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We present a method for the estimation of the distribution of the quasi-static hogging-bending moment for a floating body. Starting points of this study are temporal characteristics of the sea state. The approximation is deduced from the estimation of the joint distribution of crest amplitude and crest length. The quality of the model is investigated by comparing computed distributions with empiri
The article investigates the relationship between Sweden and the Ottoman Empire during the eighteenth century with a focus on the travelogue of Jacob Björnståhl.
The interaction of light with multiple red blood cells was systematically investigated by the finite-difference time-domain method (FDTD). The simulations showed that the lateral multiple scattering between red blood cells is very weak and that the polarization has an almost insignificant influence on the distribution of the scattered light. The numerical results of the FDTD method were compared w
We characterized the functional properties of a novel set of human anti-CD40 monoclonal antibodies originating from a human phage display library and identified an antibody that strongly activates cells via the CD40 receptor for potential use in HIV therapy. The anti-CD40 antibodies were converted from a single chain antibody fragment format (scFv) to an IgG format and produced in HEK293 cells, an
A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient
BACKGROUND. Hypoxia induces increased tumor growth by promoting angiogenic and glycolytic pathways. Tumors expressing hypoxia-inducible factor-la (HIF-1 alpha), an important transcriptional activator of oxygen-regulated genes, are resistant to chemotherapy and radiotherapy. The major challenge in prostate cancer therapy today is to gain a better understanding of the development of hormone-refracto
Protein is a soft material with inherently large structural disorder. Consequently, the bulk spectroscopies of photosynthetic pigment protein complexes provide averaged information where many details are lost. Here we report spectroscopy of single light-harvesting complexes where fluorescence excitation and detection polarizations are both independently rotated. Two samples of peripheral antenna (
Leflunomide is a low molecular weight immunosuppressive drug which inhibits the enzymes dehydroorotate dehydrogenase and protein tyrosine kinase, both of which are important components in the immune response. As the mechanisms of action of leflunomide and tacrolimus are different, we postulated an additive or synergistic effect of the two drugs and investigated the effects of leflunomide alone, or
The healthy vaginal ecosystem is maintained by the interaction of the vaginal epithelium and the microflora, where lactobacilli and occasionally bifidobacteria play an important role. Imbalances in the dominance of lactobacilli may lead to bacterial vaginosis or yeast vaginitis. Probiotics may be a means to secure a favourable microbial balance in the vagina and, as the normal vaginal flora ascend
The purpose of this study was to create and evaluate personalised virtual learning spaces (PVLSs) in a course that was previously delivered face-to-face only. The study addressed three related questions: (1) Can a PVLS successfully be introduced into a course where IT has not previously featured? (2) Can the PVLSs be used to enhance the assessment from an extended essay to a higher-level empirical
Impact work-rate of a weakly damped beam with elastic two-sided amplitude constraints subject to harmonic excitation is calculated. Impact work-rate is the rate of energy dissipation to the impacting surfaces. The beam is clamped at one end and constrained by unilateral contact sites near the other end. This system was an object of a vibro-impact experiment which was analyzed in our earlier paper
Bone marrow resident hematopoietic stem cells differentiate into all different types of lymphoid populations, there among mature naive B cells expressing IgM and IgD. During the maturation, the B cells are subjected to several steps of selection to ensure proper development of the antigen receptor. The mechanisms regulating the selection are to great extent unknown. In paper I of this thesis, we d
A leaner organization of labour, outsourcing and new forms of employment imply significant changes. Politicians and private employers alike emphasize that it is the individual's responsibility to be 'employable'. In his influential discussion of flexible capitalism, Richard Sennett traces the concept of flexibility back to fifteenth-century English. Then it was used with reference to patterns of m
A modern hearing aid should be aesthetically appealing as well as offer sufficient and adequate signal amplification. Due to the small physical size of these devices, acoustical feedback (howling) is a major problem. Apart from the annoyance and potential hearing damaging effects that howling implies, it also reduces the supplied maximum Real Ear Aided Gain (REAG). This paper proposes a novel method
Popular Abstract in Swedish Tyfoidfeber är en sjukdom som orsakas av bakterien Salmonella typhi. Denna bakterie, som sprids via vatten eller föda, orsakar buksmärtor, feber och illamående. Om infektionen inte behandlas med antibiotika, kan bakterien sprida sig till blodet och leda till döden. Årligen rapporteras 16 miljoner fall av salmonella i världen och av dessa får ungefär 600 000 dödlig utgånThis study investigates the interaction between dendritic cells (DC) and the Gram negative intracellular bacterium Salmonella typhimurium. Using in vitro and in vivo approaches, the capacity of DC to directly and indirectly present antigens from Salmonella-infected cells, cytokine production by infected DC, and activation of bacteria-specific T cells was analyzed. These studies revealed differenti
