Sökresultat

Most of the observed extrasolar planets are found on tight and often eccentric orbits. The high eccentricities are not easily explained by planet-formation models, which predict that planets should be on rather circular orbits. Here we explore whether fly-bys involving planetary systems with properties similar to those of the gas giants in the Solar system can produce planets with properties simil

Autoimmune (type 1) diabetes (AI-DM) is a multistage disorder. Children are born genetically predisposed to putative environmental exposures. These trigger an aggressive, selective and chronic autoimmune response against the pancreatic islet beta cells. This stage is marked by autoantibodies against insulin, glutamic acid decarboxylase (GAD65), IA-2 and the ZnT8 transporter. Progression to clinica

Popular Abstract in Swedish Under det senaste årtiondet har förekomsten av läkemedel i miljön rönt stor uppmärksamhet. Studier har visat att flera läkemedel hittats i sjöar och vattendrag och kan förorsaka negativa effekter hos vattenlevande organismer. Den i särklass största vägen via vilken läkemedel når miljön är avloppsreningsverk. Efter att vi ätit ett läkemedel kommer kroppen också att utsönThis thesis addresses the application of hollow fiber liquid phase microextraction as a simple, efficient and environmentally friendly tool to study the fate of four common anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) during wastewater treatment. Initial experiments verified that this technique is applicable on aqueous as well as suspensions of solid samples, thus great

We studied the A-band photodissociation of bromoiodomethane, CH2BrI, in acetonitrile solution at room temperature by femtosecond pump-probe spectroscopy, Initiated by the 266 nm light, this reaction leads to the CH2Br-I isomer, most likely produced via in-cage recombination of the CH,Br and I photofragments. The isomer is formed vibrationally excited with a time constant of similar to7.5 ps and th

There is currently an imbalance with regards to the way that risks are treated in construction projects. Risks associated with structural failures as well as construction safety risks are often in focus while building performance risks (e.g. related to moisture or energy performance) receive less attention. These types of risks often disproportionately affect the end users/owners and can in many c

About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. The aim of this thesis was to evaluate new potential prognostic biomarkers in breast cancer, and with special focu

BACKGROUND: Toll-like receptors enable the host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharide, viral RNA, CpG-containing DNA and flagellin. Toll-like receptors have also been shown to play a pivotal role in both innate and adaptive immune responses. The role of Toll-like receptors as a primary part of our microbe defense system has been

Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli

This chapter explores how nursing home managers grapple with local manifestations of the wicked problems that plague elderly care. It shows the tension between managers' lofty ideals of high-quality, individualized care and their continuous struggle to handle very basic troubles that ultimately appear to be grounded in a lack of resources, such as high personnel turnover and staff complaints about

Aim: To describe the detailed health-related quality of life (HRQoL) in survivors from the TTM-trial and to investigate potential differences related to sex and age. Methods: This is a cross-sectional study originating from a large prospective international, multicentre trial, including 442 respondents who answered the Short Form-36 item Questionnaire Health Survey version 2® (SF-36v2®) at a struc

Human exposures to metals and metalloids such as arsenic frequently occur as mixtures, and hence it is important to consider interactions among these elements in terms of both mechanisms of action and for risk assessment purposes. Interactions among these elements may produce additive, synergistic/potentiative, or antagonistic effects that may be manifested as direct cellular toxicity (necrosis or

Data on longitudinal lung function change in the elderly are scarce. Uncertainty remains about whether to use absolute or relative change and how it relates to subject demographics.We studied absolute and relative forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) change in a population-based geriatric sample using a repeated measurements model adjusted for age, sex, smoking ha

The diversity among Swedish university students is steadily increasing. The students have different backgrounds, experiences, interests, learning styles and abilities. Also, there are more students with disabilities at Swedish universities, especially invisible disabilities. Teachers need to adapt their teaching and curricula, and can no longer wait to do this until they spot a student with divers

CONTEXT: Pharmacodynamic studies have shown that persistently high platelet reactivity is common in patients with diabetes in spite of clopidogrel treatment. Clinical trials have not convincingly demonstrated that clopidogrel benefits patients with diabetes as much patients without diabetes.OBJECTIVES: To estimate the clinical effectiveness associated with clopidogrel treatment after myocardial in

Malignant melanoma (MM) is a frequent form of cancer with increasing incidence. 6-10% of patients with MM report a family history of MM, and in most populations 2% of unselected cases of MM carry a CDKN2A mutation. tvWe present a family with 24 cases of MM in nine persons from several generations, caused by a previously undescribed germ-line intronic mutation in CDKN2A. Through genetic counselling