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Background: The addition of anthracyclines to platinum-based chemotherapy may provide benefit in survival in ovarian cancer patients. We evaluated the effect on survival of adding epirubicin to standard carboplatin and paclitaxel. Patients and methods: We carried out a prospectively randomized phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) with t

Literature's ability to act - its performativity - is best shown in different performances, such as reading aloud, singing - in events. The different concepts and theories that form the foundation of an exploration of these performances in swedish culture in the period 1800 -2008 are presented, and also the organization of this exploration, eg a historical organization, structured according to dif

In adipocytes, PDE3B (phosphodiesterase 3B) is an important regulatory effector in signalling pathways controlled by insulin and cAMP-increasing hormones. Stimulation of 3T3-L1 adipocytes with insulin or the beta(3)-adrenergic receptor agonist CL316243 (termed CL) indicated that insulin preferentially phosphorylated/activated PDE3B associated with internal membranes (endoplasmic reticulum/Golgi),

Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail

This study investigated the role of P fimbriae in colonization of Escherichia coli, host response, and bacterial persistence in humans. Human volunteers were inoculated intravesically with the nonadherent ABU isolate E. coli 83972 and with P fimbriated transformants of the same strain. During the following 24 h all urine samples, and thereafter daily samples, were collected for urine culture, anal

We have analyzed the content of N-unsubstituted glucosamine in heparan sulfate from glypican-1 synthesized by endothelial cells during inhibition of (a) intracellular progression by brefeldin A, (b) heparan sulfate degradation by suramin, and/or (c) endogenous nitrite formation. Glypican-1 from brefeldin A-treated cells carried heparan sulfate chains that were extensively degraded by nitrous acid

Objectives: In this study, we investigated whether polymorphisms of the HIF-1 alpha gene may account for the patterns of HIF-1 alpha protein expression in non-small cell lung carcinomas (NSCLC) and the expression of HIF-1 alpha down-stream proteins. Methods: Specific HIF-1 alpha polymorphisms were assessed in a series of patients with NSCLC: (a) the C to T transition at nucleotide 1744 (position 2

A data set of adaptive optics images has been analyzed in order to study the effects of angular anisoplanatism and to characterize Mauna Kea nighttime turbulence. The data set consists of a selection of Galactic center images obtained with the adaptive optics instrument Hokupa'a and the near-infrared camera QUIRC on the Gemini-North 8 m telescope. Using the Strehl ratio and the FWHM as tracers for

Large eddy simulations (LES) are performed for single and multiphase jets in crossflow (JICF). The multiphase JICF are compared to the single-phase case for the same momentum and mass flow, ratios but with droplets of different sizes. Multiphase JICF have stronger counterrotating vortex pairs (CVPs) than a corresponding single-phase JICF. Moreover their trajectories are higher and their induced wa

We present Ar-40/Ar-39 data acquired by infra-red (CO2) laser step-heating of alunite crystals from the large Miocene Colquijirca district in central Peru. Combined with previously published data, our results show that a long (at least 1.3 My) and complex period of magmatic-hydrothermal activity associated with epithermal Au-(Ag) mineralization and base metal, Cordilleran ores took place at Colqui

Soon after the annexation of Crimea by the Russian Federation in March 2014, a peak moment in the events commonly referred to as the Ukraine crisis (Wilson A, Ukraine crisis. What it means to the West? Yale University Press, New Haven, 2014), media in Estonia and abroad started to speculate about whether Russia would stop at Crimea, or if Estonia, with its sizable Russian-speaking minority, would

Detta kandidatarbete har undersökt hur ett digitalt verktyg för att hjälpa autistiska individer med exekutiva funktioner i arbetet bör designas. Syftet med detta var att uppnå inkludering och öka produktiviteten på arbetsplatser men även öka livskvaliteten för autistiska individer enligt de globala målen i Agenda 2030 nummer 3 om god hälsa och välbefinnande respektive nummer 10 om minskad ojäm

This study aimed to examine the factors that influence the Swedish people’s willingness to adopt multiple eID services. Utilizing the Unified Theory of Acceptance and Use of Technology (UTAUT) as a foundational framework, we combined insights from previous research to design our survey, which received 300 responses divided into several age categories. This quantitative approach allowed for a broad

Voluntary Sustainability Standards (VSSs) build on market-based governance mechanisms to create fairer and more equitable terms of trade within smallholder-dominated agricultural value chains. Various frameworks and theoretical approaches have arisen to assess social impacts generated through VSSs; however, the findings are scattered and inconsistent. This thesis aims to contribute to a more nuanc