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This paper discusses which freehand drawing skills a designer needs in the 21st century and why not more people are using sketching as a creative tool. Are design schools teaching the adequate skills needed today? In the past 5-10 years focus has shifted from product design to experience design and the skills needed to make high end drawings might not be needed to the same extent. 3D computational
Background: Previous work has demonstrated immunomodulatory, anti-tumor, anti-metastatic and anti-angiogenic effects of the small molecule quinoline-3-carboxamide tasquinimod in pre-clinical cancer models. To better understand the anti-tumor effects of tasquinimod in transplantable tumor models, we have evaluated the impact of the compound both on recruitment of myeloid cells to tumor tissue and o
Many observed giant planets lie on eccentric orbits. Such orbits could be the result of strong scatterings with other giant planets. The same dynamical instability that produces giant planet scatterings can also alter the orbits of terrestrial planets. For example, a habitable rocky planet in the system can be ejected or transported to an orbit outside the habitable zone. Therefore, there is a lin
This paper describes the involvement of end users in a project aimed to create a navigation aid for older persons who have memory decline, which affects navigation skills, and thus their independence. Interviews, focus groups with “stick man scenarios” and shorter usability tests seemed to work well. An extended test where the users themselves were expected to use the system independently was not
The Sound Environment Center at Lund University has for over ten years hosted interdisciplinary research on sound environment issues promoting an exchange of ideas between researchers through research projects, interdisciplinary symposiums and publications. The center aims at developing a holistic view to a field that is scientifically fragmented. Ranging from acoustics, noise abatement and sounds
γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology of γδ T cells it is crucial to define the constituting subpopulations. γδ T cells have previously been categorized into two subpopulations: CD8aa+ and CD8- cells. In this study we have defined and characterized a novel subset of human γδ T-cells e
The demographic development indicates an increased elderly population in Sweden in the future. One of the greatest challenges for a society with an ageing population is to provide high-quality health and social care. New information and communication technology and services can be used to further improve health care. To enable elderly persons to stay at home as long as possible, various kinds of t
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we h
Mechanical stimuli, such as wind, rain, and touch affect plant development, growth, pest resistance, and ultimately reproductive success. Using water spray to simulate rain, we demonstrate that jasmonic acid (JA) signaling plays a key role in early gene-expression changes, well before it leads to developmental changes in flowering and plant architecture. The JA-activated transcription factors MYC2
The notion of societal safety and security has recently been raised to deal with a composite landscape of diverse threats and vulnerabilities. The concept of resilience has gained currency in recent years in many contexts as an alternative to prevalent failure-oriented safety approaches. In order to be meaningful in a societal safety/security context, the resilience concept must be translated to a
The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these
Motivated by experimental findings on one-dimensional nano-materials, this contribution focusses on the elaboration of a fibre curvature based higher-order gradient contribution to the stored energy function in a finite deformation setting. The presented approach is based on the fundamental theoretical developments for fibre-reinforced composites presented by Spencer and Soldatos (2007), which tak
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. Mice with H. pylori infection develop severe gastritis and atrophic changes in their stomachs after 6 months. We followed H. pylori -infected animals for 13 months to find out whether dysplasia, carcinoma or lymphoma developed. Six-week-old C57BL/6 mice were infected
BACKGROUND: In animals, we have previously done successful lung transplantations using organs from non-heart-beating donors. We have also developed an ex-vivo system of assessing the function of such organs before transplantation. The next stage was to try the technique in human beings. Bearing in mind the sensitive ethical issues involved, our first aim was to find out what procedures would be ac
In this paper we describe a small pilot study designed to explore the possibility of spatial pseudo haptic effects induced by artificial audio feedback. Four basic audio designs were investigated: pan, continuous since tone, virtual harp and noise. For reference a visual pseudo haptic effect together with real haptic effects were also included. The results indicate noise and spatially distributed
Hur vi väljer att organisera våra familjer har genomgått en radikal förändring sedan mitten av 1900-talet. Kärnfamiljen är visserligen fortfarande den vanligaste familjeformen, men den har i allt större utsträckning kommit att kompletteras med en rad icke-traditionella familje-konstellationer, bl.a. samkönade familjer. Den här utvecklingen har naturligtvis också påverkat hur vi lever och praktisHow we choose to organize our families has changed significantly since the mid-20th century. It might be true that the nuclear family remains the most common family form. However, it has to an increasing extent been accompanied by a number of non-traditional families, including same-sex families. Naturally, this development has also affected the way we live and how we practice family life. While
Denna uppsats syftar till att diskutera den rasism som sägs blomstra i Europa, och mer specifikt i Sverige, idag. Detta görs genom att undersöka Sverigedemokraternas principprogram som antogs 2011. Den metod som används för att analysera programmet är en teoribaserad innehållsanalys. Teorin som används för analysen är den definition av rasism som görs av George M. Fredrickson och som presenteras iThis essay aims to discuss the racism that is said to flourish in Europe, and more specifically in Sweden, today. This is done by examining the Sweden Democrats' policy program adopted in 2011. The method used to analyze the document is a theory-based content analysis. The theory used for the analysis is the definiton of racism done by George M. Fredrickson as it is presented in his book "
Virtual communities, including communities dedicated to consumption practices, were named one of the rising modern trends. With the technological development, nowadays, people do not need actual locations to meet for being friends because multiple blooming social networks allow people to stay connected 24/7 no matter where they are in this world. This technological development has many positive ef
Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. We implement a 3D computational model of brain patterning to simulate this process. The mathematical model is set up by unifying two e
