CrMo4 steel pinion. The reference gears (m = 1 mm, b = 2 mm, z = 20) were tested at torque levels ranging from 0.4 Nm to 0.8 Nm. The temperature was monitored with a thermographic camera, while the gear damage and wear volume wer
BACKGROUND: Oxygen free radicals (OFRs), platelet activating factor (PAF), cell adhesion molecules, and transmigration of polymorphonuclear leukocytes through the gut barrier are probably all essential in the development of gut barrier dysfunction following intestinal ischemia and reperfusion (I/R). Pretreatment and early treatment of I/R with the OFRs-scavenger (NAC), the PAF inhibitor lexipafant
Review of Engberg, Nils et al (eds) "Archaeology of Medieval Towns in the Baltic and North Sea Area" (Copenhagen 2009)
BACKGROUND AND DESIGN: The hypothesis that diets rich in total and saturated fat and poor in unsaturated fats increase the risk for cardiovascular disease is still vividly debated. The aim of this study was to examine whether total fat, saturated fat, or unsaturated fat intakes are independent risk factors for cardiovascular events in a large population-based cohort. METHODS: 28 098 middle-aged in
AIMS/HYPOTHESIS: PPARGC1A and PPARGC1B encode transcriptional coactivators that regulate numerous type 2 diabetes-related metabolic processes. Common genetic variation across PPARGC1A/B was characterised by genotyping tagging variants. We then tested associations of these variants with diabetes incidence or change in quantifiable metabolic traits directly or via interactions (with metformin treatm
Foot problems complicating diabetes are a source of major patient suffering and societal costs. Investing in evidence-based, internationally appropriate diabetic foot care guidance is likely among the most cost-effective forms of healthcare expenditure, provided it is goal-focused and properly implemented. The International Working Group on the Diabetic Foot (IWGDF) has been publishing and updatin
