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To overcome the blur when visualizing of the interior of a turbid media by means light-based methods, a technique called Structured Laser Illumination Planar Imaging (SLIPI) is employed. The method is based on a 'light coding' strategy to distinguish between directly and multiply scattered light, allowing the intensity from the latter to be suppressed by post-processing data. In this paper, we exp

Proton-transfer dynamics plays a critical role in many biochemical processes, such as proton pumping across membranes and enzyme catalysis. The large majority of enzymes utilize acid-base catalysis and proton-transfer mechanisms, where the rates of proton transfer can be rate limiting for the overall reaction. However, measurement of proton-exchange kinetics for individual side-chain carboxyl grou

Science Journals — AAAS REVIEW SUMMARY ◥ OXYGEN SENSING Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity Emma U. Hammarlund*†, Emily Flashman, Sofie Mohlin, Francesco Licausi*† BACKGROUND:Animals and land plants are the most diverse complex multicellular life-forms on Earth, and their success intricately links a capacity for adhering cells to perform

https://www.tcr.lu.se/sites/tcr.lu.se/files/2020-11-16_hammarlund_et_al_2020.pdf - 2026-07-25

Recent studies indicate that defective activity of complement factor H (FH) is associated with several human diseases, suggesting that pure FH may be used for therapy. Here, we describe a simple method to isolate human FH, based on the specific interaction between FH and the hypervariable region (HVR) of certain Streptococcus pyogenes M proteins. Special interest was focused on the FH polymorphism

We present how dramatically the nonequilibrium nature of an oppsitely charged polyelectrolyte/surfactant mixture can affect the interfacial properties. We show for the first time that the cliff edge peak in the surface tension of the poly(diallydimethylammonium chloride)/sodium dodecyl surfate system is produced as a direct result of depletion of surface-active material from the bulk solution due

Recent advances in the digital detector technology have paved the way for modalities such as two-dimensional digital mammography (DM) and three-dimensional breast tomosynthesis (BT). In this work, experimental studies were conducted to investigate the influence of reducing the average glandular dose (AGD) on detection of simulated lesions in DM and to compare the diagnostic accuracy of BT and DM.

Helicobacter pylon is found commonly in the gut of the human beings and animals. This bacterium is found usually when patients suffer from upper GI infections. H. pylon has been found in the patients in antral biopsies in Mumbai, India. We have found H. pylon in antral biopsies and faeces in another Study we have done. The mode of transmission of H. pylon is yet not confirmed although two routes a

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46. Complete deficiency of FI, which is synthesized mainly in the liver is rare and leads to complement consumption resulting in recurrent severe infections, gl

Övergångsrättvisa (transitional justice) är en term som beskriver hur länder med hjälp av juridiska och icke-juridiska åtgärder hanterar storskaliga övergrepp mot mänskliga rättigheter. Övergångsrättvisa används bland annat för att hålla förövare ansvariga och bringa försoning. Konceptet övergångsrättvisa växte fram som ett gensvar på hur länder under 1980–1990-talet hanterade de storskaliga övergTransitional justice is a term and concept which describes how countries deal with large-scale human rights abuses through different judicial and non-judicial measures in order to achieve reconciliation and hold perpetrators accountable. Transitional justice as a concept was born out of practice as a response to how countries in the 1980–1990s dealt with large-scale abuses committed by the earlier

Det framgår av 7 § LAS att en uppsägning måste vara sakligt grundad. Vad som utgör saklig grund för uppsägning finns inte närmare angett i lag mer än att en uppsägning inte är sakligt grundad om det är skäligt att arbetsgivaren erbjuder arbetstagaren annat arbete hos sig, 7 § 2 st. LAS. Arbetsgivarens omplaceringsskyldighet gäller både vid uppsägningar på grund av personliga skäl och uppsägningar For a dismissal to be lawful it must fulfil the just cause requirement stipulated in Section 7 of LAS. The just cause requirement is not defined in neither LAS nor any other statute. Section 7 of LAS only explains that just cause will not be found if it is reasonable to demand that the employer provides the employee with different work tasks or transfers the employee to some other available positi

Purpose: The importance of body positivity is visible in its remarkable media presence. The movement entails challenges such as opportunities for brands. The purpose of this paper is to examine why companies adapt to the body positivity movement, what they are exactly doing regarding body positivity and how this is related to the brand’s reputation. Methodology: Literature and media review, Case

Context Adjuvant imatinib administered for 12 months after surgery has improved recurrence-free survival (RFS) of patients with operable gastrointestinal stromal tumor (GIST) compared with placebo. Objective To investigate the role of imatinib administration duration as adjuvant treatment of patients who have a high estimated risk for GIST recurrence after surgery. Design, Setting, and Patients Pa

The thermodynamics and kinetics of formation of host-guest complexes between a series of bolaform surfactants of type C(n)Me(6)(2+)2Br(-) (n = 8, 10, and 12) and alpha-cyclodextrin and beta-cyclodextrin were studied with the aid of isothermal titration calorimetry (ITC) at 298.15 and 308.20 K. The association constant, the enthalpy, and the entropy of formation were determined. The obtained thermo

The posttranslational modification of proteins has the potential to generate neoepitopes that may subsequently trigger immune responses. The carbamylation of lysine residues to form homocitrulline may be a key mechanism triggering inflammatory responses. We evaluated the role of carbamylation in triggering immune responses and report a new role for this process in the induction of arthritis. Immun

Organometal halide (OMH) perovskites have attracted lots of attention over the last several years due to their very promising performance as the materials for solar cells and light-emitting devices. Photophysical processes in these hybrid organic inorganic semiconductors are still heavily debated. To know precise absorption spectra is absolutely necessary for quantitative understanding of the fund

This study investigated the molecular basis of disease severity in acute pyelonephritis (APN), a common and potentially life-threatening bacterial infection. Two cohorts of infants with febrile urinary tract infection were included. Renal involvement was defined by DMSA scans and molecular disease determinants by gene expression analysis and proteomic screens, at diagnosis and after 6 mo. Innate i